Liposomal/Nanoliposomal Encapsulation of Food-Relevant Enzymes and Their Application in the Food Industry

Mohammadi, Adeleh; Jafari, Seid Mahdi; Mahoonak, Alireza Sadeghi; Ghorbani, Mohammad

doi:10.1007/s11947-020-02513-x

Cited by 44 publications

(21 citation statements)

References 78 publications

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“…LNPs are increasingly prominent in the food industry and in nutrition. − LNPs have been used to control the delivery of functional components such as proteins, enzymes, vitamins, and flavors in various food and nutritional applications. The term “nutraceutical” is used to describe formulations potentially providing both pharmaceutical and nutritional benefits. − These formulations may involve nutrients, dietary supplements, herbal preparations, and genetically engineered and processed foods.…”

Section: Applications Of Lipid Nanoparticlesmentioning

confidence: 99%

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

et al. 2021

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Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells. Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform. A number of liposomal drugs have been approved and applied to medical practice. Subsequent generations of lipid nanocarriers, such as solid lipid nanoparticles, nanostructured lipid carriers, and cationic lipid–nucleic acid complexes, exhibit more complex architectures and enhanced physical stabilities. With their ability to encapsulate and deliver therapeutics to specific locations within the body and to release their contents at a desired time, LNPs provide a valuable platform for treatment of a variety of diseases. Here, we present a landscape of LNP-related scientific publications, including patents and journal articles, based on analysis of the CAS Content Collection, the largest human-curated collection of published scientific knowledge. Rising trends are identified, such as nanostructured lipid carriers and solid lipid nanoparticles becoming the preferred platforms for numerous formulations. Recent advancements in LNP formulations as drug delivery platforms, such as antitumor and nucleic acid therapeutics and vaccine delivery systems, are discussed. Challenges and growth opportunities are also evaluated in other areas, such as medical imaging, cosmetics, nutrition, and agrochemicals. This report is intended to serve as a useful resource for those interested in LNP nanotechnologies, their applications, and the global research effort for their development.

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Section: Applications Of Lipid Nanoparticlesmentioning

confidence: 99%

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

et al. 2021

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“…Biocatalysts, including enzymes, play an important role in medical and food industries and biotechnology [ 37 , 38 ]. For biotechnological applications, of particular significance are increased stability and efficiency of enzymes and the possibility of their repeated use in biocatalysis, biotransformations, preparation of various products, etc.…”

Section: Encapsulation Of Proteinsmentioning

confidence: 99%

“…Incorporation of acetylcholinesterase and some other enzymes into liposomes made it possible to stabilize them and protect from the action of proteases [ 45 ]. The preparation and use of liposomes for the encapsulation of various enzymes in the food industry were considered in [ 37 ]. Modern technologies provide a combination of several biologically active substances on a single carrier to produce multienzyme complexes.…”

Section: Encapsulation Of Proteinsmentioning

confidence: 99%

Methods of Encapsulation of Biomacromolecules and Living Cells. Prospects of Using Metal–Organic Frameworks

et al. 2021

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The review discusses different methods of encapsulation and biomineralization of macromolecules and living cells. Main advantages and disadvantages of most commonly used carriers, matrices, and materials for immobilization of proteins, enzymes, nucleic acids, and living cells are briefly surveyed. Examples of delivery vehicles for multifunctional encapsulation of protein-like substances are presented. Particular attention is paid to prospects of using metal-organic frameworks in medicine and biotechnology.

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“…Of these, liposomes are well‐known and used extensively for their biodegradability, biocompatibility, and controlled release behavior (Pinilla et al, 2019). They are colloidal carriers assembled by amphiphilic molecules and are made predominantly by phospholipid membranes with a polar head and fatty acid chain groups (Mohammadi et al, 2021). Thus, the phospholipid bilayer membrane structure of liposomes ensures the effective entrapment of both hydrophilic and hydrophobic bioactive compounds (Li et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Release behavior of vitamin C nanoliposomes from starch–vitamin C active packaging films

Khuntia

Kumar

Premjit

2022

J Food Process Engineering

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Ascorbic acid (Vitamin C) is an essential nutrient that cannot be synthesized by the human body. It is highly susceptible to degradation in presence of air, light, and moisture. Hence, encapsulation techniques are employed to provide better stability under adverse conditions. The present study used the nanoliposome technique because of its biocompatibility and controlled release efficiency. Nanoliposomes containing vitamin C (VC) were prepared by the thin-layer dispersion technique followed by sonication at different phosphatidylcholine (PC) to stearic acid (SA) ratio, that is, 100:0,

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Liposomal/Nanoliposomal Encapsulation of Food-Relevant Enzymes and Their Application in the Food Industry

Cited by 44 publications

References 78 publications

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Methods of Encapsulation of Biomacromolecules and Living Cells. Prospects of Using Metal–Organic Frameworks

Release behavior of vitamin C nanoliposomes from starch–vitamin C active packaging films

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