Liposomes from polymerizable phospholipids

Hupfer, B.; Ringsdorf, Helmut; Schupp, H.

doi:10.1016/0009-3084(83)90028-2

Cited by 88 publications

(64 citation statements)

References 41 publications

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“…Therefore, we propose that in the liposomes formulations sensitive to UV-triggered photo-crosslinking and calcein leakage, DC 8,9 PC remains immiscible with DPPC (Fig. 1A), consistent with monolayer studies of lipids with similar compositions [22,23]. Natural leakage of calcein (no radiation) from these liposomes was negligible when incubated at various temperatures (data not shown).…”

Section: Resultssupporting

confidence: 80%

Design of liposomes containing photopolymerizable phospholipids for triggered release of contents

Yavlovich

Singh

Tarasov

et al. 2009

J Therm Anal Calorim

135

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We describe a novel class of light-triggerable liposomes prepared from a photo-polymerizable phospholipid DC8,9PC (1,2- bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine) and DPPC (1,2-Dipalmitoyl-sn-Glycero-3-Phosphocholine). Exposure to UV (254 nm) radiation for 0–45 minutes at 25°C resulted in photo-polymerization of DC8,9PC in these liposomes and the release of an encapsulated fluorescent dye (calcein). Kinetics and extents of calcein release correlated with mol% of DC8,9PC in the liposomes. Photopolymerization and calcein release occurred only from DPPC/DC8,9PC but not from Egg PC/DC8,9PC liposomes. Our data indicate that phase separation and packing of polymerizable lipids in the liposome bilayer are major determinants of photo-activation and triggered contents release.

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Section: Resultssupporting

confidence: 80%

Design of liposomes containing photopolymerizable phospholipids for triggered release of contents

Yavlovich

Singh

Tarasov

et al. 2009

J Therm Anal Calorim

135

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“…The synthesis and property investigations of the phosphatidylcholine-analogue-containing polymers and phospholipid polymers are of increasing interest, not only because the famous membrane model of Singer and Nicolson, which pictures a double layer formed by a lipid matrix and proteins, but also because phospholipids are the most abundant among the lipids found in membranes [26]. During the past three decades, several groups focused their interest and attention on the polymerizable phospholipids, e.g., Nakaya et al [27][28][29][30][31][32][33][34][35][36][37][38][39], Regen et al [40][41][42][43], Ringsdorf et al [44][45][46][47][48], Chapman et al [49][50][51][52][53][54][55][56], O'Brien et al [57][58][59], Tsuchida et al [60], Singh et al [61] and Ishihara [62] have incorporated many polymerizable groups into various lipid structures to prepare phospholipid polymers and investigate their properties and potential applications.…”

Section: Aibnmentioning

confidence: 99%

Recent progress of phospholipid polymers

Nakaya¹,

Li²

2003

Designed Monomers and Polymers

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Since in 1982 the rst phosphatidylcholineanalogues-containingvinyl monomer 2-(methacryloyloxy)ethyl-2-(trimethylammonium)ethyl phosphate (MTP) was reported, more and more attention has focused on its polymers, as phospholipid polymers have been found to show excellent biocompatibility. We reviewed the progress of phospholipid polymers in 1997 which covered literature from 1974 to 1997; and mainly focused on phosphatidylcholineanalogues-containingvinyl polymers. This review re ects mainly recent research (i.e., mostly later than 1997) and important development progress on polymeric polyphospholipid analogues. A variety of approaches for design, synthesis, characterization, property investigation and potential applications for phospholipid-analoguecontaining polyurethanes and 2-methacryloyloxyethylphosphorylcholine-containing polymers have been extensivelydiscussed. The polymeric phospholipid analogues include polymers such as side-and main-chain types of phosphatidylcholine-analogue-containing polyurethanes, side-and main-chain types of phosphatidylcholine-analogue-containing segmented polyurethanes, phosphatidylcholineanalogue-grafted polyurethanes, 2-methacryloyloxyethylphosphorylcholine-containing polymers, 2-methacryloyloxyethylphosphorylcholine-modi ed acrylamide hydrogel, etc. Design and synthesis of phosphatidylcholine-analogue-containing diols and their polyurethanes with various commercially available diisocyanates and phosphatidylcholine-analogue surface-modi ed polyurethanes are described. New ring-opening reagents such as 2-dimethylaminoethanol for the main-chain type of phosphatidylcholine-analogue-containing polyurethanes, N -methyldiethanolamine for the sidechain type of phosphatidylcholine-analogue-containing polyurethanesand trimethylamine for grafting phosphatidylcholine-analogue-containing vinyl monomers are discussed. A general reaction route to design and synthesize phosphatidylcholine-analogue-containing diols and polyurethanes is summarized. Various phosphatidylcholine-analogue-containing segmented polyurethanes are also discussed. Various phosphatidylcholine-analogue-containing diols, together with 1,4-butanediol or ethylenediamine as chain extender were used to synthesize phosphatidylcholine-analogue-containing segmented polyurethanes or polyurethaneureas, which are based on diphenylmethane diisocyanate and various types of soft segments such as a polycarbonate,polyether, polyester and hydrocarbon diols. Character-310 T. Nakaya and Y. Li ization techniques for phosphatidylcholine-analogue-containing polyurethanes and polymers are also described. These include infra-red spectroscopy, 1 H-NMR, viscosity and gel-permeation chromatography measurements for bulk property; X-ray diffraction methods for structure; dynamic viscoelasticity and tensile measurements for mechanical properties. Moreover, attenuated total re ectanceFourier transform infrared spectroscopy,electron spectroscopy for chemical analysis and contact angle measurements for surface properties are all described. Hemocompatibility ...

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“…25). Like the muconates 5 and 8, 14 shows the formation of a new band at 220 nm on irradiation with the unfiltered lamp B. This band decreases by irradiation with lamp A (polymer II).…”

Section: Polymerization Of Bifunctional Amphiphi/es In Multi/ayersmentioning

confidence: 99%

Polymerization of hydrocarbon and fluorocarbon amphiphiles in Langmuir-Blodgett multilayers

1985

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Liposomes from polymerizable phospholipids

Cited by 88 publications

References 41 publications

Design of liposomes containing photopolymerizable phospholipids for triggered release of contents

Design of liposomes containing photopolymerizable phospholipids for triggered release of contents

Recent progress of phospholipid polymers

Polymerization of hydrocarbon and fluorocarbon amphiphiles in Langmuir-Blodgett multilayers

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