Liposomes for delivery of antioxidants in cosmeceuticals: Challenges and development strategies

Tran, Vinh Van; Moon, Ju‐Young; Lee, Young-Chul

doi:10.1016/j.jconrel.2019.03.003

Cited by 164 publications

(64 citation statements)

References 274 publications

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“…Antioxidant activity is one of the most important features to evaluate the applicability of plant extracts [35,36]. Although O. humifusa contains an abundance of antioxidant components that are excellent candidates for cosmetic applications, it has not been widely applied as a cosmetic ingredient due to its high viscosity [17].…”

Section: Discussionmentioning

confidence: 99%

Effects of Microwave-Assisted Opuntia humifusa Extract in Inhibiting the Impacts of Particulate Matter on Human Keratinocyte Skin Cell

et al. 2020

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Particulate matter (PM) is one of the most important factors causing serious skin diseases, due to its generation of reactive oxygen species (ROS) over the course of long-term exposure. As a source of natural antioxidants, Opuntia humifusa (O. humifusa) is a potential candidate for the design of advanced formulations to prevent PM’s harmful effects. Unfortunately, its high viscosity does not allow it to be utilized in these formulations. In this present study, a new approach to the extract of O. humifusa using high-power microwave treatment, namely microwave-assisted O. humifusa extract (MA-OHE), was investigated. The results indicated that MA-OHE not only is a reasonable viscosity extract, but also enhances O. humifusa’s antioxidant properties. Additionally, this study also found that MA-OHE exhibited outstanding antioxidant and anti-inflammatory activities in eliminating PM’s effects, due to suppression of AhR degradation, ROS production, and COX-2 and MMP-9 expression in HaCaT keratinocytes. It is believed that MA-OHE is a potential cosmeceutical ingredient that could be utilized to prevent PM-induced skin oxidative stress and inflammation.

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Section: Discussionmentioning

confidence: 99%

Effects of Microwave-Assisted Opuntia humifusa Extract in Inhibiting the Impacts of Particulate Matter on Human Keratinocyte Skin Cell

et al. 2020

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“…Apart from industrial production, on a laboratory scale, the bulk thin film hydration (TFH) and ethanol injection (EI) techniques are the most exploited for liposomes fabrication to be used in cosmetics [35]. The THF method, through the use of a rotary evaporator, provides the dissolution of the lipids in an organic solvent and its consequent evaporation under vacuum leading to the formation of a lipid film which, after a hydration step, gives lipid micrometric vesicles.…”

Section: Manufacturing Issuesmentioning

confidence: 99%

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Bochicchio¹,

Dalmoro

Simone

et al. 2020

Cosmetics

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Novel nanotechnologies represent the most attractive and innovative tools to date exploited by cosmetic companies to improve the effectiveness of their formulations. In this context, nanoliposomes have had a great impact in topical preparations and dermocosmetics, allowing the transcutaneous penetration and absorption of several active ingredients and improving the stability of sensitive molecules. Despite the recent boom of this class of delivery systems, their industrial production is still limited by the lack of easily scalable production techniques. In this work, nanoliposomes for the topical administration of vitamin D3, K2, E, and curcumin, molecules with high antioxidant and skin curative properties but unstable and poorly absorbable, were produced through a novel simil-microfluidic technique. The developed high-yield semi continuous method is proposed as an alternative to face the problems linked with low productive conventional methods in order to produce antioxidant formulations with improved features. The novel technique has allowed to obtain a massive production of stable antioxidant vesicles of an 84–145 nm size range, negatively charged, and characterized by high loads and encapsulation efficiencies. The obtained products as well as the developed high-performance technology make the achieved formulations very interesting for potential topical applications in the cosmetics/cosmeceutical field.

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“…The oil phase chiefly constitutes synthetic as well as natural fatty acids and lipids, oils including medium to long chain triglycerides, and perflurochemicals. 39,40 The primarily utilized emulsifiers and co-emulsifiers comprise both natural and synthetically modified lecithin, PEG-conjugated castor oil derivatives (Cremophore EL), poly (ethylene oxide) (PEO)containing block copolymers, glycerides, surfactants, such as sorbitan alkyl ester, disodium stearoyl glutamate, sucrose alkyl ester, and cationic lipids. 41 Moreover, the final nanoformulation also includes buffers, flavors, antioxidants, and preservatives.…”

Section: Nanoemulsionsmentioning

confidence: 99%

Emerging trends in nanomedicine for topical delivery in skin disorders: Current and translational approaches

Pandey

Satija

Wadhwa

et al. 2020

Dermatologic Therapy

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A drug can be administered topically in a localized manner anywhere in the body through various routes including ophthalmic, rectal, vaginal, and skin. 1 Being the largest organ of the human body, the skin performs various functions including protection from the external environment, it serves as the first line of defense against the entry of microorganisms and chemicals, and provides a barrier to the loss of salts and fluids which helps in regulating body temperature. 2 It performs numerous indispensable capacities, including insurance against outside physical, substance and biologic attackers, just as avoidance of overabundance water loss from the body and a role in thermoregulation. The skin is persistent, with the mucous layers coating the body's surface. The skin is principally mesodermal in its embryonic induction. Specific skin cells and structures are shaped from 3 to 6 months of gestation. 3

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Liposomes for delivery of antioxidants in cosmeceuticals: Challenges and development strategies

Cited by 164 publications

References 274 publications

Effects of Microwave-Assisted Opuntia humifusa Extract in Inhibiting the Impacts of Particulate Matter on Human Keratinocyte Skin Cell

Effects of Microwave-Assisted Opuntia humifusa Extract in Inhibiting the Impacts of Particulate Matter on Human Keratinocyte Skin Cell

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Emerging trends in nanomedicine for topical delivery in skin disorders: Current and translational approaches

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