Lipoproteins, Insulin and Glycaemic Control in Diabetes

Abstract

Elevated plasma concentrations of triglyceride (TG) and cholesterol (chol) are well recognized in diabetes (Saudek and Eder 1979), and are of potential importance in the pathogenesis of atherosclerosis. We measured lipids and lipoproteins in insulin and non-insulin treated diabetic patients, and in non-diabetic controls. Results are corrected for differences in body weight, and also related to glycaemic control and insulin levels. Methods We studied 104 adult diabetic outpatients and 89 age and sex matched controls. Plasma lipids and lipoproteins were measured after a 12 hour fast (Lipid Research Clinics Program, 1974). In the diabetics fasting plasma glucose, HbA 1 C (column chromatography) and insulin (McCarroll 1971) were also measured. Differences in lipoproteins were adjusted for the effects of body weight by an analysis of co-variance. Correlation coefficients were calculated for associations between lipoproteins and plasma glucose, HbA,C and insulin. Sig-Table 1 Plasma lipid and lipoprotein levels in diabetics and controls

Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid‐Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus

“…Alloxan is known for its selective pancreatic islet β cell cytotoxicity and has been extensively used to induce diabetes mellitus in animals [67]. Generalized increase in the level of blood glucose during diabetes has been consistently reported both in animal models [68] and humans especially those suffering from insulin dependent diabetes mellitus [69]. In this study, increase in blood glucose level was observed on induction of diabetes mellitus in the rats models, which has been reduced in a dose dependent manner with the highest percentage reduction at 300 mg/kg (Tables 1 and 2).…”