Lipoprotein profile determined by a detailed lipidogram in normal and malnourished patients

Leglise, D; Ménez, J. F.; Youinou, Pierre; Garré, M; Floch, H.H.; Bardou, L.

doi:10.1007/bf02909325

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…It is important to note that the results of our study differed from the lipoprotein profile of children with protein-calorie malnutrition (PCM). Several studies in PCM children from India, Venezuela, and Nigeria have shown a rather significant rise in triglycerides and a significant decline in cholesterol (23)(24)(25)(26)(27)(28) .…”

Section: Discussionmentioning

confidence: 99%

Serum Lipoprotein Profile in Children With Celiac Disease

Rosenthal,

Hoffman,

Aviram

et al. 1990

J. pediatr. gastroenterol. nutr.

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SummaryJejunal mucosa is responsible for the absorption of triglycerides and the production of lipoproteins [chylomicrons, very‐low‐density lipoprotein (VLDL), high‐density lipoprotein (HDL)] and apolipoproteins (B‐48, A‐I, A‐II, A‐IV, C‐II). Mucosal damage is known to cause fat malabsorption and probably also affects the serum lipid profile. To determine lipoprotein production in states of enterocyte dysfunction, we compared the serum lipid profiles in a group of 12 children with untreated celiac disease (flat jejunal mucosa) with the profiles in a control group of 10 children suffering from other intestinal diseases. Statistically significant differences were found in the following parameters (celiac versus control): plasma levels of triglycerides (70 versus 119 mg/dl), cholesterol content in LDL (107 versus 67.7 mg/dl), protein content in VLDL (6 versus 10 mg/dl), and level of apoprotein A‐I (112 versus 140 mg/dl). No significant differences were found between the two groups in the serum levels of total cholesterol, the cholesterol content in VLDL and HDL, the protein content in LDL and HDL, and the level of apoprotein B. Following institution of a gluten‐free diet, the lipoprotein profile reverted to normal. These data suggest that the changes in the serum lipoprotein profile in celiac disease are secondary to alterations in enterocyte function and not only a reflection of fat malabsorption.

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Section: Discussionmentioning

confidence: 99%