Liposomal gene delivery mediated by tissue-engineered scaffolds

Abstract

Publication informationTrends in Biotechnology, 28 (1): 28-36Publisher Elsevier Item record/more information http://hdl.handle.net/10197/5009 Publisher's statementThis is the author's version of a work that was accepted for publication in Trends in Biotechnology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Biotechnology (28, 1, (2010)

Liposomes in tissue engineering and regenerative medicine

“…However, the future of liposomes is not limited to those therapeutic applications. Liposomes, being a highly flexible platform, have been used in different areas of research including the production of vaccines, imaging, cosmetics and TE [27,36]. Herein, we will focus on lipids as a biomaterial and review some applications of the liposomes, mainly in TE and regenerative medicine.…”

“…It is expected that therapeutic nanoparticles, such as liposomes, offer the potential to dramatically improve the effectiveness and side-effect profile of new and existing bioactive agents [77]. Moreover, many tissue-engineered scaffolds have already been approved for human use [27]. Therefore, combining liposomes with scaffolds has the potential for clinical translation in the near future.…”

“…The combination of liposomes with scaffolds has been already reviewed elsewhere [15,27,108,117]. All these strategies aspire to combine the advantageous properties of liposomes and polymer matrices, aiming at developing materials that can sequester and maintain liposomes at a local tissue site.…”

Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model

“…37 Commercially available liposomes have demonstrated high cellular uptake efficiency and capacity in vitro tests. 38 However, in vivo applications, they are usually accompanied by unwanted regional and systemic toxicity. 39 Calcium phosphate nanoparticles represent a unique class of nonviral vectors that have attracted increasing attention as new candidates for nonviral vectors in gene therapy.…”

Scaffold‐Based microRNA Therapies in Regenerative Medicine and Cancer

“…The structural versatility of lipid-based vectors is of key value for adapting their use to different cargos as well as to target distinct cell types. [59] However, this is counterbalanced by their reported cytotoxic and proinflammatory effects, some of which have been associated with their ability to trigger the generation of intracellular vacuoles. [60] Polyethyleneimine (PEI) derivatives have also been extensively studied as miRNA delivery systems, [19,61,62] and specifically PEI-poly(ethylene glycol) (PEG) nanoparticles (NP) have recently demonstrated interesting profiles when encapsulated within poly(lactic-co-glycolic acid) (PLGA) microspheres in a poly(l-lactic acid) (PLLA) scaffold [63] or as part of a calcium chloride cross-linked alginate hydrogel system.…”