2013
DOI: 10.1111/jth.12056
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Lipoprotein(a), polymorphisms in the LPA gene, and incident venous thromboembolism among 21 483 women

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Cited by 36 publications
(19 citation statements)
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“…12,16,17 Lp(a) has been implicated in both atherogenesis and thrombosis. [18][19][20][21][22][23][24][25] Our study also demonstrated that the plasma Lp(a) levels were significantly elevated according to the quartiles of the Gensini scores in CAD patients. The alleles of 2 SNPs in the LPA gene, rs10455872 and rs3798220, have been shown to be associated with high plasma levels of Lp(a) and CAD in Europeans.…”
Section: Discussionsupporting
confidence: 71%
“…12,16,17 Lp(a) has been implicated in both atherogenesis and thrombosis. [18][19][20][21][22][23][24][25] Our study also demonstrated that the plasma Lp(a) levels were significantly elevated according to the quartiles of the Gensini scores in CAD patients. The alleles of 2 SNPs in the LPA gene, rs10455872 and rs3798220, have been shown to be associated with high plasma levels of Lp(a) and CAD in Europeans.…”
Section: Discussionsupporting
confidence: 71%
“…When applied to assessment of associations between genetically elevated Lp(a) levels and different forms of venous thrombosis, however, the results have been uniformly negative (129)(130)(131). These findings quite definitely rule out a role for elevated Lp(a) in the etiology of venous thrombosis.…”
Section: Arterial Thrombosismentioning
confidence: 93%
“…More recently, however, genetic approaches have provided strong evidence against a role for Lp(a) in venous thrombosis (129)(130)(131). Because certain SNPs, such as rs3798220 (Ile4399→Met) and rs10455872 (intronic A/G polymorphism), are strongly associated with plasma Lp(a) concentrations, they can serve as surrogate markers for Lp(a) concentrations while also facilitating measurement in very large prospective cohorts where measurement of Lp(a) concentrations would be either cost-prohibitive or otherwise impossible.…”
Section: Venous Thrombosis and Thromboembolismmentioning
confidence: 99%
“…Although there have been discrepant results reported in the past, 3 recent, large, studies each also assessing LPA genotype at SNPs strongly associated with Lp(a) levels have concluded that no relationship between elevated Lp(a) and venous thromboembolism exists. [47][48][49] One study argued that this is evidence against a role for Lp(a) in the thrombotic complications of atherosclerosis. 47 There are, however, notable differences between the thrombi in arterial and venous compartments, with arterial thrombi being more platelet-rich, fibrin-poor, and initiated by the thrombogenic contents of the atherosclerotic core.…”
Section: Lipoprotein(a)mentioning
confidence: 99%