Liposomal Controlled Release Ag-Activated DNAzyme Cycle Amplification on a 2D Pyrene COF-Based Photocathode for α-Synuclein Immunosensing

Gao, Yao; Zhang, Jinling; Zhang, Xuechen; Li, Jiawen; Zhang, Rui; Song, Wenbo

doi:10.1021/acs.analchem.1c01789

Cited by 27 publications

(17 citation statements)

References 45 publications

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“…A second strategy involves the electrode modification with Covalent Organic Nanosheets (also known as CONs [72,73]), produced by delamination of COFs usually by liquid phase exfoliation (LPE) and subsequent drop casting of CONs colloids [74][75][76]. Finally, the sensor's design can be based on simple electrodes [58,61] of dual systems, highlighting the sandwich-type electrodes [77,78].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical (Bio)Sensors Based on Covalent Organic Frameworks (COFs)

Martínez‐Periñán

Martínez-Fernández

Segura

et al. 2022

Sensors

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Covalent organic frameworks (COFs) are defined as crystalline organic polymers with programmable topological architectures using properly predesigned building blocks precursors. Since the development of the first COF in 2005, many works are emerging using this kind of material for different applications, such as the development of electrochemical sensors and biosensors. COF shows superb characteristics, such as tuneable pore size and structure, permanent porosity, high surface area, thermal stability, and low density. Apart from these special properties, COF’s electrochemical behaviour can be modulated using electroactive building blocks. Furthermore, the great variety of functional groups that can be inserted in their structures makes them interesting materials to be conjugated with biological recognition elements, such as antibodies, enzymes, DNA probe, aptamer, etc. Moreover, the possibility of linking them with other special nanomaterials opens a wide range of possibilities to develop new electrochemical sensors and biosensors.

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Section: Introductionmentioning

confidence: 99%

Electrochemical (Bio)Sensors Based on Covalent Organic Frameworks (COFs)

Martínez‐Periñán

Martínez-Fernández

Segura

et al. 2022

Sensors

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“…14 Moreover, PECs have been considered as promising portable sensing devices with commercial uses. Although aptamers have been increasingly used as specific recognition elements in PCE sensors, 15 few works have reported the combination of the recognition aptamer and PEC techniques for the detection of PAEs.…”

Section: Introductionmentioning

confidence: 99%

Competitive Displacement Triggering DBP Photoelectrochemical Aptasensor via Cetyltrimethylammonium Bromide Bridging Aptamer and Perovskite

Shen

Guan

et al. 2022

Anal. Chem.

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Here, a label-free perovskite-based photoelectrochemical (PEC) aptasensor was rationally designed for the displacement assay of dibutyl phthalate (DBP), a well-known endocrine disruptor, with the aid of cetyltrimethylammonium bromide (CTAB). In this method, CTAB significantly enhanced the PEC response and humidity resistance of the CH3NH3PbI3 perovskite by forming a protecting layer and passivating the X- and A-sites vacancies of CH3NH3PbI3. In addition, CTAB facilitated the immobilization of an aptamer through van der Waals and hydrophobicity forces, as well as the electrostatic interactions between the phosphate group of the aptamer and the cationic group of CTAB. When exposed to DBP in the affinity solution, the DBP aptamer was released from the electrode because the affinity between DBP and its aptamer competes with the interaction of the aptamer and CTAB. The displacement of the aptamer from the perovskite surface relieves the block effect and thus enhances the photoelectric signal of perovskite. By virtue of the good photoelectrochemical characters of CH3NH3PbI3 and the specific recognition ability of aptamer, the linear range of the PEC sensor was 1.0 × 10–13 to 1.0 × 10–8 M and the detection and quantification limits were down to 2.5 × 10–14 and 8.2 × 10–14 M (S/N = 3), respectively. This work offers a novel strategy for designing aptasensors for the detection of various targets and exhibits the marvelous potential of organic–inorganic perovskite in the field of PEC analysis.

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“…Hence, the split-type immunoassay was realized. As for the split-type mode, separating the sandwich-type immunoassay from EC sensing could effectively avoid complex steric hindrance and immune interference at a single EC sensing interface. ,, Thus, a more efficient EC response could be obtained. Besides, applying the Tri-Ag NPs TSC–GSH/GSSG NRMs to construct the sensing interface could acquire excellent EC response under a low oxidation potential.…”

Section: Introductionmentioning

confidence: 99%

Designing Triangular Silver Nanoplates with GSH/GSSG Surface Mixed States as Novel Nanoparticle-based Redox Mediators for Electrochemical Biosensing

et al. 2022

ACS Appl. Mater. Interfaces

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Herein, a dual signal-quenched electrochemical (EC) biosensing strategy utilizing surface-engineered trisodium citrate (TSC)− glutathione (GSH)/oxidized glutathione (GSSG)-capped triangular silver nanoplates (Tri-Ag NPs TSC−GSH/GSSG ) as a novel nanoparticle-based redox mediator was explored for biomarker determination. In contrast with conventional redox mediators, Tri-Ag NPs TSC−GSH/GSSG provided more admirable EC performance along with a lower oxidation potential (∼0.14 V). Taking advantage of the split-type mode, the immune response in a 96well microplate was independent from EC detection, which could effectively eliminate the biological interference and thereby greatly enhance the sensitivity. As for the surface engineering process of Tri-Ag NPs, it was composed of partial GSH replacement and the formation of the GSH/ GSSG surface mixed state. Primarily, the signal response of Ag NPs TSC−GSH decreased due to the hindrance of GSH on electron transfer. Moreover, varying proportions of GSH/GSSG could further impede the oxidation process of Tri-Ag NPs TSC−GSH/GSSG and eventually realize efficient dual signal quenching of this system. Notably

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Liposomal Controlled Release Ag-Activated DNAzyme Cycle Amplification on a 2D Pyrene COF-Based Photocathode for α-Synuclein Immunosensing

Cited by 27 publications

References 45 publications

Electrochemical (Bio)Sensors Based on Covalent Organic Frameworks (COFs)

Electrochemical (Bio)Sensors Based on Covalent Organic Frameworks (COFs)

Competitive Displacement Triggering DBP Photoelectrochemical Aptasensor via Cetyltrimethylammonium Bromide Bridging Aptamer and Perovskite

Designing Triangular Silver Nanoplates with GSH/GSSG Surface Mixed States as Novel Nanoparticle-based Redox Mediators for Electrochemical Biosensing

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