2005
DOI: 10.1016/j.jconrel.2004.11.020
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Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle–skin interaction

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Cited by 290 publications
(123 citation statements)
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“…The content of MX in MTS and TFS were significantly higher than CLP, indicating that the thermodynamic activity of MX in MTS and TFS formulation was important for its promotion of MX permeation flux through the skin. The positive charge of elastic vesicles (MTS and TFS) might affect the skin permeability and skin deposit 30) as positive charge of vesicle interacted with negative charge of skin, thus MTS showed higher skin deposit than TFS because MTS has a greater positive charge than TFS. Table 2 shows the significant difference of elasticity between MTS and TFS formulation.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The content of MX in MTS and TFS were significantly higher than CLP, indicating that the thermodynamic activity of MX in MTS and TFS formulation was important for its promotion of MX permeation flux through the skin. The positive charge of elastic vesicles (MTS and TFS) might affect the skin permeability and skin deposit 30) as positive charge of vesicle interacted with negative charge of skin, thus MTS showed higher skin deposit than TFS because MTS has a greater positive charge than TFS. Table 2 shows the significant difference of elasticity between MTS and TFS formulation.…”
Section: Resultsmentioning
confidence: 99%
“…Liposomes are one of potential strategies that utilize for skin delivery of hydrophilic drugs, 3) lipophilic drugs, 4) protein 5) and macromolecule. 6) Although last decades, some design of conventional liposomes are of little or no value as carriers for transdermal drug delivery, but rather remain confined to the upper layer of the stratum corneum.…”
Section: Hcl)mentioning
confidence: 99%
“…Sistemas de liberação do tipo lipossomas para veiculação do ácido retinóico têm sido desenvolvidos por diversos autores até o momento (MONTENEGRO et al, 1996;BRISAERT et al, 2001;MANCONI et al, 2002;SHIMIZU et al, 2003;CONTRERAS et al, 2005;SINICO et al, 2005). Microemulsões tem sido o veículo de escolha utilizado por alguns autores (TROTTA et al, 2003;HUANG et al, 2004).…”
Section: Estabilidade Do áCido Retinóicounclassified
“…To increase MX accumulation in the skin layers in recent years different vesicular systems have been investigated. Lipid vesicles are reported to enhance topical drug delivery, with a reduction of the dose applied [4][5][6][7][8][9][10][11][12]. In the attempt to find new vesicular formulations able to optimize MX cutaneous delivery, in a previous work we prepared and characterized new liposomal systems prepared by using in their composition a few penetration enhancers (PEs) which differ for chemical structure and physicochemical properties [14].…”
Section: Introductionmentioning
confidence: 99%