Liposome preparation using a hollow fiber membrane contactor—Application to spironolactone encapsulation

Laouini, A.; Jaafar‐Maalej, Chiraz; Sfar, Sana; Charcosset, Catherine; Fessi, Hatem

doi:10.1016/j.ijpharm.2011.05.034

Cited by 132 publications

(69 citation statements)

References 48 publications

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“…However, higher influx of PCL into the aqueous phase leads to higher supersaturation, which explains why the Zaverage only slightly increased from 196 to 200 nm. Similar trends were observed for other NPs formed in membrane contactors [30,41,45,46].…”

Section: Effect Of Agitation Speed Of Aqueous Phasesupporting

confidence: 83%

“…Microfabricated pore arrays are similar to massively parallel T junctions, through which one fluid may be introduced into another at an overall much higher flow rate than is possible in individual channels [29]. The mixing rate can 4 be enhanced by providing a controlled shear at the membrane surface using cross flow [30], stirring [23], flow pulsations [31], radially or axially oscillating membrane tube [32,33], and rotating membrane [24]. However, the role of different pore arrangements, pore shapes and fabrication methods on the performance of microfabricated membrane in micromixing process…”

Section: Graphical Abstractmentioning

confidence: 99%

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Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Othman

Vladisavljević

Shahmohamadi

et al. 2016

Chemical Engineering Journal

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Section: Effect Of Agitation Speed Of Aqueous Phasesupporting

confidence: 83%

Section: Graphical Abstractmentioning

confidence: 99%

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Othman

Vladisavljević

Shahmohamadi

et al. 2016

Chemical Engineering Journal

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“…Spironolactone (SP) falls into this group due to its very low aqueous solubility and slow dissolution rate resulting in a variable and poor oral bioavailability (1)(2)(3)(4)(5)(6). SP has widely been used over the last two decades to primarily treat edema, hypertension and cutaneous disorders (e.g.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability

et al. 2016

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Abstract.Stable solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) formulations to enhance the dissolution rates of poorly soluble drug spironolactone (SP) were being developed. Probe ultra-sonication method was used to prepare SLNs and NLCs. All NLCs contained stearic acid (solid lipid carrier) and oleic acid (liquid lipid content), whereas, SLNs were prepared and optimised by using the solid lipid only. The particles were characterised in terms of particle size analysis, thermal behaviour, morphology, stability and in vitro release. The zeta sizer data revealed that the increase in the concentration of oleic acid in the formulations reduced the mean particle size and the zeta potential. The increase in concentration of oleic acid from 0 to 30% (w/w) resulted in a higher entrapment efficiency. All nanoparticles were almost spherically shaped with an average particle size of about ∼170 nm. The DSC traces revealed that the presence of oleic acid in the NLC formulations resulted in a shift in the melting endotherms to a higher temperature. This could be attributed to a good long-term stability of the nanoparticles. The stability results showed that the particle size remained smaller in NLC compared to that of SLN formulations after 6 months at various temperatures. The dissolution study showed about a 5.1-to 7.2-fold increase in the release of the drug in 2 h compared to the raw drug. Comparing all nanoparticle formulations indicated that the NLC composition with a ratio of 70:30 (solid:liquid lipid) is the most suitable formulation with desired drug dissolution rates, entrapment efficiency and physical stability.

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“…25) Furthermore, the SPI-loaded liposomes were only stable at 5°C. 26) In Vitro Release of SPI and NI from Cubosomes The in vitro release profiles of SPI and NI are shown in Fig. 3.…”

Section: Characterization Of Spi-and Ni-loaded Cubosomesmentioning

confidence: 99%

Enhancing the Solubility and Oral Bioavailability of Poorly Water-Soluble Drugs Using Monoolein Cubosomes

et al. 2017

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Monoolein cubosomes containing either spironolactone (SPI) or nifedipine (NI) were prepared using a high-pressure homogenization technique and characterized in terms of their solubility and oral bioavailability. The mean particle size, polydispersity index (PDI), zeta potential, solubility and encapsulation efficiency (EE) values of the SPI-and NI-loaded cubosomes were determined to be 90.4 nm, 0.187, 13.4 mV, 163 µg/mL and 90.2%, and 91.3 nm, 0.168, 12.8 mV, 189 µg/mL and 93.0%, respectively, which were almost identical to those of the blank cubosome. Small-angle X-ray scattering analyses confirmed that the SPI-loaded, NIloaded and blank cubosomes existed in the cubic space group Im3 m. The lattice parameters of the SPI-and NI-loaded cubosomes were 147.6 and 151.6 Å, respectively, making them almost identical to that of blank cubosome (151.0 Å). The in vitro release profiles of the SPI-and NI-loaded cubosomes showed that they released less than 5% of the drugs into various media over 12-48 h, indicating that most of the drug remained encapsulated within the cubic phase of their lipid bilayer. Furthermore, the in vivo pharmacokinetic results suggested that these cubosomes led to a considerable increase in the systemic oral bioavailability of the drugs compared with pure dispersions of the same materials. Notably, the stability results indicated that the mean particle size and PDI values of these cubosomes were stable for at least 4 weeks. Taken together, these results demonstrate that monoolein cubosomes represent promising drug carriers for enhancing the solubility and oral bioavailability of poorly water-soluble drugs.Key words cubosome; drug carrier; monoolein; nifedipine; spironolactone; high-pressure homogenizationThe low oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. A wide variety of formulation approaches, including lipid nanoparticles, solid dispersions, complexes with cyclodextrin or chitosan-alginates, nanoemulsions and liposomes, have been used to enhance the solubility and bioavailability of several poorly water-soluble drugs. [1][2][3][4][5] Cubosomes have recently attracted considerable interest from formulation scientists in terms of their potential application as drug delivery systems based on their highly ordered, compartmentalized internal structures, high lipid content and large surface area.Cubosomes are inverse bicontinuous cubic lyotropic crystalline nanoparticles that can be loaded with poorly water-soluble drugs in their three-dimensional cubic phases, leading to pronounced increases in the solubility, stability and bioavailability of these drugs.6-9) Cubosomes can be prepared using nontoxic, biocompatible and biodegradable ingredients, and can be readily used to encapsulate lipophilic drugs. Monoolein is a common amphiphilic building block for the preparation of cubosomes, 10) and is relatively cheap compared with other commonly used lipid excipients such as phytantriol. Nonionic triblock copolymer (Pluronic F-127) is ...

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Liposome preparation using a hollow fiber membrane contactor—Application to spironolactone encapsulation

Cited by 132 publications

References 48 publications

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability

Enhancing the Solubility and Oral Bioavailability of Poorly Water-Soluble Drugs Using Monoolein Cubosomes

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