2022
DOI: 10.1016/j.eclinm.2021.101200
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Reproductive outcomes and reproductive tract microbiota shift in women with moderate-to-severe intrauterine adhesions following 30-day post-hysteroscopic placement of balloon stents or intrauterine contraceptive devices: A randomized controlled trial

Abstract: Background: Intrauterine adhesions (IUA) develop in up to 20% of women with a history of abortion. After hysteroscopic adhesiolysis, balloon stents are usually placed for seven days to prevent recurrence. The efficacy of prolonged use (30 days) of balloon stents has not been determined. Methods: The trial was conducted from June 2019 to March 2021. Ninety-one patients who underwent hysteroscopic adhesiolysis for moderate or severe IUA were randomized to receive a 30-day placement of a balloon stent (n = 44) or… Show more

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Cited by 9 publications
(4 citation statements)
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References 33 publications
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“…Some studies investigate the effectiveness of balloon placement versus intrauterine device (IUD) for patients who aborted or had intrauterine adhesions (IUAs), as there is no significant difference in ongoing pregnancy rates between the two groups. However, the patients who underwent balloon placement had a lower miscarriage risk, but with no differences in terms of IUA recurrence, American Fertility Society (AFS) score reduction, or chronic endometritis rates, and an increase in bacterial load compared to those who used the balloon stent [99]. Though the mycobiome remains underexplored, there is no significant difference between the groups, except for an increase in Dialister, Filobasidium, and Exophiala, and a decrease in Bifidobacterium in IUA patients [100].…”
Section: Resultsmentioning
confidence: 96%
“…Some studies investigate the effectiveness of balloon placement versus intrauterine device (IUD) for patients who aborted or had intrauterine adhesions (IUAs), as there is no significant difference in ongoing pregnancy rates between the two groups. However, the patients who underwent balloon placement had a lower miscarriage risk, but with no differences in terms of IUA recurrence, American Fertility Society (AFS) score reduction, or chronic endometritis rates, and an increase in bacterial load compared to those who used the balloon stent [99]. Though the mycobiome remains underexplored, there is no significant difference between the groups, except for an increase in Dialister, Filobasidium, and Exophiala, and a decrease in Bifidobacterium in IUA patients [100].…”
Section: Resultsmentioning
confidence: 96%
“…Affecting approximately 1.5%–21.5% of women worldwide, IUA is induced by a variety of endometrial damages, including endometrial inflammation, uterine surgery, spontaneous abortion and retained products of conception. During the healing process, the contralateral uterine wall may adhere, causing partial or total occlusion of the cervical canal and uterine chamber, leading to atypical menstruation, infertility, repeated miscarriages ( Yu et al, 2008 ), or other serious gynaecological issues ( Wang et al, 2022 ). A series of strategies have been developed to prevent and treat IUA, such as microneedle patches ( Liu et al, 2019 ; Gomaa et al, 2021 ; Zhang et al, 2022 ), uterine cavity balloons ( Chen and Xie, 2016 ), transcervical resection of adhesion ( Deans and Abbott, 2010 ), and intrauterine scaffolds ( Ebrahim et al, 2018 ; Cai et al, 2019 ; Ji et al, 2020 ; Li et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…Eventually, the surgeon would return the objective lens to the cervical internal opening to guarantee the uterine cavity's shape and symmetry. And a disposable balloon stent would be placed in the uterine cavity to physically maintain the expansion of uterus, which was utilized to compress the bleeding and strengthen further recovery [16].…”
Section: Tcramentioning
confidence: 99%