Liposome-embedded, polymeric scaffold for extended delivery of galantamine

Mufamadi, Maluta Steven; Kumar, Pradeep; Toit, Lisa C. du; Choonara, Yahya E.; Obulapuram, Prasanna Kumar; Modi, Girish; Naidoo, Dinesh; Iyuke, Sunny E.; Pillay, Viness

doi:10.1016/j.jddst.2019.02.001

Cited by 15 publications

(4 citation statements)

References 26 publications

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“…Material degradation directly impacts liposomal drug release, so the system imparts sustained yet tunable release profiles. Similarly, Mufamadi et al (2019) developed a chitosan‐based hydrogel loaded with liposomal galantamine for the treatment of Alzheimer's disease, and found that degradation, liposome size, and gel porosity influence drug release. Gels with increased porosity, hydration rate, and swelling exhibited faster release kinetics.…”

Section: Nanocarrier‐hydrogel Composite Materials Offer Unique Advant...mentioning

confidence: 99%

Nanocarrier‐hydrogel composite delivery systems for precision drug release

Kass

Nguyen

2021

WIREs Nanomed Nanobiotechnol

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Hydrogels are a class of biomaterials widely implemented in medical applications due to their biocompatibility and biodegradability. Despite the many successes of hydrogel‐based delivery systems, there remain challenges to hydrogel drug delivery such as a burst release at the time of administration, a limited ability to encapsulate certain types of drugs (i.e., hydrophobic drugs, proteins, antibodies, and nucleic acids), and poor tunability of geometry and shape for controlled drug release. This review discusses two main important advances in hydrogel fabrication for precision drug release: first, the incorporation of nanocarriers to diversify their drug loading capability, and second, the design of hydrogels using 3D printing to precisely control drug dosing and release kinetics via high‐resolution structures and geometries. We also outline ongoing challenges and discuss opportunities to further optimize drug release from hydrogels for personalized medicine. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Nanocarrier‐hydrogel Composite Materials Offer Unique Advant...mentioning

confidence: 99%

Nanocarrier‐hydrogel composite delivery systems for precision drug release

Kass

Nguyen

2021

WIREs Nanomed Nanobiotechnol

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“…Currently, in the demand for precision medicine, how to achieve personalised drug release has become the research focus [ 24 ]. Changing the microstructure of the hydrogel and chemical modification are the two main approaches.…”

Section: Introductionmentioning

confidence: 99%

Topological Optimisation Structure Design for Personalisation of Hydrogel Controlled Drug Delivery System

Gao

Meng

et al. 2023

Materials

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Personalised controlled drug delivery systems (CDDSs) can adjust drug concentration levels according to patient needs, which has enormous research prospects in precision medicine. In this study, the topological optimisation method was utilised in the structural design of a hydrogel CDDS to achieve a parameter-based adjustment of the drug average concentration in the hydrogel. A polyacrylamide/sodium alginate dual-network hydrogel was selected as a drug carrier, and tetracycline hydrochloride was used as a model drug. The topological optimisation model of the hydrogel CDDS was developed. The effects of the mesh size, target concentration, and volume factor on the optimised results were investigated. Hydrogel flow channel structures were obtained, which satisfied the different target concentrations. To verify the rationality of the optimisation model, in vitro drug release experiments were carried out. The results show that the hydrogel CDDS can control drug release within 7 days, and the drug release tends to follow zero-order release behaviour. The adjustable average concentration of tetracycline hydrochloride in hydrogel CDDS is recommended in the range of 20.79 to 31.04 mol/m3. This novel method provides a reference for personalised structure design of CDDS in the context of precision medicine.

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“…in order to induce controlled release of the bioactives [ 76 , 77 ]. A number of particulate-based approaches have been recently carried out for bioactive delivery from scaffolds; for instance, from PLGA [ 78 , 79 ], gelatin [ 80 ], alginate [ 81 ], silica-based [ 82 , 83 ] particles, as well as liposomes [ 84 , 85 ], etc. These carriers can be integrated into the pre-fabricated scaffolds or integrated during the assembly of the scaffolds [ 86 ].…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering

et al. 2020

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Tissue engineering (TE) is a highly multidisciplinary field that focuses on novel regenerative treatments and seeks to tackle problems relating to tissue growth both in vitro and in vivo. These issues currently involve the replacement and regeneration of defective tissues, as well as drug testing and other related bioapplications. The key approach in TE is to employ artificial structures (scaffolds) to support tissue development; these constructs should be capable of hosting, protecting and releasing bioactives that guide cellular behaviour. A straightforward approach to integrating bioactives into the scaffolds is discussed utilising polyelectrolyte multilayer capsules (PEMCs). Herein, this review illustrates the recent progress in the use of CaCO3 vaterite-templated PEMCs for the fabrication of functional scaffolds for TE applications, including bone TE as one of the main targets of PEMCs. Approaches for PEMC integration into scaffolds is addressed, taking into account the formulation, advantages, and disadvantages of such PEMCs, together with future perspectives of such architectures.

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Liposome-embedded, polymeric scaffold for extended delivery of galantamine

Cited by 15 publications

References 26 publications

Nanocarrier‐hydrogel composite delivery systems for precision drug release

Nanocarrier‐hydrogel composite delivery systems for precision drug release

Topological Optimisation Structure Design for Personalisation of Hydrogel Controlled Drug Delivery System

Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering

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