Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age

Sandkamp, M.; Funke, Harald; Schulte, Helmut; Köhler, S. Eleonore; Assmann, Gerd

doi:10.1093/clinchem/36.1.20

Cited by 383 publications

(84 citation statements)

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“…Multivariate regression analysis confirmed the negative correlation between the concentrations of Lp(a) and TG (r = -0.31; P < 0.001) as well as the positive correlation with HDL-cholesterol ( Table 2). These relationships were not observed in 1237 controls from the Prospective Cardiovascular Munster (PROCAM) Study [19,20].…”

Section: Resultsmentioning

confidence: 91%

Effect of hypertriglyceridaemia on lipoprotein (a) serum concentrations

Walek

Eckardstein

Schulte

et al. 1995

Eur J Clin Investigation

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Numerous studies have shown lipoprotein (a) [Lp(a)] serum levels above 0.3 gL-1 to be a genetically determined and independent risk factor for atherosclerotic vascular disease. In this study of sera from 1009 patients attending our lipid clinics, multivariate regression analysis revealed an inverse correlation between the serum concentrations of triglycerides (TG) and Lp(a) (r = -0.31; P < 0.001) as determined by electroimmunodiffusion. This was not observed in 1237 controls from a random population. Detailed analysis of the frequency distribution of Lp(a) levels at different degrees of hypertriglyceridaemia (HTG) revealed a decreasing dosage effect of HTG on Lp(a) serum levels. In 60% of patients with TG > 9.12 mmol L-1, this effect led to undetectable serum Lp(a) levels. Dilution of hypertriglyceridaemic samples with normotriglyceridaemic sera containing high levels of Lp(a) revealed that analytical interference in part accounts for the decreasing effect of TG-rich lipoproteins on Lp(a). Re-evaluation of 45 hypertriglyceridaemic samples by enzyme immunoassay and immunoblotting revealed the presence of small amounts of Lp(a) in several samples which were considered to be free of Lp(a) upon electroimmunodiffusion. We conclude that TG-rich lipoproteins interfere with the quantification of Lp(a), at least by electroimmunodiffusion. However, HTG may also decrease Lp(a) plasma concentrations in vivo, possibly by increased clearance of TG-rich Lp(a).

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Section: Resultsmentioning

confidence: 91%

Effect of hypertriglyceridaemia on lipoprotein (a) serum concentrations

Walek

Eckardstein

Schulte

et al. 1995

Eur J Clin Investigation

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“…A number of prospective studies have demonstrated an association between Lp(a) level and the risk of coronary artery disease [10,12,36,37], but not all studies have found such a relationship [38,39]. Elevated Lp(a) levels may distinguish those patients with familial hypercholesterolaemia and clinically overt coronary heart disease from those without the disease [36,40], although it may also be regarded as a part of the clinical syndrome of familial hypercholesterolaemia [41].…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein(a) levels in relation to diabetic complications in patients with non‐insuIin‐dependent diabetes

Heesen¹,

Wolffenbuttel²,

Leurs³

et al. 1993

Eur J Clin Investigation

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Abstract.The relationship between serum levels of lipoprotein(a) (Lp(a)) and the presence of chronic diabetic complications was studied in 194 patients with non-insulin-dependent diabetes mellitus (NIDDM; 75 males, 119 females; age 6 6 k 1 1 years; duration of diabetes, 11 (range 1-35) years). They were taking various treatments (diet alone, oral hypoglycaemic agents and/or insulin). Metabolic status and prevalence of diabetic complications were assessed by detailed history, physical examination, laboratory analysis and ECG. Average metabolic control was moderate (HbAI, 8.2f 1.7%). Median serum Lp(a) level was 183 U 1-' (range 8-2600 U I-'), which was significantly higher than in control subjects of comparable age (median 101; range 8-1747 U I-'; P

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“…However, we did ®nd higher levels of Lp(a) in our ANCA-positive patients. Elevated levels of Lp(a) (³300 mg L )1 ) are an independent risk factor for cardiovascular disease, especially in patients with premature atherosclerosis [24]. Higher levels of Lp(a) have been reported in patients with SLE and anti-phospholipid syndrome as well [25,26].…”

Section: Discussionmentioning

confidence: 99%