Liposomal Formulation of Turmerone-Rich Hexane Fractions from<i>Curcuma longa</i>Enhances Their Antileishmanial Activity

Amaral, Ana Cláudia F.; Gomes, Luciana A.; Silva, Jefferson Rocha de Andrade; Ferreira, José Luiz P.; Ramos, Aline de Souza; Rosa, Maria do Socorro S.; Vermelho, Alane Beatriz; Rodrigues, Igor A.

doi:10.1155/2014/694934

Cited by 14 publications

(5 citation statements)

References 42 publications

(29 reference statements)

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“…A number of these chemical components have established pharmacological potentials. Typically, 2,4-bis (1,1-dimethylethyl)-phenol found in both the subfractions is reported to possess anti-inflammatory (Amaral et al 2014;Chandrasekar et al 2015;Kumar, Bhatnagar & Srivastava 2011;Yogeswari et al 2012), neuronal and antioxidant (Yang et al 2016) effects. The 2,4-di-tert-butylphenol plays a significant role as an antioxidant and marine metabolite (NLM 2020).…”

Section: Discussionmentioning

confidence: 99%

Mitigation of free radicals and carbohydrate-linked enzymes by extracts and partitioned fractions of Elephantorrhiza elephantina (Burch.) Skeels root

Moloi

Balogun

Ashafa

2021

Journal of Medicinal Plants for Economic Development

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Background: Elephantorrhiza elephantina (Burch.) Skeels is a medicinal plant used in folkloric medicine for the management of several metabolic and infectious diseases.Aim: This aim of this research study was to investigate the antioxidant and antidiabetic effects of extracts and partitioned fractions in order to validate its folkloric use.Setting: The plant material purchased from herb sellers in Qwaqwa township, authenticated at Department of Plant Science Qwaqwa herbarium, was evaluated in the same unit of the University of the Free State.Methods: The antioxidative and antidiabetic activities of extracts and fractions were assessed with 1,1-diphenyl-2-picrylhydrazyl, 2,2-azino-bis(3-ethylbenzothiazoline-6)-sulphonic acid, hydroxyl radicals, metal chelating agents, and α-amylase, as well as α-glucosidase inhibitions based on standard methods. The subfractions with considerable yields from the partitioned n-hexane fraction of the crude extract were subjected to gas chromatography-mass spectrometry analysis or profiling for possible compound identification.Results: The aqueous extract showed the most effective 1,1-diphenyl-2-picrylhydrazyl, hydroxyl radical and metal chelating activities judging by half-maximal inhibitory concentrations (IC50: 0.573, 0.059 and 1.937 mg/mL, respectively), whilst the ethanol extract revealed maximum activity (0.017 mg/mL) against 2,2-azino-bis(3-ethylbenzothiazoline-6)-sulphonic acid. However, the ethanol extract displayed the most potent alpha-amylase (0.346 mg/mL) inhibition, whilst the aqueous extract (0.363 mg/mL) was best against alpha-glucosidase. The modes of enzymes inhibition revealed that the aqueous extract displayed near-competitive inhibition against alpha-amylase and uncompetitive inhibition against alpha-glucosidase. Additionally, good antioxidative and antihyperglycaemic effects were established by the n-hexane fraction when compared with standards (gallic acid and acarbose). The GC-MS chromatogram of subfractions (4 and 9) from the n-hexane fraction afforded compounds, such as 2,4-bis (1, 1-dimethylethyl)-phenol, 9-octadecenoic acid (Z)-, methyl ester, dodecanoic acid and 1-methylethyl ester already established in the literature with potential pharmacological activities (antioxidant, anti-inflammatory, etc.).Conclusion: The research study provides evidence on the folkloric use and insights on the prospect of the plant as natural antioxidative and antidiabetic agents.

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Section: Discussionmentioning

confidence: 99%

Mitigation of free radicals and carbohydrate-linked enzymes by extracts and partitioned fractions of Elephantorrhiza elephantina (Burch.) Skeels root

Moloi

Balogun

Ashafa

2021

Journal of Medicinal Plants for Economic Development

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“…The GC MS patterns revealed peaks that represented (5-octadecene, (E-phenol,2,4-bis (1,1 dimethylethyl; 1-Nonadecene; 1-Eicosanol; 1-Docosene and podocarp-7-en-3-one, 13‫-ב‬methyl-13-vinyl-). The antibacterial, antifungal and anti-inflammatory activities of phenol, 2,4bis (1,1-dimethylethyl)-have previously been reported 30,31 . 1-nonadecene extracted from the Streptomyces sp.…”

Section: Chemical Characterization Of the Ethyl Acetate Extractmentioning

confidence: 96%

“…To study the effect of temperature on the production of antimicrobial agents, isolate Streptomyces sp. MK388207 (M12) was inoculated into 100 mL of the culture formula obtained from the experimental design and incubated at different temperatures (20,25,30,35,40 and 50°C) for 7 days. Supernatant from each experiment was tested using the method of agar well diffusion agai nst C.albicans ATCC 10231 12 .…”

