Liposome: a carrier for effective drug delivery

Abstract

Liposomes are the spherical vesicles containing one or more phospholipid bilayer, which was first described in the middle of 60s by Bangham. The bilayer vesicles are considered as an efficient carrier for drug delivery, diagnostic agents, and also an effective tool for vaccine delivery. Liposome has been used as a potential carrier for several diseases from cardiovascular disease to bacterial infection and also it has the ability to reducing the toxicity of highly potent drugs and simultaneously utilized to improve pharmacokinetics and therapeutic efficacy. A liposome is a formulation which has the capacity to overcome with the limitation of conventional therapies. For the delivery of liposome ocular and inhalation route are some advanced technology. In poorly water soluble substance pulmonary delivery is very much useful. However liposome based vaccines have been demonstrated in clinical trials and further progress in human trails. This review discusses the mechanism of action, Method of preparation, evaluation, application of liposomal drug delivery system along with the recent developments some of the commercially available products.

Liposomal Nanomedicine: Applications for Drug Delivery in Cancer Therapy

“…Ultimately, liposomes are synthesized following hydration and extrusion methods [39]. Other methods of liposome synthesis include sonication, reverse phase evaporation, French pressure cell, freeze-drying and, membrane extrusion [38,40].…”

“…Synthetic siRNAs can be utilized to target oncogenes and their mRNAs. Furthermore, siRNAs can be applied for targeting genes contributing to the Approved [38,134,135] carcinogenesis, proliferation, and metastasis of tumor cells or their resistance to standard chemotherapies and radiation [138]. Therefore, it has been considered a modern method for cancer therapy.…”

“…is used to solve lipids intended to form liposome membranes (with the desired molar ratio) in a round-bottom flask (RBF). For instance, hand-shaking is the primary procedure to synthesize MLVs [ 38 ]. During this procedure, which is also recognized as lipid film hydration, lipids are added to an organic solvent.…”

Liposomes – A Review

“…In this strategy vesicles substance are traded with scattering medium during breaking and resealing of phosphate lipid bilayer as they go through polycarbonate film and less weight is required here as the contrast with French weight cell at that point used to measure MLVs and LUVs. Finally, convoluted and nucleation trach films are framed [18] .…”

“…(E) Dried reconstituted vesicles: Here the preformed liposomes are rehydrated to an aqueous fluid containing an active ingredient which is followed by dehydration of the mixture [18] .…”