Liposomes and PEGylated liposomes as drug delivery system

Mohamed, Marwa; Alaaeldin, Eman; Hussein, Amal K.; Sarhan, Hatem A.

doi:10.21608/jabps.2020.22937.1068

Cited by 8 publications

(15 citation statements)

References 67 publications

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“…The improvement in the healthy state of this group is indicative that the PEGylated CNTs could reduce inflammation in ischemic stroke leading to a healthy state of the rat. This also implies that PEG facilitated the delivery of the CNTs to the ischemic site [ 32 ]. From the results obtained, it could be deduced that CNTs have a beneficial role in the healing of stroke.…”

Section: Resultsmentioning

confidence: 99%

Atrial Natriuretic Peptide Antibody-Functionalised, PEGylated Multiwalled Carbon Nanotubes for Targeted Ischemic Stroke Intervention

2021

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Stroke is one of the major causes of disability and the second major cause of death around the globe. There is a dire need for an ultrasensitive detection tool and an effective and efficient therapeutic system for both detection and treatment of stroke at its infancy stage. Carbon nanotubes are promising nanomaterials for tackling these challenges. The loading of dexamethasone and decoration of PEGylated multiwalled carbon nanotube with atrial natriuretic peptide (ANP) antibody and fluorescein isothiocyanate for targeting ischemic site in the rat stroke model is presented here. Functionalisation of carbon nanotubes with dexamethasone (DEX), polyethylene glycol (PEG), fluorescein isothiocyanate (FITC), and ANP antibody caused a 63-fold increase in the D band intensity as illustrated by Raman. The characteristic band intensity increase was observed at 1636 nm following functionalisation of carbon nanotubes with polyethylene glycol and dexamethasone as confirmed by Fourier Transform Infrared. These findings have demonstrated the coupling capability of atrial natriuretic peptide antibody to DEX-PEG-CNTs. The baseline plasma atrial natriuretic peptide levels were ranging from 118 to 135.70 pg/mL prior to surgery and from 522.09 to 552.37 following common carotid artery occlusion. A decrease in atrial natriuretic peptide levels to 307.77 was observed when the rats were treated with FITC-DEX-PEG-ANP-CNTs, PEG-CNTs and DEX with a significant drop in the FITC-DEX-PEG-ANP-CNTs treated group. Fluorescence was detected in FITC-DEX-PEG-CNTs and FITC-DEX-PEG-ANP-CNTs treated ischemic stroke rats. The highest fluorescence intensity was reported in plasma (2179) followed by the kidney (1563) and liver (1507). These findings suggest a beneficial role that is played by the FITC-DEX-PEG-ANP-CNTs in the reduction of inflammation in the ischemic stroke induced rats that could induce a successful treatment of ischemic stroke.

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Section: Resultsmentioning

confidence: 99%

Atrial Natriuretic Peptide Antibody-Functionalised, PEGylated Multiwalled Carbon Nanotubes for Targeted Ischemic Stroke Intervention

2021

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“…przyłączanie polimerów czy ligandów. Preparaty oparte na liposomach stają się wtedy bardziej neutralne dla organizmu, a ich zastosowanie bardziej wydajne [9][10][11][12].…”

Section: źRódło: Opracowanie Własneunclassified

“…Ograniczeniem w stosowaniu liposomów konwencjonalnych okazała się odpowiedź immunologiczna organizmu -po podaniu preparatu dochodziło do szybkiej eli- minacji podanej substancji z krwi. Doprowadziło to do ograniczenia stosowania tego typu liposomów na rzecz tych ze zmodyfikowaną otoczką, które nie są tak szybko wykrywane i usuwane przez składniki układu odpornościowego [7,9,10,21]. Dobrym zamiennikiem dla liposomów konwencjonalnych okazały się liposomy stabilizowane sterycznie, które w swojej otoczce zawierają dodatkowy związek, najczęściej jest to polimer -glikol polietylenowy PEG.…”

Section: Klasyfikacja Liposomów W Oparciu O Budowę Otoczkiunclassified

PEGylated (modified with polyethylene glycol) liposomes – their structures and properties

Pieczara¹,

Starosta²

2023

Aesth Cosmetol Med

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Liposomes are nanocarriers consisting of a phospholipid bilayer, similar in composition and structure to a cell membrane. Such a feature provides several possibilities related to the transport and delivery of biologically active substances to the specific cells in organisms. It is now becoming more and more popular to modify lipid carrier shells to achieve higher specificity and efficiency of transport into cells, and to reduce immunogenicity. The article aimed to present the properties, characteristics and application of liposomes modified with polyethylene glycol (PEG). The most common modification is a coating of liposomes with PEG, then sterically stabilized PEGylated vesicles are formed. PEGylation is currently a pillar of liposomal technologies due to the high efficiency of this type of nanocarrier and the possibility of attaching ligands to polymer chains. This article presents the characteristics of liposomes as carriers of substances, their structures, and types of cell interactions with a special emphasis on PEGylated liposomes.

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“…Cholesterol is added to increase the liposomal membrane fluidity, and polyethylene glycol (PEG) is added to increase the stability of liposomes in circulation and are commonly known as PEGylated liposomes. PEG protects liposomes from macrophages engulfment (by keeping the macrophages away from the liposomes) , - by probability 50% of the PEG molecules are inside the liposomes are 50% are outside. In addition, the type of phospholipid used determines the surface-charge of the liposome, and it has been shown that neutral liposomes (such as DOPC) help avoid rapid macrophage engulfment as well. , Although roto-evaporation is the conventional method used to prepare liposomes, for therapeutic applications, where the liposome formulation must be sterile, the freeze-drying method is preferred …”

Section: Experimental Sectionmentioning

confidence: 99%

A Fresh Look at the Potential of Cyclodextrins for Improving the Delivery of siRNA Encapsulated in Liposome Nanocarriers

et al. 2022

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Liposomes are among the most effective vehicles to deliver siRNAs to cells, both in vitro and in vivo. However, despite numerous efforts to improve the potential of liposomes, siRNAs begin to leach out of liposomes as soon as they are formulated. This decreases the value of liposomes for drug delivery purposes significantly, masking their true potential. In this study, we examine the effect of β-cyclodextrins on the retention time and transfection efficiency of siRNAs formulated in a liposome. Cyclodextrins have been widely studied as solvating agents and drug delivery vectors mainly because these cyclic nontoxic glucose structures can bind several molecules of different physicochemical characteristics, through H-bonding or by forming inclusion complexes. These properties, although beneficial for most applications, have resulted in some contradictory results published in the literature, whereas cyclodextrins have been found to destabilize a liposome's membrane. Here, we present a systematic study, which shows that βcyclodextrin binds, possibly via hydrogen bonding, with siRNA and DOPC liposomes, resulting in increased siRNA serum stability and in vitro siRNA's transfection efficiency when formulated together.

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Liposomes and PEGylated liposomes as drug delivery system

Cited by 8 publications

References 67 publications

Atrial Natriuretic Peptide Antibody-Functionalised, PEGylated Multiwalled Carbon Nanotubes for Targeted Ischemic Stroke Intervention

Atrial Natriuretic Peptide Antibody-Functionalised, PEGylated Multiwalled Carbon Nanotubes for Targeted Ischemic Stroke Intervention

PEGylated (modified with polyethylene glycol) liposomes – their structures and properties

A Fresh Look at the Potential of Cyclodextrins for Improving the Delivery of siRNA Encapsulated in Liposome Nanocarriers

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