Liposomes as Drug Delivery Vehicles

Wang, Guijun

doi:10.1002/9781118833322.ch13

Cited by 5 publications

(1 citation statement)

References 135 publications

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“…Unfortunately, there are disadvantages to conventional liposomal carriers, the most prominent being rapid clearance from the blood and chemical and physical instability [17]. Thus, clear advances have been made recently in the development of stabilized liposomes.…”

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confidence: 99%

Organic Nanoparticles: Adapting Emerging Techniques from the Electronics Industry for the Generation of Shape‐Specific, Functionalized Carriers for Applications in Nanomedicine

Euliss

Dupont

DeSimone

2007

Nanobiotechnology II

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The design and exploitation of materials and structures where at least one dimension is measured in the nanometer range broadly defines the term ''nanotechnology'' [1]. The umbrella of nanotechnology covers a wide variety of research disciplines, ranging from nanomachines to lithography to the development of nanoparticles (NPs). Nanomedicine is therefore the natural extension of nanotechnology implemented in the medical field. The National Institutes of Health (NIH) have recently coined the term ''Nanomedicine'' to mean the application of nanotechnology for the treatment, diagnosis, monitoring, and control of biological systems [2]. At the forefront of research in this area is the development of methods to target and deliver pharmaceutically-relevant cargo and diagnostic and imaging agents. One of the current trends in nanomedicine materials development is toward tunable monodisperse nanostructures, and considerable effort has been devoted to the design and fabrication of these materials. However, it is clear that the scientific community has only ''scratched the surface'' with respect to the ability to control and fabricate complex nanostructures with control over composition, shape, and function.The use of nanostructures as noninvasive imaging agents -referred to as ''nanodiagnostics'' -is one current area of research in nanomedicine. Here, ''smart-particles'' are prepared with the goal of detecting diseases at the earliest stages [3]. As these nanomaterials decrease in size, both their physical and chemical properties are subject to dramatic change, which often makes them amenable diagnostic agents. Examples include colloidal gold [4], iron oxide crystals [5], quantum dots (CdSe/ZnS) [6], and NPs that contain image-active cargos (Gdbased) [7]. For example, Huang and co-workers have described the use of gold nanorods of a specific aspect ratio that absorb and scatter strongly in the nearinfrared region. These nanorods are conjugated to anti-epidermal monoclonal antibodies and can be used simultaneously for molecular imaging and photother-285 Nanobiotechnology II. Edited by Chad A. Mirkin and Christof M. Niemeyer

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confidence: 99%

Organic Nanoparticles: Adapting Emerging Techniques from the Electronics Industry for the Generation of Shape‐Specific, Functionalized Carriers for Applications in Nanomedicine

Euliss

Dupont

DeSimone

2007

Nanobiotechnology II

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Boron‐Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides

Bregadze

Sivaev

Dubey

et al. 2020

Chemistry A European J

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As eries of boron-containing lipids werep repared by reactions of cyclic oxonium derivatives of polyhedron boranesa nd metallacarboranes (closo-dodecaborate anion, cobalt and iron bis(dicarbollides)) with amine and carboxylic acids which are derived from cholesterol. Stable liposomal formulations,o nt he basis of synthesized boron-containing lipids, hydrogenated soybean l-a-phosphatidylcholinea nd (HSPC) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG) as excipients,w ere prepared and then characterizedb yd ynamic light scattering(DLS) that revealed the formation of particles to be smaller than 200 nm in diameter.T he resulting liposomal formulationss howed moderate to excellent loading and entrapmente fficiency, thus justifying the design of the compounds to fit in the lipid bilayer and ensuringease of in vivo use for futurea pplication. The liposomalf ormulations based on cobalt and iron bis(dicarbollide)-based lipids were found to be nontoxic against both human breast normale pithelial cells MCF-10A and human breast cancer cells MCF-7.

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Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

et al. 2021

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To combat the rise of antibiotic resistant bacteria, it is essential to look upon other therapeutic solutions that do not solely depend upon conventional antibiotics. Here, we have designed a combinational therapeutic approach that kills bacteria with the conjunction of photothermal (PT) and antibiotic therapy. A near‐infrared (NIR) laser activated targeted drug delivery nano‐assembly delivers antibiotic as well as offer PT therapy (PTT). The synergistic application of both therapies increases the efficacy of treatment. The protected delivery of antibiotic and its release in the proximity of the bacteria surface reduces off‐target toxicity and reduce the efficacious dosage. Core of the nano‐assembly is composed of NIR active gold nanorods (GNRs) coated with a mesoporous silica nanoparticle (MSNP), which serves as a carrier for an anti‐tuberculosis drug bedaquiline (BDQ). The assembly was wrapped within a thermo‐sensitive liposome (TSL) conjugated to mycobacteria‐targeting peptide: NZX, GNR@MSNP@BDQ@TSL@NZX. NZX mediates adhesion of final nano‐assembly on mycobacteria surface. Upon NIR laser irradiation GNRs convert photo energy of the laser to localized heat, which melts TSL triggering release of BDQ. Antibacterial activity of final nano‐assembly against Mycobacterium smegmatis (Msmeg) was 20 folds more efficacious than the free drug equivalent. The final nano‐assembly could also successfully inhibit the growth of intracellular mycobacteria residing in lung cells.

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Liposomes as Drug Delivery Vehicles

Cited by 5 publications

References 135 publications

Organic Nanoparticles: Adapting Emerging Techniques from the Electronics Industry for the Generation of Shape‐Specific, Functionalized Carriers for Applications in Nanomedicine

Organic Nanoparticles: Adapting Emerging Techniques from the Electronics Industry for the Generation of Shape‐Specific, Functionalized Carriers for Applications in Nanomedicine

Boron‐Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides

Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

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