Lipskynoids A–G, New Acyclic Diterpenes from the Flowers ofCarpesium lipskyi

Abstract

Seven new acyclic diterpenes, namely lipskynoids A–G (1–7), were isolated from the flowers of Carpesium lipskyi, a traditional Tibetan herbal medicine with anti‐inflammatory and antipyretic‐analgesic effects. These new compounds were elucidated by analysis of extensive spectroscopic data including ESI‐MS, 1D, 2D NMR, and DP4+ analyses. Biological assays showed that 1–7 display significant inhibitory effects against the NO production in LPS‐induced RAW264.7 cells with its IC50 values from 9.9 to 18.47 μM, however, no cytotoxicity effect was observed of these isolates against the growth of HePG2, PC3, DU145, and A549 cells.

Characterization and phylogenetic analysis of the complete chloroplast genome of Carpesium lipskyi (Asteraceae, Inuleae)

“… 2022 ; Zhong et al. 2022 ). It was mainly distributed in Gansu, Qinghai, Sichuan, Yunnan province and growed in forest margins and hillside thickets at altitudes of 2000–3500 m (Chen and Anderberg 2011 ).…”