Lipopolysaccharide increases degradation of central monoamines: An in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice

Heesch, Floor van; Prins, Jolanda; Konsman, Jan Pieter; Korte-Bouws, G.A.H.; Westphal, Koen G.C.; Rybka, Joanna; Olivier, Berend; Kraneveld, Aletta D.; Korte, S. Mechiel

doi:10.1016/j.ejphar.2014.01.014

Cited by 37 publications

(29 citation statements)

References 51 publications

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“…Together, these findings warrant further investigation of a role for p38 MAPK in a more physiologic context and in relation to other regulatory signals. That latent regulation by a p38 MAPK pathway may explain the findings of van Heesch et al (2014), who found that low dose (133 mg/kg) of lipopolysaccharide (LPS), an inflammatory agent, could rapidly induce changes in DA turnover suggestive of elevated DAT activity. Possibly related to these findings, Wu et al (2014) found that injection of the proinflammatory cytokine TNF-a increased DAT levels.…”

Section: A Regulation Of Dopamine Transporter By P38 Mitogen-activatmentioning

confidence: 96%

Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters

Bermingham

Blakely

2016

Pharmacol Rev

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Section: A Regulation Of Dopamine Transporter By P38 Mitogen-activatmentioning

confidence: 96%

Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters

Bermingham

Blakely

2016

Pharmacol Rev

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“…For example, single injections of septic doses of LPS (5 mg/ kg) cause progressive neurodegeneration of the nigrostriatal DArgic system (Qin et al, 2007;Reinert et al, 2014). It should be noted that acute systemic administration of low-dose LPS (~100 μg/kg) has been reported to either decrease tissue DA content or increase extracellular DA metabolites in the NAcc (van Heesch et al, 2014;Yeh et al, 2015). However, these studies assessed DA and 'anhedonic' behavior (sucrose preference or responding for brain stimulation) at 2-4 h post LPS (van Heesch et al, 2014;van Heesch et al, 2013;Yeh et al, 2015), a time point that may be confounded due to the febrile effects of LPS and related sickness behaviors (Dinarello, 2004;Frenois et al, 2007;O'Connor et al, 2009b).…”

Section: Biochemical and Behavioral Studies In Laboratory Animalsmentioning

confidence: 99%

“…It should be noted that acute systemic administration of low-dose LPS (~100 μg/kg) has been reported to either decrease tissue DA content or increase extracellular DA metabolites in the NAcc (van Heesch et al, 2014;Yeh et al, 2015). However, these studies assessed DA and 'anhedonic' behavior (sucrose preference or responding for brain stimulation) at 2-4 h post LPS (van Heesch et al, 2014;van Heesch et al, 2013;Yeh et al, 2015), a time point that may be confounded due to the febrile effects of LPS and related sickness behaviors (Dinarello, 2004;Frenois et al, 2007;O'Connor et al, 2009b). These early effects of LPS may also reflect, for instance, acute activation of neuroendocrine peptides and hormones (minutes to hours), which can have stimulatory effects on turnover or release of brain catecholamines (Barrot et al, 2000;Lavicky and Dunn, 1993;Matsuzaki et al, 1989;Mekaouche et al, 1996), and which may occur ahead of the more chronic mechanisms by which inflammation is thought to contribute to decreased DA availability (see the section 'Mechanisms of inflammation effects on dopamine synthesis and release' below for detailed discussion).…”

Section: Biochemical and Behavioral Studies In Laboratory Animalsmentioning

confidence: 99%

“…These early effects of LPS may also reflect, for instance, acute activation of neuroendocrine peptides and hormones (minutes to hours), which can have stimulatory effects on turnover or release of brain catecholamines (Barrot et al, 2000;Lavicky and Dunn, 1993;Matsuzaki et al, 1989;Mekaouche et al, 1996), and which may occur ahead of the more chronic mechanisms by which inflammation is thought to contribute to decreased DA availability (see the section 'Mechanisms of inflammation effects on dopamine synthesis and release' below for detailed discussion). Nevertheless, both the short-and long-term effects of LPS on brain DA can be blocked by inhibition or genetic deletion of inflammatory cytokines such as TNF (Qin et al, 2007;Tian et al, 2006;van Heesch et al, 2014). Even localized inflammation in the hind paw following carrageenan administration has been shown to decrease DA release in the insula (Coffeen et al, 2010).…”

Section: Biochemical and Behavioral Studies In Laboratory Animalsmentioning

confidence: 99%

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Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

Felger

Treadway

2016

Neuropsychopharmacol

318

237

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Motivational and motor deficits are common in patients with depression and other psychiatric disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in motivation and motor function are associated with alterations in corticostriatal neurocircuitry, which may reflect abnormalities in mesolimbic and mesostriatal dopamine (DA). One pathophysiologic pathway that may drive changes in DAergic corticostriatal circuitry is inflammation. Biomarkers of inflammation such as inflammatory cytokines and acute-phase proteins are reliably elevated in a significant proportion of psychiatric patients. A variety of inflammatory stimuli have been found to preferentially target basal ganglia function to lead to impaired motivation and motor activity. Findings have included inflammation-associated reductions in ventral striatal neural responses to reward anticipation, decreased DA and DA metabolites in cerebrospinal fluid, and decreased availability, and release of striatal DA, all of which correlated with symptoms of reduced motivation and/or motor retardation. Importantly, inflammation-associated symptoms are often difficult to treat, and evidence suggests that inflammation may decrease DA synthesis and availability, thus circumventing the efficacy of standard pharmacotherapies. This review will highlight the impact of administration of inflammatory stimuli on the brain in relation to motivation and motor function. Recent data demonstrating similar relationships between increased inflammation and altered DAergic corticostriatal circuitry and behavior in patients with major depressive disorder will also be presented. Finally, we will discuss the mechanisms by which inflammation affects DA neurotransmission and relevance to novel therapeutic strategies to treat reduced motivation and motor symptoms in patients with high inflammation.

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“…Usually, microdialysis samples are acidified with acetic acid, perchloric acid or formic acid after collection. Subsequently, the samples are analyzed immediately or frozen at −20 • C or −80 • C prior to analysis [14,[29][30][31][32][33][34][35][36]. Few researchers analyze the samples directly as such [28,[37][38][39] or do not mention any precaution to ensure stability [16,[40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%