Section: Effect Of Temperature On the Production Of Antimicrobial Agentsmentioning

confidence: 99%

Antimicrobial Activity of Marine Actinomycetes and the Optimization of Culture Conditions for the Production of Antimicrobial Agent(s)

Hamed¹,

Abdelfattah²,

Fahmy³

2019

J Pure Appl Microbiol

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Citation: Moaz M. Hamed, Lamis Sh. Abdelfattah and Nayer M. Fahmy, Antimicrobial Activity of Marine Actinomycetes and the Optimization of Culture Conditions for the Production of Antimicrobial Agent(s), J Pure Appl Microbiol., 2019; 13(4):2177-2188. Abstract The aim of the present study was to isolate antagonistic actinomycetes from marine sediment collected from the Red Sea coast at Hurghada city and the Suez Gulf. A total of 16 actinomycete isolates were obtained in October 2018 and their antagonistic activities were evaluated against Aeromonas hydrophila, Vibrio damsela, Staphylococcus aureus ATCC6538, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 9027, Salmonella typhimurium ATCC 14028, Escherichia coli ATCC 19404 and Candida albicans ATCC 10231 by using the agar well diffusion method. Among the 16 isolates, 14 (87.5%) isolates exhibited antimicrobial activity against most of the tested pathogens. The most potent isolate was identified by 16S rRNA sequence analysis as Streptomyces sp. and designated Streptomyces sp. MK388207. The experimental design of Plackett-Burman was implemented to optimize the culture conditions for antimicrobial agent(s) production by the most powerful isolate against C. albicans ATCC 10231 when grown in starch nitrate broth and the data revealed that negative (-) levels of KNO 3 , K 2 HPO 4 and pH and positive (+) levels of starch, MgSO 4 .7H 2 O, FeSO 4 and incubation period supported the production of the antimicrobial agent(s). Growth under the optimized culture conditions led to a 1.4-fold rise in antimicrobial activity. The ethyl acetate extract of Streptomyces sp.MK388207 was subjected to gasliquid chromatography mass spectrometry (GC MS) and revealed the presence of six fractions with the major component being phenol, 2,4-bis (1,1 dimethylethyl). The findings of this study suggested that the antagonistic marine Streptomyces, in particular Streptomyces sp MK388207, the antibacterial compounds produced by this isolate, could be used as antibiotics that could have future applications in the pharmaceutical industry.

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“…Chandrasekar et al [23] showed that NimbapatradiChoornam had strong antimicrobial activity against Klebsiella pneumoniae, S. aureus, E. coli and Candida albican. The presence of phenol, 2,4-bis[1,1-dimethylethyl]-derivative, isopropyl myristate, eicosane, octadecanoic acid and hexadecanoic acid compounds were responsible for the antimicrobial activity of Nimbadipatrachoornam.…”

Section: Production Of Antibacterial Compound and Gc-ms Analysismentioning

confidence: 99%

GC–MS Analysis of Bio-active Molecules Derived from Paracoccus pantotrophus FMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs

Begum

Ramasamy

Jeevan³

et al. 2016

Indian J Microbiol

118

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The present investigation is focused on the study of chemical composition of a bioactive compound derived from a rumen isolate Paracoccus pantotrophus FMR19 using GC-MS and to find out the antibacterial activity of the extracted crude bioactive compounds against multidrug resistant organisms (MDROs) and other clinical pathogens. GC-MS analysis revealed that P. pantotrophus FMR19 produced eight major compounds that have been reported to exhibit antimicrobial property. The main components identified from hexane fraction are long chain alkanes, fatty alcohols, fatty acid methyl ester and aromatic hydrocarbons. These molecules are not only active against clinical pathogens such as Salmonella sp. and Proteus sp. and also effective against MDROs such as Metallo b lactamase and Pan drug resistant bacterial strains and Methicillin resistant Staphylococcus aureus.

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Liposomal Formulation of Turmerone-Rich Hexane Fractions fromCurcuma longaEnhances Their Antileishmanial Activity

Cited by 14 publications

References 42 publications

Mitigation of free radicals and carbohydrate-linked enzymes by extracts and partitioned fractions of Elephantorrhiza elephantina (Burch.) Skeels root

Mitigation of free radicals and carbohydrate-linked enzymes by extracts and partitioned fractions of Elephantorrhiza elephantina (Burch.) Skeels root

Antimicrobial Activity of Marine Actinomycetes and the Optimization of Culture Conditions for the Production of Antimicrobial Agent(s)

GC–MS Analysis of Bio-active Molecules Derived from Paracoccus pantotrophus FMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs

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