Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement

Bullón, Pedro; Román-Malo, Lourdes; Marín-Aguilar, Fabiola; Álvarez-Suarez, José M.; Giampieri, Francesca; Battino, Maurizio; Cordero, Mario D.

doi:10.1016/j.phrs.2014.10.007

Cited by 57 publications

(54 citation statements)

References 18 publications

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“…According to a recent report [8], dietary supplementation with CoQ 10 resulted in a significant decrease in LPS-induced ROS production and a significant improvement of mitochondrial functions in vitro study. There are numerous reports that the application of CoQ 10 to laboratory animals, which were treated with toxic substances such as LPS, could help to maintain a normal level of antioxidant enzymes and antioxidant status in the liver [21035].…”

Section: Discussionmentioning

confidence: 99%

“…In general, however, it is clear that dietary supplementation with CoQ 10 attenuates hepatic oxidative injury via the modulation of antioxidant enzymes and their antioxidant capacities under severe oxidative stress circumstance [836], although the detailed antioxidant mechanisms of CoQ 10 were not fully elucidated. In agreement with this hypothesis, our study also demonstrated that supplementation with CoQ 10 in rats challenged with LPS maintained the same level of SOD, GPX and lipid peroxidation in comparison with the control rats.…”

Section: Discussionmentioning

confidence: 99%

“…The free radical scavenging properties of CoQ 10 have been known to serve as a crucial antioxidant activity to prevent lipid and membrane oxidation against pro-oxidative damage in tissues [78]. Hence, dietary supplementation with CoQ 10 has an effective tool of scavenging reactive oxygen species (ROS) due to its ability to quench singlet oxygen and peroxy radicals [9].…”

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confidence: 99%

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Effects of coenzyme Q₁₀on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

et al. 2017

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The study was performed to see the effects of coenzyme Q10 (CoQ10) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ10/kg BW with LPS (LCQI) and 300 mg of CoQ10/kg BW with LPS (LCQII). The LPS and LCQI groups showed a significant (P<0.05) increase in the relative spleen weight compared with the CON group without affecting body and liver weights. The blood alanine aminotransferase (ALT) level in the LPS group was significantly (P<0.05) greater than that in the CON group, while supplementation with 100 or 300 mg CoQ10 to rats injected with LPS normalized the ALT level in the CON group. In antioxidant systems, the LPS group showed a significantly (P<0.05) higher mRNA and activity of superoxide dismutase (SOD) than the CON group. The supplementation with CoQ10 to the LPS-treated group normalized the level of SOD, which was comparable to the level of the CON group. Both the mRNA expression and activity of glutathione peroxidase in the LCQI and LCQII groups were higher (P<0.05) than that of the LPS group. However, administration of LPS or CoQ10 unaffected the level of catalase and total antioxidant power. The level of lipid peroxidation in the LCQII group was lower (P<0.05) than that in the LPS group. In conclusion, CoQ10 exerted its favorable effect against liver damage by modulation of antioxidant enzymes in LPS treated rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of coenzyme Q₁₀on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

et al. 2017

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“…In skeletal muscle, melatonin (a powerful antioxidant) might counteract inducible mtNOS-triggered dysfunction of the ETC, as recently demonstrated in septic mice [105]. Other mitochondria-targeted lipophilic antioxidants like coenzyme Q 10 improved mitochondrial biogenesis in LPS-treated mice by activating PGC-1 α and Tfam [106]. One such approach covalently links biomolecules to lipophilic triphenylphosphonium cation (TPP+).…”

Section: Mitochondrial-targeted Therapies To Promote Mitohormesis mentioning

confidence: 99%

Skeletal Muscle and Lymphocyte Mitochondrial Dysfunctions in Septic Shock Trigger ICU-Acquired Weakness and Sepsis-Induced Immunoparalysis

