Liposomal Hydrogels: A Novel Drug Delivery System for Wound Dressing

Thirumaleshwar, Shailesh; Kulkarni, P. K.; Gowda, Devegowda Vishakante

doi:10.2174/157488512803988021

Cited by 21 publications

(15 citation statements)

References 43 publications

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Section: Resultsmentioning

confidence: 99%

“…Yet, this was not observed in our study. The rheological behavior of vesicles-in-hydrogel is highly influenced by the composition of carriers, lipid concentration, type of polymer, and polymer concentration [54]. Contrary to the effect of incorporation of vesicles into the hydrogel network, the temperature affected the rheological behavior of all hydrogels.…”

Section: Viscosity Evaluationmentioning

confidence: 99%

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Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

et al. 2021

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Burns and other skin injuries are growing concerns as well as challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing, are urgently needed for the timely treatment of infection-prone injuries. Treatment of acute skin injuries requires tailoring of formulation to assure both proper skin retention and the appropriate release of incorporated antimicrobials. The challenge remains to formulate antimicrobials with low water solubility, which often requires carriers as the primary vehicle, followed by a secondary skin-friendly vehicle. We focused on widely used chlorhexidine formulated in the chitosan-infused nanocarriers, chitosomes, incorporated into chitosan hydrogel for improved treatment of skin injuries. To prove our hypothesis, lipid nanocarriers and chitosan-comprising nanocarriers (≈250 nm) with membrane-active antimicrobial chlorhexidine were optimized and incorporated into chitosan hydrogel. The biological and antibacterial effects of both vesicles and a vesicles-in-hydrogel system were evaluated. The chitosomes-in-chitosan hydrogel formulation demonstrated promising physical properties and were proven safe. Additionally, the chitosan-based systems, both chitosomes and chitosan hydrogel, showed an improved antimicrobial effect against S. aureus and S. epidermidis compared to the formulations without chitosan. The novel formulation could serve as a foundation for infection prevention and bacterial eradication in acute wounds.

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Section: Resultsmentioning

confidence: 99%

Section: Viscosity Evaluationmentioning

confidence: 99%

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

et al. 2021

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“…To overcome these obstacles, not only PEGylated and other second-generation vesicles have been successfully designed 47 but also combining vesicle carriers within polymeric matrices have shown interesting therapeutic activities. 14,48 With this in mind, the aforementioned nioplexes were entrapped into thermoresponsive polysaccharide-based hydrogels made of either kcarrageenan 49 (KC) (4%; w/v) or a 1 : 1 mixture of methylcellulose : k-carrageenan 50 (MC :KC) (2% w/w) in the presence of HEPES buffer (20 mM, pH 7.4). Thus, a series of hydrogels in combination with niosomal formulations of FITC-ODN (1), Luc (2) and Scr (3) oligonucleotides (cationic nioplexes) were obtained: (a) Hydrogel_3, Hydrogel_5 and Hydrogel_7, which were only made of KC polymer and (b) Hydrogel_4, Hydrogel_6 and Hydrogel_8, which were exclusively made of the mixture MC:KC (Table 1).…”

Section: Formation and Characterization Of Cationic Nioplexesmentioning

confidence: 99%

Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

et al. 2017

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Two polysaccharide-based hydrogels made of only kcarrageenan (4%; w/v) or of a mixture of methylcellulose:kcarrageenan (2%; w/v) were used to encapsulate cationic nioplexes. These vesicular particles were made of a synthetic aminolipid and polysorbate-80 (Tween-80), as a non-ionic surfactant agent. According to oscillatory rheological measurements, the presence of nioplexes did not compromise the mechanical integrity of the gels. In vitro niosomal release experiments demonstrated the liberation of nioplexes up to 24 h, and the curves were fitted according to Higuchi, Korsmeyer-Peppas and Weibull equation models, which indicated Fickian-diffusion controlled mechanisms. Besides nioplexes, cervical cancer cells were also entrapped within the biohydrogels. Cell release confirmed that these materials did not affect the cell viability, allowing cells to spread and proliferate after 24 h. The applicability of these biocompatible hydrogels was also extended to gene delivery. In this regard, the best silencing activities were found when cationic niosomes were complexed with antisense oligonucleotides in KC hydrogels. Nioplexes were able to release through the hydrogel and promoted silencing of luciferase expression in the presence of serum without using commercially available cationic lipids. Overall, the formation of such hybrid materials by integrating cationic nioplexes within biodegradable hydrogels provides a new perspective for the delivery of macromolecular therapeutics.

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“…22 The first description of an artificial polymeric hydrogel was made in 1960 by Otto Wichterle and Drahoslav Lím who sought for a material with properties suitable for the production of new contact lenses. Nowadays, artificial hydrogels have gained importance in many sectors of life science and daily life such as contact lenses, 24 wound dressing, 25,26 super absorbers (diapers, packaging, construction industry), 27, 28 scaffolds for tissue engineering, 29 matrices for separation problems, 30 drug delivery devices 31 and sensors. Nowadays, artificial hydrogels have gained importance in many sectors of life science and daily life such as contact lenses, 24 wound dressing, 25,26 super absorbers (diapers, packaging, construction industry), 27, 28 scaffolds for tissue engineering, 29 matrices for separation problems, 30 drug delivery devices 31 and sensors.…”

Section: Poly(2-oxazoline) Hydrogelsmentioning

confidence: 99%

Covalently cross-linked poly(2-oxazoline) materials for biomedical applications – from hydrogels to self-assembled and templated structures

2015

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REVIEW This journal isCovalently cross-linked polymeric materials play an important role in life science. Hydrogels produced from multifunctional polymers can be utilized in numerous (bio)applications, such as drug delivery, tissue engineering and (bio)sensing. Also nano-/micro-scaled assemblies benefit from a covalent linkage for instance to prevent premature disassembly or to generate a passive tissue specifity when used as drug delivery agent. In both cases there is a need for biocompatible polymers with manifold (orthogonal) functionalization possibilities. By using the cationic ring-opening polymerization of 2-oxazolines it is possible to accomplish both tasks. In this review we summerize covalantly cross-linked structures consisting of poly(2-oxazoline)s including three dimensional scaffolds, micellar systems as well as multilayer capsules. We focus on the cross-linking chemistry and the impact of the addressed systems regarding biological application.

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Liposomal Hydrogels: A Novel Drug Delivery System for Wound Dressing

Cited by 21 publications

References 43 publications

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

Covalently cross-linked poly(2-oxazoline) materials for biomedical applications – from hydrogels to self-assembled and templated structures

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