Liposome-amplified photoelectrochemical immunoassay for highly sensitive monitoring of disease biomarkers based on a split-type strategy

Zhuang, Junyang; Han, Bin; Li, Wenchao; Zhou, Jinfei; Liu, Kewei; Yang, Da‐Peng; Tang, Dianping

doi:10.1016/j.bios.2017.07.067

Cited by 74 publications

(37 citation statements)

References 33 publications

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“…The produced ascorbic acid donated an electron to the graphene/g-C3N4 nanohybrid based photoelectrode, provoking an increased photocurrent signal. A detection limit of 0.63 pg/mL was obtained with the proposed PEC method [17].…”

Section: Biomimetic Vesicles In Electrochemical Bioassaysmentioning

confidence: 92%

Biomimetic vesicles for electrochemical sensing

Lebègue

Farre

Jose

et al. 2018

Current Opinion in Electrochemistry

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Biomimetic vesicles, mainly composed of self-assembled bilayers of phospholipids, have attracted great attention for applications in the biosensor field over a number of decades, as a means to amplify the signal through encapsulated signal probes. In this review paper the most important developments in biomimetic vesicles for electrochemical biosensing within the last 2 years are presented, with a focus on the format of bioassays, their inclusion in microfluidic chip devices and their use in mimicking cell membranes. Key issues and the remaining challenges for future commercialization are analyzed.

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Section: Biomimetic Vesicles In Electrochemical Bioassaysmentioning

confidence: 92%

Biomimetic vesicles for electrochemical sensing

Lebègue

Farre

Jose

et al. 2018

Current Opinion in Electrochemistry

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“…Micro/nanovesicles are excellent carriers not only of bioreagents but also detectable molecules (even nanomaterials) that enable signal amplification . The implementation of multiple functions into single micro/nanostructure (for example multifunctional nanoparticles or hybrid structures) is, however, a big challenge.…”

Section: Recognition Elements Amplification Methods and Sensor Intementioning

confidence: 99%

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

et al. 2019

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Disposable sensors are low‐cost and easy‐to‐use sensing devices intended for short‐term or rapid single‐point measurements. The growing demand for fast, accessible, and reliable information in a vastly connected world makes disposable sensors increasingly important. The areas of application for such devices are numerous, ranging from pharmaceutical, agricultural, environmental, forensic, and food sciences to wearables and clinical diagnostics, especially in resource‐limited settings. The capabilities of disposable sensors can extend beyond measuring traditional physical quantities (for example, temperature or pressure); they can provide critical chemical and biological information (chemo‐ and biosensors) that can be digitized and made available to users and centralized/decentralized facilities for data storage, remotely. These features could pave the way for new classes of low‐cost systems for health, food, and environmental monitoring that can democratize sensing across the globe. Here, a brief insight into the materials and basics of sensors (methods of transduction, molecular recognition, and amplification) is provided followed by a comprehensive and critical overview of the disposable sensors currently used for medical diagnostics, food, and environmental analysis. Finally, views on how the field of disposable sensing devices will continue its evolution are discussed, including the future trends, challenges, and opportunities.

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“…These characteristics indicate that miRNAs are potential biomarkers for diagnostic purposes. miRNAs are related to the occurrence and development of diseases and are pathologically specific; therefore, altered miRNA expression has been used for early detection and diagnosis, classification, prognosis, and predictive diagnosis [120][121][122][123][124].…”

Section: Rca Assay For Nucleic Acidsmentioning

confidence: 99%

Rolling Circle Amplification as an Efficient Analytical Tool for Rapid Detection of Contaminants in Aqueous Environments

Zhang

Cao

et al. 2021

Biosensors

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Environmental contaminants are a global concern, and an effective strategy for remediation is to develop a rapid, on-site, and affordable monitoring method. However, this remains challenging, especially with regard to the detection of various contaminants in complex water environments. The application of molecular methods has recently attracted increasing attention; for example, rolling circle amplification (RCA) is an isothermal enzymatic process in which a short nucleic acid primer is amplified to form a long single-stranded nucleic acid using a circular template and special nucleic acid polymerases. Furthermore, this approach can be further engineered into a device for point-of-need monitoring of environmental pollutants. In this paper, we describe the fundamental principles of RCA and the advantages and disadvantages of RCA assays. Then, we discuss the recently developed RCA-based tools for environmental analysis to determine various targets, including heavy metals, organic small molecules, nucleic acids, peptides, proteins, and even microorganisms in aqueous environments. Finally, we summarize the challenges and outline strategies for the advancement of this technique for application in contaminant monitoring.

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Liposome-amplified photoelectrochemical immunoassay for highly sensitive monitoring of disease biomarkers based on a split-type strategy

Cited by 74 publications

References 33 publications

Biomimetic vesicles for electrochemical sensing

Biomimetic vesicles for electrochemical sensing

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

Rolling Circle Amplification as an Efficient Analytical Tool for Rapid Detection of Contaminants in Aqueous Environments

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