Liquid-based cervical cytology and microbiological analyses in women using cooper intrauterine device and levonorgestrel-releasing intrauterine system

Eleutério, José; Giraldo, Paulo César; Gonçalves, Ana Katherine; Eleutério, Renata Mírian Nunes

doi:10.1016/j.ejogrb.2020.09.051

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Both hormonal and non-hormonal contraceptives may play a role in BV occurrence. A large scale cross sectional study ( N = 16,314) found that BV is more common in women using the non-hormonal copper intrauterine device (IUD) (14.8%) than women with hormonal IUDs (9.7%) and women who are not IUD users (11.1%) ( 109 ). Another large study ( N = 2,585), as a secondary analysis, found that copper IUDs increased women's risk of BV 1.28 fold compared to other non-hormonal methods ( 110 ).…”

Section: Contraceptionmentioning

confidence: 99%

Bacterial vaginosis: a review of approaches to treatment and prevention

Abbe

Mitchell

2023

Front. Reprod. Health

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Bacterial vaginosis (BV) is a common cause of vaginitis worldwide and is associated with serious reproductive health outcomes, including increased risk of preterm birth, sexually transmitted infections, and pelvic inflammatory disease. The current and only FDA-approved treatment regimens for BV are antibiotics, such as metronidazole and clindamycin. Antibiotics provide a short-term cure for bacterial vaginosis; however, fail to provide a consistent long-term cure for many women. Fifty to eighty percent of women experience a BV recurrence within a year of completing antibiotic treatment. This may be because after antibiotic treatment, beneficial strains of Lactobacillus, such as L. crispatus, do not recolonize the vagina. In the absence of an effective long-term cure, patients, providers, and researchers are exploring different approaches to treatment and prevention, resulting in a rapid evolution of perspectives on BV pathogenesis and approaches to management. Current areas of investigation for BV management include probiotics, vaginal microbiome transplantation, pH modulation, and biofilm disruption. Behavioral modifications that may help include smoking cessation, condom use and hormonal contraception. Additional strategies considered by many people include dietary modification, non-medical vaginally applied products, choice of lubricant, and treatments from medical practices outside of allopathic medicine. This review aims to provide a comprehensive and up to date outline of the landscape of ongoing and potential treatment and prevention strategies for BV.

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Section: Contraceptionmentioning

confidence: 99%

Bacterial vaginosis: a review of approaches to treatment and prevention

Abbe

Mitchell

2023

Front. Reprod. Health

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“…A disruption in the well-balanced relationship between the genital microbiota and the host immune system maintaining homeostasis in healthy urogenital system can lead to health problems in genital tract such as persistent infection and cervical cancer [11]. Microbiota studies on women with IUD have been shown that IUD is associated with bacterial vaginosis and cervical infection [8,12,13]. Additionally, inflammatory infiltrates including leukocytes counting in cervical samples collected from women using copper IUD and control group of women not using contraception was found to be significantly more frequent in women with IUD compared to the control [12].…”

Section: Introductionmentioning

confidence: 99%

“…Microbiota studies on women with IUD have been shown that IUD is associated with bacterial vaginosis and cervical infection [8,12,13]. Additionally, inflammatory infiltrates including leukocytes counting in cervical samples collected from women using copper IUD and control group of women not using contraception was found to be significantly more frequent in women with IUD compared to the control [12]. Bacterial vaginosis is a common dysbiosis in vagina of women at reproductive age [14].…”

Section: Introductionmentioning

confidence: 99%

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Aktaş

2022

Sakarya University Journal of Science

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Intrauterine devices (IUDs), well effective long-term contraception methods used around the world, are potential reservoir for pathogens and carry risk of reproductive-tract infections such as bacterial vaginosis and vulvovaginal candidiasis. A healthy vagina is dominated by Lactobacillus involved in protecting reproductive system against pathogens. This study aims to investigate the impact of L. gasseri G10 (G10), a vaginal isolate, and its Exopolysaccharide (EPS) on adherence of Staphylococcus aureus and Candida albicans to IUD-tail. Three conditions were simulated to examine if G10 with/without EPS is capable of displacing, excluding, and competing pathogen adhesion to IUD. Inhibitory impact of EPS at various concentrations on pathogen adherence was also evaluated with co-incubation. G10 blocked by co-incubation (97%) and displacement (46%) of S. aureus adherence to IUD tail and displaced C. albicans attached to IUD with about 99%. Compared with S. aureus, the biofilm formation by C. albicans was highly susceptible to EPS. All concentrations of EPS inhibited the adherence of C. albicans (81-97%); however, no significant reductions were observed in S. aureus adherence. Moreover, G10 and EPS together reduced the adherence of both S. aureus (>99%) and C. albicans (94-98%) through all three mechanisms. This study indicates that G10 and its EPS have the ability to inhibit adhesion of S. aureus and C. albicans to IUD and potential use in intravaginal products to prevent/manage IUD associated infections in women. The results suggest development of a new way of applying IUD along with probiotic agents alone or as synbiont.

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Reproductive outcomes and reproductive tract microbiota shift in women with moderate-to-severe intrauterine adhesions following 30-day post-hysteroscopic placement of balloon stents or intrauterine contraceptive devices: A randomized controlled trial

et al. 2022

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Background: Intrauterine adhesions (IUA) develop in up to 20% of women with a history of abortion. After hysteroscopic adhesiolysis, balloon stents are usually placed for seven days to prevent recurrence. The efficacy of prolonged use (30 days) of balloon stents has not been determined. Methods: The trial was conducted from June 2019 to March 2021. Ninety-one patients who underwent hysteroscopic adhesiolysis for moderate or severe IUA were randomized to receive a 30-day placement of a balloon stent (n = 44) or an intrauterine device (IUD) (n = 47). The primary outcomes were the ongoing pregnancy and miscarriage rates assessed at 15-19 months. The secondary outcomes were the recurrence of IUA and the American Fertility Society (AFS) intrauterine adhesion scores at the first and second hysteroscopies, the diagnosis of new chronic endometritis at the second-look hysteroscopy, and the vaginal/uterine microbiome assessed using 16S rRNA sequencing. The trial was registered at Chinese Clinical Trial Registry (ChiCTR1900023306). Findings: The ongoing pregnancy rates (balloon 56¢4% versus IUD 57¢1%) and miscarriage rates (balloon 10¢3% versus IUD 22¢9%) were not significantly different between the groups. No differences in the recurrence of IUA, reduction of AFS scores, or new endometritis rates were detected. The bacterial load in the uterus and vagina increased in the IUD group but not in the balloon group. Interpretation: Balloon placement has a similar effect on ongoing pregnancy rates as intrauterine device (IUD) placement. Patients who underwent balloon placement had a lower miscarriage rate, although the difference was not significant. There were no differences in the recurrence rate of IUA, reduction of American Fertility Society scores, or rate of new chronic endometritis. The balloon stent has less effects on the uterine microbiota. Funding: National Natural Science Foundation of China (81802593).

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Liquid-based cervical cytology and microbiological analyses in women using cooper intrauterine device and levonorgestrel-releasing intrauterine system

Cited by 5 publications

References 23 publications

Bacterial vaginosis: a review of approaches to treatment and prevention

Bacterial vaginosis: a review of approaches to treatment and prevention

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Reproductive outcomes and reproductive tract microbiota shift in women with moderate-to-severe intrauterine adhesions following 30-day post-hysteroscopic placement of balloon stents or intrauterine contraceptive devices: A randomized controlled trial

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