Maestraggi

Lebas

Clère-Jehl

et al. 2017

BioMed Research International

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Fundamental events driving the pathological processes of septic shock-induced multiorgan failure (MOF) at the cellular and subcellular levels remain debated. Emerging data implicate mitochondrial dysfunction as a critical factor in the pathogenesis of sepsis-associated MOF. If macrocirculatory and microcirculatory dysfunctions undoubtedly participate in organ dysfunction at the early stage of septic shock, an intrinsic bioenergetic failure, sometimes called “cytopathic hypoxia,” perpetuates cellular dysfunction. Short-term failure of vital organs immediately threatens patient survival but long-term recovery is also severely hindered by persistent dysfunction of organs traditionally described as nonvital, such as skeletal muscle and peripheral blood mononuclear cells (PBMCs). In this review, we will stress how and why a persistent mitochondrial dysfunction in skeletal muscles and PBMC could impair survival in patients who overcome the first acute phase of their septic episode. First, muscle wasting protracts weaning from mechanical ventilation, increases the risk of mechanical ventilator-associated pneumonia, and creates a state of ICU-acquired muscle weakness, compelling the patient to bed. Second, failure of the immune system (“immunoparalysis”) translates into its inability to clear infectious foci and predisposes the patient to recurrent nosocomial infections. We will finally emphasize how mitochondrial-targeted therapies could represent a realistic strategy to promote long-term recovery after sepsis.

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“…Besides multiple selenoproteins, coenzyme Q10 is also one of the important antioxidants in the body [12]. The functions of these two classes are interrelated; the selenoenzyme TrxR1 being needed for the cell to reduce coenzyme Q10 (ubiquinone) to its active form ubiquinol [13, 14].…”

Section: Introductionmentioning

confidence: 99%

Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

et al. 2017

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BackgroundSelenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with increasing age. Supplementation with selenium and coenzyme Q10 in elderly have shown reduced cardiovascular mortality and reduced levels of markers of inflammation. However, microRNA analyses could give important information on the mechanisms behind the clinical effects of supplementation.MethodsOut of the 443 healthy elderly participants that were given supplementation with 200 μg Se/day as organic selenium yeast tablets, and 200 mg/day of coenzyme Q10 capsules, or placebo for 4 years, 25 participants from each group were randomized and evaluated regarding levels of microRNA. Isolation of RNA from plasma samples and quantitative PCR analysis were performed. Volcano- and principal component analyses (PCA)–plots were used to illustrate the differences in microRNA expression between the intervention, and the placebo groups. Serum selenium concentrations were measured before intervention.FindingsOn average 145 different microRNAs out of 172 were detected per sample. In the PCA plots two clusters could be identified indicating significant difference in microRNA expression between the two groups. The pre-treatment expression of the microRNAs did not differ between active treatment and the placebo groups. When comparing the post-treatment microRNAs in the active and the placebo groups, 70 microRNAs exhibited significant differences in expression, also after adjustment for multiple measurements. For the 20 microRNAs with the greatest difference in expression the difference was up to more than 4 fold and with a P-value that were less than 4.4e-8.ConclusionsSignificant differences were found in expression of more than 100 different microRNAs with up to 4 fold differences as a result of the intervention of selenium and coenzyme Q10 combined. The changes in microRNA could be a part of mechanisms underlying the clinical effects earlier reported that reduced cardiovascular mortality, gave better cardiac function, and showed less signs of inflammation and oxdative stress following the intervention. However, more research is needed to understand biological mechanisms of the protective effects of selenium and Q10 supplementation.

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Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement

Cited by 57 publications

References 18 publications

Effects of coenzyme Q₁₀on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

Effects of coenzyme Q₁₀on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

Skeletal Muscle and Lymphocyte Mitochondrial Dysfunctions in Septic Shock Trigger ICU-Acquired Weakness and Sepsis-Induced Immunoparalysis

Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

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Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement

Cited by 57 publications

References 18 publications

Effects of coenzyme Q10on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

Effects of coenzyme Q10on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

Skeletal Muscle and Lymphocyte Mitochondrial Dysfunctions in Septic Shock Trigger ICU-Acquired Weakness and Sepsis-Induced Immunoparalysis

Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

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Effects of coenzyme Q₁₀on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

Effects of coenzyme Q₁₀on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity