Lipoprotein(a), type 2 diabetes and vascular risk in coronary patients

Abstract

Lp(a) in diabetic coronary patients is low and not associated with the incidence of vascular events. Although measurement of Lp(a) provides useful information in nondiabetic coronary patients, it is of little value in coronary patients with T2DM.

Plasma Lipoprotein(a) Indicates Risk for 4 Distinct Forms of Vascular Disease

“…Our study did not have the power to dissect this relationship fully, because some groups (AAA patients and controls) had low numbers of diabetics. This relationship, however, is consistent with a recent study of 587 CAD patients, which showed that type 2 diabetes patients within the cohort had significantly lower concentrations of Lp(a) than those without diabetes (42 ). The mechanism by which diabetes decreases Lp(a) is unknown, but merits further investigation.…”

Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men

“…Venous blood samples were collected after an overnight fast of 12 h before angiography was performed, and laboratory measurements were performed from fresh serum samples, as described previously [31]. The serum levels of triglycerides, total cholesterol, and high density lipoprotein (HDL) cholesterol were determined by using enzymatic hydrolysis and precipitation techniques (Triglycerides GPO-PAP, CHOD/PAP, QuantolipLDL, QuantolipHDL; Roche, Basel, Switzerland) on a Hitachi-Analyzer 717 or 911.…”

Effects of Nateglinide and Glibenclamide on Prothrombotic Factors in Naieve Type 2 Diabetic Patients Treated with Metformin: A 1-Year, Double-Blind, Randomized Clinical Trial

“…Other factors are involved in the thrombofilic status associated to diabetes, like increased plasma level of XII, XI, and VIII coagulation factors (9), platelet hypersensitivity to collagen (10), an increased circulating pool of tissue factor (11), and sometimes also an increase in Lipoprotein (a) plasma level (12).…”