Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

The role of lipoxins in cardiometabolic physiology and disease

“…Inflammation plays a crucial role in atherosclerotic plaque formation and CVD, as outlined above, and the therapeutic potential of LXs has been highlighted as they may promote the resolution of atherosclerotic plaques and increase plaque stability [2,19,27,40,65] (Fig. 1).…”

“…Importantly, this phase does not automatically dissipate after the initial injury has been resolved, but rather an active resolution must be initiated [19,40]. Inflammatory resolution is regulated by SPMs: the ω3-polyunsaturated fatty acid (PUFA)-derived protectins, resolvins and maresins, and the ω6-PUFAderived LXA 4 and LXB 4 [19,41,42].…”

“…Importantly, such therapeutic approaches would likely have few side effects and provide long-term safety with respect to CVD. The ω3-PUFA-derived SPMs attenuate obesity-induced adipose inflammation and related liver disease [54][55][56][57][58] as well as many features of CVD (for review articles, see [22,40,59,60]). Similarly, AnxA1 correlates with reduced adipose inflammation and protects against nonalcoholic steatohepatitis [61,62].…”

Is Prior Aspirin Use Associated with Reduced Severity in Patients with Acute Pancreatitis?

“…Aspirin, a NSAID, has a broad spectrum of clinical indications due to its analgesic, antipyretic, anti-inflammatory, and antiplatelet effects. The variety of therapeutic uses seen with aspirin is believed to stem from mechanisms distinct from its COX inhibitory effect, which are beginning to be understood [5,6]. Traditionally used for primary and secondary prophylaxis against cardiovascular events, there is current interest in its protective role against colorectal cancer [7].…”

Neuroinflammation and Mitochondrial Dysfunction in the Pathogenesis of Alzheimer?s Disease: Modulation by Coriolus Versicolor (Yun-Zhi) Nutritional Mushroom

“…These proteins actively operate in detecting and controlling diverse forms of stress and neuronal injuries [7][8][9] . LXA4, a metabolic product of arachidonic acid, is considered an endogenous ''stop signal'' for inflammation, and shows potent anti-inflammatory properties in many inflammatory disorders, such as nephritis, periodontitis, arthritis, inflammatory bowel disease 10 . Microglia play an essential role in innate immunity, homeostasis, and neurotropic support in the CNS.…”