Lipoprotein levels in newborns and adolescents

Gozlan, Orly; Gross, Didi; Gruener, Nachman

doi:10.1016/0009-9120(94)90033-7

Cited by 14 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, all biochemical factors examined were higher in girls than in boys, but this difference was significant only for total cholesterol and HDL‐C. Although a gender difference is suggested for LDL‐C and non‐HDL‐C components, we did not find previous studies that suggested a gender difference for combined HDL‐C and non‐HDL‐C components in cord blood lipids 14 . We found it for the HDL‐C component alone.…”

Section: Discussioncontrasting

confidence: 97%

See 1 more Smart Citation

Cord blood lipid profile and associated factors: baseline data of a birth cohort study

Kelishadi

Badiee

Adeli

2007

Paediatric Perinatal Epid

View full text Add to dashboard Cite

Summary The cord blood lipid profile may be associated with lifelong changes in the metabolic functions of the individual. The aim of the present study was for the first time in Iran to assess the cord blood lipid profile of neonates, as well as some of its environmental influencing factors. The subjects were 442 (218 boys and 224 girls) normal vaginal delivery newborns. Overall, 14.4% of neonates were preterm and the rest were full‐term. In total, 9.2% (n = 35) of the full‐term newborns were small‐for‐gestational‐age (SGA), of which 16 had a ponderal index (PI) below the 10th percentile (SGA I) and 19 had a PI above the 10th percentile (SGA II), 5.5% (n = 21) were large‐for‐gestational‐age (LGA), and the remainder were appropriate‐for‐gestational‐age (AGA).Before becoming pregnant, 6.9% of mothers were underweight, 49.3% had normal body mass index (BMI), 39.4% were overweight and 4.4% were obese. Total and high‐density lipoprotein cholesterol (HDL‐C) in girls were significantly higher than in boys (80.3 ± 33.3 and 31.1 ± 9.9 vs. 73.3 ± 23.1 and 28.8 ± 8.7 mg/dL, respectively, P < 0.05). The mean apolipoprotein A (apoA) of neonates with underweight mothers was significantly lower, and the mean apoB level of those with overweight mothers was significantly higher than other neonates. The mean low‐density lipoprotein cholesterol (LDL‐C), HDL‐C and apoA of the LGA newborns were significantly lower, and their apoB was significantly higher compared with AGA and SGA neonates. The SGA I neonates had significantly lower total cholesterol, LDL‐C, HDL‐C and apoA, as well as higher triglycerides, lipoprotein a and apoB than the SGA II group. The mean cord blood triglycerides of full‐term neonates was significantly higher than preterm neonates (69.4 ± 11.9 vs. 61.4 ± 12.7 mg/dL, respectively, P = 0.04). A preconception maternal BMI of ≥25 kg/m2 correlated significantly with the cord triglycerides (OR = 1.3, [95% CI 1.07, 1.5]) and with apoB (OR = 1.4, [95% CI 1.1, 1.5]). The BMI <18 of mothers before pregnancy correlated with low HDL‐C (OR = 1.3, [95% CI 1.04, 1.7]). Birthweight correlated with high cord triglyceride level (SGA: OR = 1.4, [95% CI 1.1, 1.7]; LGA: OR = 1.6, [95% CI 1.3, 1.7] compared with AGA). These associations remained significant even after adjusting for the preconception BMI of mothers. Our findings reflect the possible interaction of environmental factors and fetal growth and the in utero lipid metabolism. Long‐term longitudinal studies in different ethnicities would help to elucidate the relationship.

show abstract

Section: Discussioncontrasting

confidence: 97%

“…Although a gender difference is suggested for LDL-C and non-HDL-C components, we did not find previous studies that suggested a gender difference for combined HDL-C and non-HDL-C components in cord blood lipids. 14 We found it for the HDL-C component alone. The LDL/HDL ratios were similar (1.1) in both genders.…”

Section: Discussionmentioning

confidence: 72%

Cord blood lipid profile and associated factors: baseline data of a birth cohort study

Kelishadi

Badiee

Adeli

2007

Paediatric Perinatal Epid

View full text Add to dashboard Cite

show abstract

“…[3][4][5][6] Therefore, efforts are being made for screening of hyperlipidemia in the neonatal period as cholesterol levels in the subsequent periods are likely to be influenced by other factors: constitutional and environmental. Factors which influence in-utero atherogenesis include fetal gender, gestational age, birth weight, perinatal stress, and maternal hypertension and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Factors which influence in-utero atherogenesis include fetal gender, gestational age, birth weight, perinatal stress, and maternal hypertension and diabetes. [3][4][5][6] Cord sera have been demonstrated to contain all well characterized adult lipoproteins and apolipoproteins. Hence determination of cord blood lipids becomes a useful investigation in detection of high risk babies who may have altered levels of lipids and lipoproteins compared to that found in healthy neonates.…”

Section: Introductionmentioning

confidence: 99%