Lipoproteiks, Aging, and Coronary Artery Disease

The serum lipoprotein transport system in health, metabolic disorders, atherosclerosis and coronary heart disease

“…The application of the statistical method known as Fisher's Linear Discriminant analysis allows assessment of the relative importance of the two lipoprotein measurements for the segregation of myocardial infarcts from matched controls. Our most recent evaluation 45 has yielded the result that the S f°1 2-400 lipoproteins are 1.6 times as important as the S f°0 -12 lipoproteins, milligram for milligram, in the separation of myocardial infarcts from matched controls. A useful approach in referring to the concentration of lipoproteins with respect to Figure 7 Comparison of S f°0 -12 substrate alone, after incubation with pre-heparin bottom fraction, and after incubation with post-heparin "active" fraction.…”

In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

“…Statins are also known to inhibit directly ABCB1, and for the various statins, the IC 50 values match congruently the inhibition of ATP hydrolysis (Bogman et al 2001 ; Wang et al 2001 ; Goard et al 2010 ; Sieczkowski et al 2010 ; Werner et al 2013 ). Consequently, statins enhance the intracellular accumulation of ABCB1 substrates like doxorubicin, which augments cytotoxicity in neuroblastoma and rhabdomyosarcoma cells and may provide the classical argument for usage in an anti-cancer therapy (Tamplin et al 1954 ; Werner et al 2004 , 2013 ; Demierre et al 2005 ; Goard et al 2010 ; Sieczkowski et al 2010 ; Tanaka et al 2010 ).…”