Liquid Biopsy is Instrumental for 3PM Dimensional Solutions in Cancer Management

Líšková, Alena; Samec, Marek; Koklesová, Lenka; Giordano, Frank A.; Kubatka, Peter; Golubnitschaja, Olga

doi:10.3390/jcm9092749

Cited by 31 publications

(24 citation statements)

References 202 publications

(282 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the level of secondary prevention, cancer patients should undergo predictive diagnostics estimating individual metastatic potential. Recently prominent examples have been presented in the literature [ 164 , 170 , 171 ]. Various carotenoids, including β-carotene, lycopene, and retinoids and their receptors, can effectively fight against premalignant lesions in the role of secondary cancer prevention [ 172 , 173 , 174 , 175 ].…”

Section: Discussionmentioning

confidence: 99%

Carotenoids in Cancer Metastasis—Status Quo and Outlook

et al. 2020

Self Cite

View full text Add to dashboard Cite

Metastasis represents a major obstacle in cancer treatment and the leading cause of cancer-related deaths. Therefore, the identification of compounds targeting the multi-step and complex process of metastasis could improve outcomes in the management of cancer patients. Carotenoids are naturally occurring pigments with a plethora of biological activities. Carotenoids exert a potent anti-cancer capacity in various cancer models in vitro and in vivo, mediated by the modulation of signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of the epithelial–mesenchymal transition and regulatory molecules, such as matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), urokinase plasminogen activator (uPA) and its receptor (uPAR), hypoxia-inducible factor-1α (HIF-1α), and others. Moreover, carotenoids modulate the expression of genes associated with cancer progression and inflammatory processes as key mediators of the complex process involved in metastasis. Nevertheless, due to the predominantly preclinical nature of the known anti-tumor effects of carotenoids, and unclear results from certain carotenoids in specific cancer types and/or specific parts of the population, a precise analysis of the anti-cancer effects of carotenoids is essential. The identification of carotenoids as effective compounds targeting the complex process of cancer progression could improve the outcomes of advanced cancer patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Carotenoids in Cancer Metastasis—Status Quo and Outlook

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Corresponding analytical tools Application of specialized surveys [ 26 , 29 , 30 ] Broad application and comprehensive analysis of liquid biopsy [ 7 , 9 , 10 ] Individualized patient profiling and innovative screening programs focused on young populations [ 11 , 12 , 167 ] Risk assessment, predictive, and companion diagnostics [ 10 ] Multi-omics, multi-parametric analysis, and machine learning [ 171 , 172 , 173 ] …”

Section: Conclusion and Future Perspectives In The Context Of 3p mentioning

confidence: 99%

“…Liquid biopsy is a non-invasive or minimally-invasive, cost-effective, painless, precise, and real-time analysis of specific biomarkers obtained from non-solid tissues (biofluids), such as blood, urine, tears, and/or cerebrospinal fluid [ 7 , 8 , 9 , 10 ]. In this review, we discuss the applicability of liquid biopsy to the overall management of mitochondriopathies and disorders known to be associated with mitochondrial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“…In this review, we discuss the applicability of liquid biopsy to the overall management of mitochondriopathies and disorders known to be associated with mitochondrial dysfunction. Further, based on the accumulated knowledge on the pathomechanisms of mitochondrial injury, we exemplify health conditions that might be involved in the “vicious circle” of mitochondrial damage, which would allow the paradigm shift from reactive measures (treatment of clinically manifested pathologies) to the advanced concepts of predictive approach, targeted prevention, and the personalization of medical services [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mitochondriopathies as a Clue to Systemic Disorders—Analytical Tools and Mitigating Measures in Context of Predictive, Preventive, and Personalized (3P) Medicine

Líšková

Samec

Koklesová

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

The mitochondrial respiratory chain is the main site of reactive oxygen species (ROS) production in the cell. Although mitochondria possess a powerful antioxidant system, an excess of ROS cannot be completely neutralized and cumulative oxidative damage may lead to decreasing mitochondrial efficiency in energy production, as well as an increasing ROS excess, which is known to cause a critical imbalance in antioxidant/oxidant mechanisms and a “vicious circle” in mitochondrial injury. Due to insufficient energy production, chronic exposure to ROS overproduction consequently leads to the oxidative damage of life-important biomolecules, including nucleic acids, proteins, lipids, and amino acids, among others. Different forms of mitochondrial dysfunction (mitochondriopathies) may affect the brain, heart, peripheral nervous and endocrine systems, eyes, ears, gut, and kidney, among other organs. Consequently, mitochondriopathies have been proposed as an attractive diagnostic target to be investigated in any patient with unexplained progressive multisystem disorder. This review article highlights the pathomechanisms of mitochondriopathies, details advanced analytical tools, and suggests predictive approaches, targeted prevention and personalization of medical services as instrumental for the overall management of mitochondriopathy-related cascading pathologies.

show abstract

“…Circulating tumor cells (CTCs) are all kinds of tumor cells existing in peripheral blood. 4 Tumor cells invade the blood and lymphatic system, form CTCs, and are transported to the distal tissue. 5 The early detection of CTCs in the blood has significance in making prognostic judgments, evaluation of the curative effect, and individualized treatment.…”

Section: Introductionmentioning

confidence: 99%