Liposomes and Niosomes

Wen, Jingyuan; Gailani, Murad Al; Yin, Naibo; Rashidinejad, Ali

doi:10.1002/9781119247159.ch10

Cited by 10 publications

(5 citation statements)

References 66 publications

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“…Both have efficiency in encapsulating hydrophilic and hydrophobic drugs at the aqueous layer and the lipid bilayer, respectively. However, liposomes are less suitable because of their instability due to oxidation or hydrolysis of phospholipids, they need special storage conditions in a dark area sealed with nitrogen, and the materials used to produce liposomes are expensive [17]. Nonionic surfactants are commonly used in the preparation of niosomes due to their high degree of compatibility with other ingredients.…”

Section: Introductionmentioning

confidence: 99%

Aerosolized Niosome Formulation Containing Gemcitabine and Cisplatin for Lung Cancer Treatment: Optimization, Characterization and In Vitro Evaluation

et al. 2021

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Gemcitabine (Gem) and cisplatin (Cis) are currently being used for lung cancer treatment, but they are highly toxic in high dosages. This research aimed to develop a niosome formulation containing a low-dosage Gem and Cis (NGC), as an alternative formulation for lung cancer treatment. NGC was prepared using a very simple heating method and was further optimized by D-optimal mixture design. The optimum NGC formulation with particle size, polydispersity index (PDI), and zeta potential of 166.45 nm, 0.16, and −15.28 mV, respectively, was obtained and remained stable at 27 °C with no phase separation for up to 90 days. The aerosol output was 96.22%, which indicates its suitability as aerosolized formulation. An in vitro drug release study using the dialysis bag diffusion technique showed controlled release for both drugs up to 24 h penetration. A cytotoxicity study against normal lung (MRC5) and lung cancer (A549) cell lines was investigated. The results showed that the optimized NGC had reduced cytotoxicity effects against both MRC5 and A549 when compared with the control (Gem + Cis alone) from very toxic (IC50 < 1.56 µg/mL) to weakly toxic (IC50 280.00 µg/mL) and moderately toxic (IC50 = 46.00 µg/mL), respectively, after 72 h of treatment. These findings revealed that the optimized NGC has excellent potential and is a promising prospect in aerosolized delivery systems to treat lung cancer that warrants further investigation.

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Section: Introductionmentioning

confidence: 99%

Aerosolized Niosome Formulation Containing Gemcitabine and Cisplatin for Lung Cancer Treatment: Optimization, Characterization and In Vitro Evaluation

et al. 2021

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“…Niosomes are vesicles formed as a result of unfavorable interactions between nonionic surfactants and water molecules resulting in closed bilayer structures and can also encapsulate lipophilic, hydrophilic and amphiphilic compounds [ 319 ]. Niosomes are preferred over liposomes as they offer better mucosal permeability, sustained and site-specific release, higher stability and are cost-effective [ 320 ]. Niosomes promise higher chemical stability, simultaneous encapsulation of hydrophilic and hydrophobic bioactive compounds and reduced toxicity due to their nonionic nature [ 321 ].…”

Section: Delivery Systems For β-Carotenementioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

et al. 2021

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Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers have some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has rapidly evolved, with a plethora of innovative nanoengineered materials now being in use, including micelles, nano/microemulsions, liposomes, niosomes, solidlipid nanoparticles, nanostructured lipids and nanostructured carriers. These nanodelivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nanodelivery systems adopted for developing functional foods, depicting their classifications, compositions, preparation methods, challenges, release and absorption of β-carotene in the gastrointestinal tract (GIT) and possible risks and future prospects.

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“…Niosomes are vesicles formed as a result of unfavorable interactions between s nonionic surfactants and water molecules resulting in closed bilayer structures and can also encapsulate lipophilic, hydrophilic and amphiphilic compounds [237]. Niosomes are preferred over liposomes as they offer better mucosal permeability, sustained and site-specific release and higher stability and are cost effective [238]. Niosomes promise higher chemical stability, simultaneous encapsulation of hydrophilic and hydrophobic bioactive compounds and reduced toxicity due to their nonionic nature [237].…”

Section: Niosomesmentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Maurya¹,

Shakya²,

Aggarwal³

et al. 2021

Preprint

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Accruing evidence on the influence of β-carotene regarding the prevention of several chronic diseases - in addition to its well-acknowledged role in vision has been a strong driver for developing alternative delivery systems. Though oral delivery is accepted as the most fitting, mild and safe path for delivering bioactive agents, β-carotene delivery via food items poses challenges due to its lipophilic nature, poor water-solubility, high chemical/photochemical instability and poor oral bioavailability. Nanotechnology has opened new windows for delivering bioactive agents. Their physiochemical characteristics, i.e. small size, high surface area, unique composition, biocompatibility and biodegradability make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers inherit some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has been rapidly evolved, with a plethora of innovative nano-engineered materials, including micelles, nano/microemulsion, liposomes, niosomes, solid-lipid nanoparticles and nanostructured lipid carriers. These nano-delivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nano-delivery systems adopted for developing functional foods: depicting their classification, composition, preparation methods, challenges, release-and absorption of β-carotene in the GIT and possible risks and future prospects.

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Liposomes and Niosomes

Cited by 10 publications

References 66 publications

Aerosolized Niosome Formulation Containing Gemcitabine and Cisplatin for Lung Cancer Treatment: Optimization, Characterization and In Vitro Evaluation

Aerosolized Niosome Formulation Containing Gemcitabine and Cisplatin for Lung Cancer Treatment: Optimization, Characterization and In Vitro Evaluation

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

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