2020
DOI: 10.1016/j.addr.2020.07.019
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Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting

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Cited by 211 publications
(135 citation statements)
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References 431 publications
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“…So, the "cholesterol hypothesis" was born because of these studies, which hypothesized that LDL-C is responsible for the progression of atherosclerosis and that reducing LDL-C would lower the risk of myocardial infarction and other cardiovascular events. (Soppert et al, 2020). Therefore, the present study showed that diet 3 had recorded low LDL-C and high HDL-C, and low records of CRI-I, CRI-II, and AC.…”
Section: Discussionmentioning
confidence: 41%
See 1 more Smart Citation
“…So, the "cholesterol hypothesis" was born because of these studies, which hypothesized that LDL-C is responsible for the progression of atherosclerosis and that reducing LDL-C would lower the risk of myocardial infarction and other cardiovascular events. (Soppert et al, 2020). Therefore, the present study showed that diet 3 had recorded low LDL-C and high HDL-C, and low records of CRI-I, CRI-II, and AC.…”
Section: Discussionmentioning
confidence: 41%
“…So, to reduce the risk e cient and effective therapies are highly needed (Soppert et al, 2020;Weber & Noels, 2011). Natural and dietary bioactive compounds (Mozaffarian & Ludwig, 2010), and a healthy lifestyle (Berciano & Ordovás, 2014;Shari -Rad et al, 2020) are believed to prevent coronary artery disease (Shari -Rad et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Dyslipidemia refers to a spectrum of metabolic disorders characterized by either an excess or a deficiency of lipoprotein particles, resulting in elevated plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) or triglyceride (TG) and/or depressed high-density lipoprotein cholesterol (HDL-C). Blood levels of different lipoproteins are strongly associated with the risk of cardiovascular diseases [ 34 ]. Thus, the management of blood lipid levels has an enormous significance for the control of these diseases.…”
Section: Antidislipidemic Effectmentioning
confidence: 99%
“…1,2 Lipid dysregulation has therefore been linked to diseases such as cancer, cardiovascular disease, diabetes, and other metabolic disorders as well as toxic exposures and environmental perturbations. [3][4][5] Thus, recent studies have focused on understanding lipid functions and biological mechanisms for their use as biomarkers or to create novel disease treatments and thoroughly evaluate system perturbations. However, lipidomic studies are often challenged by the extensive concentration range lipids exhibit in biological samples as well as the separation and data annotation challenges associated with the structural similarity and isomeric nature of lipids.…”
Section: Introductionmentioning
confidence: 99%