Lipoprotein(a): A Promising Marker for Residual Cardiovascular Risk Assessment

Cai, Anping; Liu, Liwen; Zhang, Ying; Mo, Yujing; Mai, Weiyi; Zhou, Yingling

doi:10.1155/2013/563717

Cited by 44 publications

(55 citation statements)

References 109 publications

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“…Prognostic value of a significant increase in LP(a) in serum, as an important predictor of CV events, was confirmed in the studies that included patients with dyslipidaemia, hypertension, diabetes, the history of CV disease and non-alcoholic hepatic steatosis (NAHS) [38,72,73]. In parallel, the role of LP(a) as a genetic risk factor for CV disease was explained.…”

Section: Dyslipidaemia and Non-alcoholic Fatty Liver Diseasementioning

confidence: 83%

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Kuzmіnova

Gribenyuk

Osovska

et al. 2016

Arterial Hypertension

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The combination of hypertension, obesity and non-alcoholic fatty liver disease occurs in medical practice very often. A number of studies have shown that non-alcoholic fatty liver disease increases the risk of cardiovascular disease independently of other predictors and manifestations of the metabolic syndrome. Current issues of research and identification of common pathogenic relationships of obesity, hypertension, and liver steatosis are investigated in the article. According to the analysed literature, it is indicated that insulin resistance and compensatory hyperinsulinaemia are considered as one of the key factors in the development of this comorbidity. The processes of chronic inflammation are increasing with the growth of adipose tissue volume. Some researchers believe that non-specific systemic inflammation combines arterial hypertension, increased body weight (especially abdominal obesity), steatosis, dyslipidaemia, atherogenesis and arteriosclerosis into a single syndrome. The role of non-alcoholic fatty liver disease in the growth of the thickness of the intima-media complex was studied. It is known that adipose tissue functions as an endocrine organ, expresses genes encoding bioactive substances, and secretes certain cytokines. A strong link between dysfunction of adipose tissue in patients with non-alcoholic fatty liver disease and in such conditions as metabolic syndrome and cardiovascular disease was demonstrated. The dysfunction of the endothelium is also advisable to consider as the connecting link between liver disease, obesity and hypertension. Despite some understanding of common pathogenic mechanisms for the development of non-alcoholic fatty liver disease and hypertension, this comorbid pathology remains the subject of much debate and a variety of studies. key words: arterial hypertension, obesity, non-alcoholic fatty liver disease, insulin resistance, dyslipidaemia, non-specific systemic inflammation, endothelial dysfunction, atherogenesis.

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Section: Dyslipidaemia and Non-alcoholic Fatty Liver Diseasementioning

confidence: 83%

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Kuzmіnova

Gribenyuk

Osovska

et al. 2016

Arterial Hypertension

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“…Studies have demonstrated that Lp(a) elevation is associated with impairment of endothelial function and increased risk of cardiovascular events [36,37]. In the long-term follow-up of patients undergoing percutaneous coronary intervention, Kardys et al [38] observed that Lp(a) was associated with a higher 1-year risk of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Early Atherosclerosis Markers in Patients with Inflammatory Bowel Disease

et al. 2016

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BackgroundThe aim of this study was to investigate relationships between early atherosclerosis and inflammatory bowel disease (IBD) using laboratory, functional, and morphological markers of atherosclerosis.Material/MethodsIn the present prospective single-center study, 96 patients with IBD (58 patients with ulcerative colitis and 36 patients with Crohn’s disease) and 65 healthy control subjects were included. The demographic data of each patient and control subject were recorded. The patients with IBD and healthy controls were compared in terms of the carotid intima-media thickness (CIMT), the values of flow-mediated dilatation (FMD) and nitroglycerine-mediated dilatation (NMD), and the levels of von Willebrand factor antigen (VWF-Ag), D-dimer, and lipoprotein (a).ResultsThere were no significant differences between the IBD patients and controls in terms of age, sex, BMI, systolic and diastolic BPs, serum levels of total cholesterol, low-density lipoprotein, or triglycerides. IBD patients had significantly higher levels of VWF-Ag (156.6±58.9 vs. 104.2±43.3, P<0.001) and D-dimer (337.2±710.8 vs. 175.9±110.9, P<0.001) as compared to the controls. No significant differences were determined between the 2 groups in terms of FMD and NMD values. Although statistically not significant, the CIMT values were higher in the IBD patients than in the controls (0.517±0.141 mm vs. 0.467±0.099 mm, P=0.073). In the correlation analysis, the CIMT was found to be correlated negatively with FMD and positively with high sensitive C-reactive protein, VWF-Ag, and D-dimer.ConclusionsThese findings suggest that VWF-Ag and D-dimer can be beneficial early atherosclerosis markers in IBD patients.

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“…Biomarkers associated positively with prevalent and incident cardiovascular disease including coronary heart disease and stroke include C-reactive protein (hs-CRP) 1–5 , lipoprotein-associated phospholipase A2 (LpPLA2) 2,6,7 , cardiac troponin T (cTnT) 8 , N-terminal pro-brain natriuretic peptide (NT-proBNP) 9 , lipoprotein(a) (Lp(a)) 10–14 , cystatin C 15–18 , and urine albumin to creatinine ratio 9,19,20 . Additionally, atherosclerosis as assessed using imaging techniques such as carotid intima media thickness (cIMT), carotid artery plaque, and coronary artery calcium measured on a computed tomography (CT) scan, have also been shown to be associated positively with CVD and to improve coronary heart disease risk prediction 21–26 .…”

Section: Introductionmentioning

confidence: 99%

Biomarkers and degree of atherosclerosis are independently associated with incident atherosclerotic cardiovascular disease in a primary prevention cohort: The ARIC study

Agarwala

Virani²,

Couper

et al. 2016

Atherosclerosis

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Background and aims Biomarkers and atherosclerosis imaging have been studied individually for association with incident cardiovascular disease (CVD); however, limited data exist on whether the biomarkers are associated with events with a similar magnitude in the presence of atherosclerosis. In this study, we assessed whether the presence of atherosclerosis as measured by carotid intima media thickness (cIMT) affects the association between biomarkers known to be associated with coronary heart disease (CHD) and incident cardiovascular disease (CVD) in a primary prevention cohort. Methods 8,127 participants from the ARIC study (4th visit, 1996–1998) were stratified as having minimal, mild, or substantial atherosclerosis by cIMT. Levels of C-reactive protein, lipoprotein-associated phospholipase A2, cardiac troponin T, N-terminal pro-brain natriuretic peptide, lipoprotein(a), cystatin C, and urine albumin to creatinine ratio were measured in each participant. Hazard ratios were used to determine the relationship between the biomarkers and incident CHD, stroke, and CVD in each category of atherosclerosis. Results While each of the biomarkers was significantly associated with risk of events overall, we found no significant differences noted in the strength of association of biomarkers with CHD, stroke, and CVD when analyzed by degree of atherosclerosis. Conclusions These findings suggest that the level of atherosclerosis does not significantly influence the association between biomarkers and CVD.

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Lipoprotein(a): A Promising Marker for Residual Cardiovascular Risk Assessment

Cited by 44 publications

References 109 publications

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Evaluation of Early Atherosclerosis Markers in Patients with Inflammatory Bowel Disease

Biomarkers and degree of atherosclerosis are independently associated with incident atherosclerotic cardiovascular disease in a primary prevention cohort: The ARIC study

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