Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine

The immunological activity of propolis flavonoids liposome on the immune response against ND vaccine

“…Adjuvants can promote T-cell proliferation [34] and stimulate cell-mediated immunity. Lymphocyte proliferation is an important index reflecting the cell-mediated immunity [35]. Cell-mediated immunity can exert the actions of anti-infection, anti-tumor, helping lymphocyte produce antibody by sensitized lymphocyte against corresponding antigen [36].…”

Mixture of polysaccharide and nucleic acid extracted from Bacillus Calmette-Guerin (BCG) enhances immune response of infectious bursal disease virus vaccine in chickens

“…The cytokine proteins IFN-γ and IL-2 are secreted by Th1 cells and can promote the proliferation and differentiation of T cells, which are always regarded as an important indicator of cellular immunity function (Farrar and Schreiber, 1993;Li et al, 2004;Fan et al, 2012). Moreover, it has been reported that IFN-γ and IL-2 can be used as adjuvants to enhance antigen presentation, T cell immune response and B cell humoral immune response (Lowenthal et al, 1998;Li et al, 2004;Kumar et al, 2009).…”

“…This result correlated with the increase in CD4+/CD8+ T ratio. The cytokine protein IL-6 is secreted by Th2 cells and can promote the proliferation of B cells and the production of antibody, which plays an important role in humoral immunity (Belardelli, 1995;Fan et al, 2012). In the present study, the concentrations of serum IL-6 in the 0.3 mg·kg -1 ·day -1 BCG-PSN group on day 5, and in the 0.075, 0.15 and 0.3 mg·kg -1 ·day -1 BCG-PSN groups on days 15 and 25 after vaccination were significantly higher than those in the negative control and vaccine groups, indicating that BCG-PSN could enhance huromal immunity.…”

“…Therefore, it is necessary to find an effective adjuvant to overcome these problems. At present, most research focuses on an immunopotentiator such as polyinosinic:polycytidylic acid (poly I:C) and Chinese herbal medicine (Hill, 1984;Fan et al, 2012). It can enhance immunity activities of animals themselves or synergistically enhance the immune effect of vaccine or act as an adjuvant to enhance the immune effect of the vaccine.…”

Immune-enhancing activity comparison of sulfated ophiopogonpolysaccharide and sulfated jujube polysaccharide

“…commonly used chemical adjuvants there are often more or less disadvantages [4]. Chinese herbal medicinal polysaccharides, as a kind of novel adjuvant, possess the characteristics of little side effects, lower toxicity and stimulatory which can meet the request of people for food safety [5].…”