Lipschütz Acute Vulval Ulcers Associated with Primary Cytomegalovirus Infection

Abstract

A previously healthy 16-year-old girl presented with painful acute genital ulcers that appeared in the context of a primary cytomegalovirus infection. Complementary examinations ruled out both venereal disease and other usual causes of genital ulcerations, and the lesions resolved in < 2 weeks with no sequelae or later recurrences. Cytomegalovirus disease should be considered in the screening of acute vulval ulcers.

Reactive nonsexually related acute genital ulcers: Review of cases evaluated at Mayo Clinic

“…[5][6][7][8][9][10][11] Nonsexually related acute genital ulcers may arise in adolescents with other conditions such as Crohn disease or Behçet disease. We advocate the term ''reactive nonsexually related acute genital ulcers'' to refer to genital ulceration that appears to occur in response to an acute illness rather than as a manifestation of an underlying chronic systemic disease.…”

“…3,8,[10][11][12][16][17][18][19][20] Other case reports demonstrated an association between RNSRAGU and paratyphoid fever, 7 Mycoplasma pneumoniae, 21 and cytomegalovirusassociated acute mononucleosis. 9 Our group recently reported RNSRAGU arising in a patient with influenza virus infection. 4 Although much emphasis has been placed on the link between genital ulceration and EBV infection, 11 our findings indicate that a diagnosis of RNSRAGU should be suspected after any acute febrile illness in the appropriate clinical setting.…”

Acute Scrotal Ulcers in Typhoid Fever: Case Report and Literature Review

“…Rare aetiologies have also been described in the literature such as Epstein-Barr virus [8], cytomegalovirus [9], Mycoplasma pneumoniae [10], rickettsial diseases [11], tuberculosis [12], influenza [13], and cutaneous leishmaniasis [14]. …”

Ulcère de Lipschütz, un diagnostic méconnu

“…Les autres diagnostics à évoquer devant toute ulcération génitale aiguë sont la maladie de Crohn, la maladie de Behçet, ou l'aphtose génitale (aphte géant) [3]. Les auteurs suggèrent une étiologie virale de ce syndrome, avec principalement le virus d'Epstein-Barr [4,5], mais certains evoquent la participation d'autres pathogènes : CMV, toxoplasmose, paratyphoïde [6], salmonelle, grippe A [7]. De ce fait, les auteurs s'accordent à dire qu'il faut réaliser un bilan minimum comprenant la recherche des sérologies EBV, CMV et toxoplasmose principalement, et s'il existe des troubles digestifs associés, une sérologie de la salmonellose.…”