Lipoprotein lipase: structure, function, regulation, and role in disease

Mead, James R.; Irvine, Scott Alexander; Ramji, Dipak Purshottam

doi:10.1007/s00109-002-0384-9

Cited by 758 publications

(592 citation statements)

References 190 publications

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“…Insulin is known to exert a direct regulatory effect on HL and LPL. 107,108 Interestingly, only a few studies 6,52,56 adjusted for the effect of insulin. Mudali et al 6 showed that adjustments for insulin, BMI and other covariates did not significantly influence associations of SHBG with HDL-C and triglycerides.…”

Section: Lipid Profilementioning

confidence: 99%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest on the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between testosterone and cardiovascular health in postmenopausal women. Published studies relating testosterone and sex hormone-binding globulin (SHBG) to CVD and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high testosterone and low SHBG levels, is associated with an adverse CVD risk factor profile in postmenopausal women. However, evidence for an association with cardiovascular events is lacking and it is uncertain whether the observed associations with endogenous testosterone have clinical implications regarding the use of postmenopausal testosterone therapy. Large-scale, longitudinal studies relating testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the long-term efficacy and safety of testosterone therapy in postmenopausal women.

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Section: Lipid Profilementioning

confidence: 99%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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“…8,13,16,17 LPL plays a crucial role in lipoprotein metabolism and transport by catalyzing the rate-limiting step in the hydrolysis of TG component of circulating chylomicrons (CM) and very low-density lipoproteins (VLDL). 18 Thus, it implies that LPL controls the distribution of free fatty acids (FFA) within the body. Accordingly, changes in the tissue specific expression pattern of LPL are expected to affect the initiation and development of obesity.…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study

Huang

Zhan

et al. 2006

Int J Obes

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Objective: To investigate the impact of lipoprotein lipase (LPL) gene S447X polymorphism on the relation between central obesity and lipid levels. Design: A total of 961 adult twin pairs were included from the program of Chinese Twin Registry, between 2001 and 2002. Central obesity was defined as waist circumference X90 cm for male and X80 cm for female. Two statistical methods were performed to test the modification effect of S447X polymorphism of LPL gene on the relation between central obesity and lipid levels: one was Generalized Estimating Equation (GEE) models for all twin pairs and the other was co-twin matched case-control analysis in 82 central obesity discordant monozygotic twin pairs. Results: In GEE models for all twins, central obesity was significantly associated with serum lipids except for high-density lipoprotein (HDL), while X447 allele had favorable effects on the levels of triglyceride (TG), HDL and TG to HDL ratio (TG/HDL). The interactions of S447X polymorphism and central obesity were statistically significant for TG/HDL and HDL. In central obesity discordant monozygotic twin pairs, central obesity was significantly related with 26.2% increase of TG and 27.2% increase of TG/HDL in S/S447 genotype, while in 447X allele carrier, central obesity was significantly related with 13.7% increase of HDL. Conclusion: These results suggest that LPL gene S447X polymorphism modifies the relation between central obesity and serum lipids, which also stresses the importance of reducing waist circumference to improve serum lipids for people with central obesity, especially those with S/S447 genotype.

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“…However, Oscar et al (2006) has observed t h a t LPL activity is directly associated with VLDL. On the other hand, abnormalities in LPL function have been found t o be associated with obesity a n d increase in triglyceride concentrations (Mead et al, 2002). There is significant correlation between LPL activity in abdominal fat and fat pad weight in birds, it means that the abdominal fat pad depot in birds of the high VLDL line takes up lipoprotein-borne fatty acids at 6-8 times the rate of that in the low VLDL line (Griffin et al, 1987).…”

Section: Resultsmentioning

confidence: 99%