Liposomal Phospholipid Preparations of Chloramphenicol for Ophthalmic Applications

Mahmoud, Sherif S.; Gehman, John D.; Azzopardi, Kristy; Robins-Browne, Roy M.; Separovic, Frances

doi:10.1002/jps.21201

Cited by 15 publications

(9 citation statements)

References 23 publications

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“…The spectrum displays the main characteristic bands, especially those due to the symmetric and antisymmetric PO 2 À stretching vibrations at 1137.8 cm À1 and 1297.86 cm À1 , respectively, the carbonyl stretching vibration C]O within the range of 1720-1740 cm À1 and the symmetric and antisymmetric stretching vibrations of the CH 2 in the acyl chain within the region of 2800-2855 cm À1 and 2920-2924 cm À1 , respectively. [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] The detailed spectral analyses are performed in ve distinct wavenumber regions, namely 3300-3050 cm À1 (Fig. 7B), 3050-2800 cm À1 (Fig.…”

Section: Ftir Resultsmentioning

confidence: 99%

Biophysical characterization of lutein or beta carotene-loaded cationic liposomes

2020

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Section: Ftir Resultsmentioning

confidence: 99%

Biophysical characterization of lutein or beta carotene-loaded cationic liposomes

2020

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“…CAP was localized in the interfacial lipid bilayers in the case of CAP-EN whereas entrapped deeper in the bilayers in the case of CAP-PART. These results showed that CAP located near the interfacial region within the hydrophobic core of the liposomes had shown highest anti-bacterial activity against S. aureus for almost 5 hrs [63]. …”

Section: Topical Applicationsmentioning

confidence: 99%

Recent Applications of Liposomes in Ophthalmic Drug Delivery

Mishra

Bagui

Tamboli

et al. 2011

Journal of Drug Delivery

179

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Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. Current approaches for topical delivery of liposomes are focused on improving the corneal adhesion and permeation by incorporating various bioadhesive and penetration enhancing polymers. In the case of posterior segment disorders improvement in intravitreal half life and targeted drug delivery to the retina is achieved by liposomes. In this paper we have attempted to summarize the applications of liposomes in the field of ophthalmic drug delivery by citing numerous investigators over the last decade.

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“…Mahmoud et al, (2008) studied dimyristoylphosphatidylcholine (DMPC) liposomes containing chloramphenicol. The liposomes were prepared using different ways and the efficacy against Staphylococcus aureus infection was measured.…”

Section: Antibacterial Drugsmentioning

confidence: 99%

Liposomes in topical ophthalmic drug delivery: an update

et al. 2014

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Topical route of administration is the most commonly used method for the treatment of ophthalmic diseases. However, presence of several layers of permeation barriers starting from the tear film till the inner layers of cornea make it difficult to achieve the therapeutic concentrations in the target tissue within the eye. In order to circumvent these barriers and to provide sustained and targeted drug delivery, tremendous advances have been made in developing efficient and safe drug delivery systems. Liposomes due to their unique structure prove to be extremely beneficial drug carriers as they can entrap both the hydrophilic and hydrophobic drugs. The conventional liposomes had several drawbacks particularly their tendency to aggregate, the instability and leakage of entrapped drug and susceptibility to phagocytosis. Due to this reason, for a long time, liposomes as drug delivery systems did not attract much attention of researchers and clinicians. However, over recent years development of new generation liposomes has opened up new approaches for targeted and sustained drug delivery using liposomes and has rejuvenated the interest of researchers in this field. In this review we present a summary of current literature to understand the anatomical and physiological limitation in achieving adequate ocular bioavailability of topically applied drugs and utility of liposomes in overcoming these limitations. The recent developments related to new generation liposomes are discussed.

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Liposomal Phospholipid Preparations of Chloramphenicol for Ophthalmic Applications

Cited by 15 publications

References 23 publications

Biophysical characterization of lutein or beta carotene-loaded cationic liposomes

Biophysical characterization of lutein or beta carotene-loaded cationic liposomes

Recent Applications of Liposomes in Ophthalmic Drug Delivery

Liposomes in topical ophthalmic drug delivery: an update

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