Liposomes as Potential Drug Carrier Systems for Drug Delivery

Çağdaş, Melis; Sezer, Ali Demir; Bucak, Şeyda

doi:10.5772/58459

Cited by 140 publications

(102 citation statements)

References 203 publications

(205 reference statements)

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“…[28] In this line, PEGylation (poly (ethylene) glycol) could improve liposomal circulation half-life in vivo through reduction of clearance and recognition by immune system as well as the restriction of non-specific absorption of serum proteins. [44] Several liposome-based vectors (e.g., Allovectin-7 R , USA) have been used in clinical trials for cancer therapy. [21] Figure 1 shows the use of lipofection for gene therapy against different diseases in clinical trials.…”

Section: Lipid-based Non-viral Vectorsmentioning

confidence: 99%

Different strategies of gene delivery for treatment of cancer and other disorders

Agi

Mosaferi

Khatamsaz

et al. 2016

JST

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Gene therapy is the gene transfer into host cells for treatment of acquired and genetic disorders. For this purpose, there are a wide variety of gene delivery methods with special properties including viral and non-viral vectors. The non-viral methods use physical forces or chemical compounds (natural or synthetic) to transfer DNA into a cell. The efficiency of the non-viral gene therapy depends on conquering four different intra-and extra-cellular barriers such as cellular uptake, endosomal escape, nuclear entry, and gene expression. Among various gene carriers, some viral vectors such as Adenovirus, Lentivirus, Vaccinia as well as gene gun and lipofection achieved to clinical trials. In this mini-review, we briefly describe different approaches for gene delivery and their applications in various phases of clinical trials.

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Section: Lipid-based Non-viral Vectorsmentioning

confidence: 99%

Different strategies of gene delivery for treatment of cancer and other disorders

Agi

Mosaferi

Khatamsaz

et al. 2016

JST

View full text Add to dashboard Cite

show abstract

“…4) The size, type and delivery method of the liposomes must be determined in accordance with the desired target (active or passive targeting) for the intended application [204][205][206]. [195, Since the classical methods are limited for industrial-scale production of liposomes, a few liposome preparation methods have been improved to provide active targeting.…”

Section: Liposome Preparation Methodsmentioning

confidence: 99%