Liposome imaging agents in personalized medicine

Petersen, Anncatrine Luisa; Hansen, Anders Elias; Gabizón, Alberto; Andresen, Thomas Lars

doi:10.1016/j.addr.2012.09.003

Cited by 147 publications

(111 citation statements)

References 152 publications

Supporting

Mentioning

111

Contrasting

Order By: Relevance

“…For example, folate derivatives , transferrin (Bellocq et al, 2003), or epidermal growth factor receptor (EGFR)-related molecules (El-Sayed et al, 2006;Magadala and Amiji, 2008) may be surface localized on nanocarriers to facilitate interaction with their respective receptor targets, which frequently display distinct expression patterns at the tumor site. The most commonly used techniques for modern imaging of nanocarriers are positron emission tomography or single photon emission computed tomography, which make use of a growing arsenal of radiolabeled compounds (Petersen et al, 2012). However, optical approaches such as fluorescence, infrared spectroscopy, and ultrasound are also widely used in experimental or clinical settings (Kozlowska et al, 2009).…”

Section: Novel Strategies To Inhibit P-glycoproteinmentioning

confidence: 99%

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

2014

View full text Add to dashboard Cite

P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous attempts to inhibit the protein and restore the efficacy of anticancer drugs. The general strategy has been to develop compounds that either compete with anticancer drugs for transport or act as direct inhibitors of P-gp. Despite considerable in vitro success, there are no compounds currently available to "block" P-gp-mediated resistance in the clinic. The failure may be attributed to toxicity, adverse drug interaction, and numerous pharmacokinetic issues. This review provides a description of several alternative approaches to overcome the activity of P-gp in drug-resistant cells. These include 1) drugs that specifically target resistant cells, 2) novel nanotechnologies to provide high-dose, targeted delivery of anticancer drugs, 3) compounds that interfere with nongenomic transfer of resistance, and 4) approaches to reduce the expression of P-gp within tumors. Such approaches have been developed through the pursuit of greater understanding of resistance mediators such as P-gp, and they show considerable potential for further application.

show abstract

Section: Novel Strategies To Inhibit P-glycoproteinmentioning

confidence: 99%

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

2014

View full text Add to dashboard Cite

show abstract

“…Using liposomes for MRI requires a balance between blood circulation time, time required for accumulation and retention of nanoparticles in the plaque and blood clearance rates. The latter is important to reduce background signal for imaging (18 In contrast, iron oxide nanoparticle loaded liposomes produce local magnetic susceptibility, which results in a distance dependent dephasing of hydrogen nuclei. Such superparamagnetic liposomal contrast agents have a thousand times higher magnetic moments compared to paramagnetic gadolinium containing ones, therefore improving sensitivity tremendously (19).…”

Section: Liposomes -"Nanofat" Carriers For Anti-inflammatory Actionmentioning

confidence: 99%

“…Such superparamagnetic liposomal contrast agents have a thousand times higher magnetic moments compared to paramagnetic gadolinium containing ones, therefore improving sensitivity tremendously (19). For nuclear medicine, liposomes are radiolabeled with 64 Cu, 68 Ga or 18 F for positron emission tomography (PET), while 67 Ga and 111 In are frequently used radiolabels for single photon emission computed tomography (SPECT) (19).…”

Section: Liposomes -"Nanofat" Carriers For Anti-inflammatory Actionmentioning

confidence: 99%

Anti-inflammatory mediators for molecular imaging of atherosclerosis

Almer

Opriessnig

Ruth³

et al. 2014

European Journal of Nanomedicine

View full text Add to dashboard Cite

Nanomedicine, a young and innovative field, offers interesting approaches for diagnosis and treatment in personalized medicine. Myocardial infarction and stroke belong to the most important challenges in this context because an improved early diagnosis of individuals well before fatal clinical endpoints occur is urgently needed. The underlying cause of myocardial infarction and stroke is atherosclerosis, a chronic immune-mediated inflammation of the vascular wall involving monocytes, macrophages, T-lymphocytes, and arterial wall cells. Hence, an immense number of pro-inflammatory mediators have been investigated in the context of nanomedicine and atherosclerosis but, interestingly, only few anti-inflammatory biomarkers. Nevertheless, the anti-inflammatory axis is always present as a negative feedback if a critical inflammatory perpetuation destabilizes atherosclerotic lesions. Hence, we could show that the immune-modulating, antiinflammatory molecules, adiponectin and interleukin-10, are useful for molecular imaging of AS plaques. Based on recent publications in animal models of atherosclerosis, we strongly assume that the inflammatory "brake" mechanisms may represent an interesting new tool to specifically target the scenario of culprit AS-lesions. In this review article we discuss the potential of adiponectin, interleukin-10 and other anti-inflammatory active molecules like targeted liposomes and high dense lipoproteins towards this.

show abstract

“…Besides their use as drug delivery systems, recently, the liposomes were considered in order to develop patient personalized therapies, to learn about genetic makeup of the subject and how the specific tumour is evolving [116][117][118]. By this way prevention, screening and treatment strategies should be more effective and the side effects reduced.…”

Section: Multifunctional Liposomesmentioning

confidence: 99%

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

et al. 2016

View full text Add to dashboard Cite

Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient. To this scope, due to their unique features, nanostructured materials have emerged as attractive elements for the development of multifunctional tools for diagnosis and therapy. Hence, in this review, the most recent and relevant advances achieved by applying multifunctional nanostructures in multimodal theranosis of different diseases will be discussed. In more detail, the preparation and application of single multifunctional nano-radiotracers based on iron oxides and enabling PET/MRI dual imaging will be firstly detailed. After that, especially considering their highly promising clinical potential, the preparation and application of multifunctional liposomes useful for multimodal imaging and therapy will be reviewed. In both cases, a special focus will be set on the application of such a multifunctional nanocarriers in cancer as well as cardiovascular diseases.

show abstract

Liposome imaging agents in personalized medicine

Cited by 147 publications

References 152 publications

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

Anti-inflammatory mediators for molecular imaging of atherosclerosis

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

Contact Info

Product

Resources

About