Liposome‐Boosted Peroxidase‐Mimicking Nanozymes Breaking the pH Limit

Chen, Qiaoshu; Liu, Yibo; Li, Jianbo; Liu, Juewen

doi:10.1002/chem.202004133

Cited by 33 publications

(23 citation statements)

References 56 publications

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“…It acts as a hydrogen donor for the reduction of H 2 O 2 to water, resulting in deep blue color during the enzymatic degradation of H 2 O 2 by HRP. [ 19,20 ] Therefore, we used HRP redox reaction driven TMB color development to evaluate the H 2 O 2 production ability of EGCG and MEN. We first used UV–vis spectroscopy to verify H 2 O 2 production of EGCG solution at the designated time points (1, 4, 12 h).…”

Section: Resultsmentioning

confidence: 99%

Ferric Ions as a Catalytic Mediator in Metal‐EGCG Network for Bactericidal Effect and Pathogenic Biofilm Eradication at Physiological pH

Chen

Yan

et al. 2021

Adv Materials Inter

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animals has contributed to the emergence and spread of antibiotic resistance (i.e., microbes that develop resistance to the drugs used to treat them). [3,4] Meanwhile, overuse of antibiotics, in turn, further leads to serious environmental pollution. [5] To adapt to natural environment, microbes, especially bacteria, tend to adhere to the contact surface, secrete polysaccharide matrix, fibrin, lipid protein, and other substances, and wrap themselves, forming bacterial biofilm. [6] According to the estimation from National Institutes of Health (NIH), 80% of bacterial infections are related to the formation of bacterial biofilm. Compared with free bacteria, it is 10-1000 times higher in antibiotic resistance with bacterial biofilm, which is the main cause of bacterial resistance. [7] Until now, new antimicrobial drugs are constantly being developed to combat various types of microbes, while there is limited benefit to antimicrobial misuse problem. [8] Therefore, it is extremely urgent to develop new antimicrobial drugs that are highly efficient, environmentally friendly, and able to avoid the emergence of drug resistance. The development of nanomaterials provides an opportunity for the development of new antimicrobial drugs. Nanosilver, titanium dioxide, copper oxide, and many other nanomaterials have good antimicrobial activities. Some of them can even overcome microbial resistance. [9,10] However, most nanomaterials are not biocompatible. For example, although nanosilver has already been added to some sanitation supplies, the serious biological safety issues are still existed. [11] Green tea extracts (i.e., polyphenol catechins) have been linked to a variety of health benefits, such as antioxidation, antibacterial, antitumor, antiinflammation, and anticardiovascular diseases. Epigallocatechin gallate (EGCG) as the most abundant catechin displays strong antioxidant activity, which can efficiently eliminate reactive oxygen species (ROS). [12][13][14] Arakawa et al. reported that EGCG could react with dissolved oxygen in alkaline aqueous solution and act as a prooxidant, self-oxidation by producing hydrogen peroxide (H 2 O 2 ). [15] The mechanism of H 2 O 2 production was illustrated as follows: 1) H + was released from EGCG and superoxide was formed by Pathogenic bacteria and biofilm formation have become the urgent threats to global public health. Herein, metal-epigallocatechin gallate (EGCG) network with improved bactericidal effect and pathogenic biofilm eradication ability via trivalent cationic Fe 3+ catalyzed hydrogen peroxide (H 2 O 2 ) decomposition is developed. EGCG, the predominant catechin from tea, is predicted to be a good chelator for eight metal ions (i.e.

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Section: Resultsmentioning

confidence: 99%

Ferric Ions as a Catalytic Mediator in Metal‐EGCG Network for Bactericidal Effect and Pathogenic Biofilm Eradication at Physiological pH

Chen

Yan

et al. 2021

Adv Materials Inter

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“…Efforts related to exploring the potential of peroxidase-like nanozymes not only focused on expanding the primary application but also on improving the catalytic properties of the nanozymes to decrease the impact coming from the reaction conditions. Chen et al designed negatively charged liposome-boosted, peroxidase-mimicking nanozymes to exhibit the activity in even alkaline conditions [ 89 ]. Zhao et al found that DNA modification made the activity 4.3-times higher compared with that of bare MoS 2 nanosheets [ 90 ] lending further support to the value of using peroxidase-like nanozymes.…”

Section: Nanozyme Classification and Their Catalytic Mechanismsmentioning

confidence: 99%

Nanozymes—Hitting the Biosensing “Target”

Darland

Zhao

2021

Sensors

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Nanozymes are a class of artificial enzymes that have dimensions in the nanometer range and can be composed of simple metal and metal oxide nanoparticles, metal nanoclusters, dots (both quantum and carbon), nanotubes, nanowires, or multiple metal-organic frameworks (MOFs). They exhibit excellent catalytic activities with low cost, high operational robustness, and a stable shelf-life. More importantly, they are amenable to modifications that can change their surface structures and increase the range of their applications. There are three main classes of nanozymes including the peroxidase-like, the oxidase-like, and the antioxidant nanozymes. Each of these classes catalyzes a specific group of reactions. With the development of nanoscience and nanotechnology, the variety of applications for nanozymes in diverse fields has expanded dramatically, with the most popular applications in biosensing. Nanozyme-based novel biosensors have been designed to detect ions, small molecules, nucleic acids, proteins, and cancer cells. The current review focuses on the catalytic mechanism of nanozymes, their application in biosensing, and the identification of future directions for the field.

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“…Recently, however, the possibility of regulating their auxiliary properties, such as lipophilicity, stereospecificity, and the ability to respond to destination-specific stimuli, has gained increasing importance. Similar to natural enzymes, the activities of nanozymes can be tuned by many factors, such as pH [25,26], temperature [26], surrounding environment [27], and the type of the metal ion [26]. One class of such easily tunable substances are organometallic frameworks (MOFs).…”

Section: A Short History Of Nanozymesmentioning

confidence: 99%

Metal Nanozymes: New Horizons in Cellular Homeostasis Regulation

2021

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Nanomaterials with enzyme-like activity (nanozymes) have found applications in various fields of medicine, industry, and environmental protection. This review discusses the use of nanozymes in the regulation of cellular homeostasis. We also review the latest biomedical applications of nanozymes related to their use in cellular redox status modification and detection. We present how nanozymes enable biomedical advances and demonstrate basic design strategies to improve diagnostic and therapeutic efficacy in various diseases. Finally, we discuss the current challenges and future directions for developing nanozymes for applications in the regulation of the redox-dependent cellular processes and detection in the cellular redox state changes.

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Liposome‐Boosted Peroxidase‐Mimicking Nanozymes Breaking the pH Limit

Cited by 33 publications

References 56 publications

Ferric Ions as a Catalytic Mediator in Metal‐EGCG Network for Bactericidal Effect and Pathogenic Biofilm Eradication at Physiological pH

Ferric Ions as a Catalytic Mediator in Metal‐EGCG Network for Bactericidal Effect and Pathogenic Biofilm Eradication at Physiological pH

Nanozymes—Hitting the Biosensing “Target”

Metal Nanozymes: New Horizons in Cellular Homeostasis Regulation

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