Liquid chromatographic determination of ceterizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations

Nagaralli, B. S.; Seetharamappa, J.; Gowda, Babu Giriya; Melwanki, Mahaveer B.

doi:10.1016/j.jchromb.2003.08.048

Cited by 46 publications

(18 citation statements)

References 9 publications

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“…The limit of quantitation for cetirizine was proved to be 10 ng/mL, with precision 10.2 and 9.6% and accuracy 97 and 94% for CE and HPLC, respectively (Table 2). These methods were sufficiently sensitive, with a comparable quantification limit (Macek et al, 1999;Kim et al, 2005) or lower than for the earlier published HPLC methods with spectrophotometric detection (Choi et al, 2000a;Zaater et al, 2000;Moncrieff, 1992;Nagaralli et al, 2003).…”

Section: Limit Of Detection and Quantitationmentioning

confidence: 82%

“…A high-performance liquid chromatography (HPLC) with ultraviolet detection (UV) is the most widely used technique (Macek et al, 1999;Choi et al, 2000a, b;Kim et al, 2005;Zaater et al, 2000;Moncrieff, 1992;Jelinska et al, 2000Jelinska et al, , 2001Paw et al, 2002;Arayne et al, 2005;Bajerski et al, 2005;El Walily et al, 1998;Jaber et al, 2004;Nagaralli et al, 2003;Likar et al, 2005;Rosseel and Lefebvre, 1991) or liquid chromatography with spectrometric detection (LC-MS/MS) (Gergov et al, 2001;Gupta et al, 2005;de Jager et al, 2002;Rudaz et al, 2003;Song et al, 2005;Tan et al, 2006). Previously published methods included also gas chromatography (GC) (Baltes et al, 1988), high-performance thin-layer chromatography (HPTLC) (Makhija and Vavia, 2001;Pandya et al, 1996), electrooxidation (Güngör, 2004), spectrophotometric (El Walily et al, 1998;Mahgoub et al, 2003;Gowda et al, 2001;Basavaiah and Charan, 2002;Basavaiah et al, 1999;Gazy et al, 2002), titrimetric technique (Basavaiah and Charan, 2002) for cetirizine determination and assay based on cetirizine-tetraphenylborate ion-pair analysis (Shoukry et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…A literature survey reveals that the majority of the papers describe the measurement in pharmaceutical formulations (Jelinska et al, 2000(Jelinska et al, , 2001Paw et al, 2002;Arayne et al, 2005;Bajerski et al, 2005;El Walily et al, 1998;Jaber et al, 2004;Nagaralli et al, 2003;Likar et al, 2005;Rudaz et al, 2003;Makhija et al, 2001;Güngör, 2004;Mahgoub et al, 2003;Gowda et al, 2001;Basavaiah and Charan, 2002;Basavaiah et al, 1999;Gazy et al, 2002;Shoukry et al, 1999). There are only a few reports on the cetirizine analysis in human (Macek et al, 1999;Kim et al, 2005;Nagaralli et al, 2003;de Jager et al, 2002;Song et al, 2005;Tan et al, 2006;Baltes et al, 1988;Pandya et al, 1996) or animal plasma samples (Choi et al, 2000a;Gupta et al, 2005), which have been based on HPLC following some form of liquid-liquid extraction (LLE) (Macek et al, 1999;Choi et al, 2000a;Kim et al, 2005;Nagaralli et al, 2003;Gupta et al, 2005;de Jager et al, 2002;Tan et al, 2006) or solidphase extraction (SPE) (Song et al, 2005). Some methods have been described for quantitation of cetirizine also in serum (Zaater et al, 2000;Moncrieff, 1992), blood …”

Section: Introductionmentioning

confidence: 99%

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Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Kowalski

Plenis

2007

Biomedical Chromatography

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Two methods, capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC), for analysis of cetirizine dihydrochloride in small sample volumes of human plasma were compared. The CE and HPLC assays were developed and validated by analyzing a series of plasma samples containing cetirizine dihydrochloride in different concentrations using these two methods. The extraction procedure is simple and no complicated purification steps or derivatization are required. The analysis time in the HPLC method was shorter than that in the CE method, but solvent consumption was considerably lower in the CE method. The calibration curve was linear to at least 10-1000 ng/mL both for CE and HPLC with r(2) = 0.9993 and r(2) = 0.9994, respectively. The detection limits for cetirizine dihydrochloride were 3 and 5 ng/mL with CE and HPLC (a UV detector was applied in the both cases), respectively. Both methods were selective, robust and specific, allowing reliable quantification of cetirizine dihydrochloride, and could be useful for clinical and biomedical investigations.

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Section: Limit Of Detection and Quantitationmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Kowalski

Plenis

2007

Biomedical Chromatography

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“…Several HPLC methods have been reported in literature for the determination of PCA with CTZ [4,5], PCA with PSU [6][7][8][9], and CTZ with PSU [10][11][12]. The three drugs were also determined in the presence of their degradation products [13].…”

Section: Introductionmentioning

confidence: 99%

Chemometrically optimized micellar liquid chromatographic method for the simultaneous determination of cetirizine dihydrochloride in its combined dosage forms. Application to biological fluids and pharmacokinetic studies

El-Din¹,

Ibrahim²,

Eid³

et al. 2013

Acta Chromatographica

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Abstract. An accurate, simple, sensitive, and selective micellar liquid chromatographic method has been developed for the simultaneous determination of cetirizine dihydrochloride in two of its combined pharmaceutical preparations with psudoephedrine hydrochloride and/or paracetamol. The chemometrics approach was applied for the optimization of separation of the studied drugs to optimize their separation; the effect of six experimental parameters on retention was investigated by means of multivariate analysis. Separation was conducted using an ODS C18 (150 × 4.6 mm id) stainless steel column at ambient temperature with UV-detection at 250 nm. A mobile phase composed of 0.135 M sodium dodecyl sulphate, 11% 1-propanol, 0.3% tri-ethylamine in 0.02 M phosphoric acid, and adjusted to pH 3.3 has been used at a flow rate of 1 mL/min. Regression models were characterized by both descriptive and predictive ability (R 2 ≥ 98.8% and R 2 cv ≥ 94.5%) and allowed the chromatographic separation of the drugs with a good resolution and a total analysis time within 6 min.The calibration curves were rectilinear over the concentration ranges of 0.05-1.0, 0.07-4.0, and 1.0-10.0 μg/mL for cetirizine dihydrochloride, psudoephedrine hydrochloride, and paracetamol respectively; with detection limits of 0.01, 0.05, and 0.08 μg/mL, and quantification limits of 0.04, 0.09, and 1.02 μg/mL, respectively. The results obtained were in good agreement with those obtained by the comparison method. Furthermore, the method was applied for the determination of the drugs in spiked human plasma and used to reveal the pharmacokinetic characters in a healthy volunteer treated with oral administration of the studied two combined dosage forms of cetirizine.

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“…Different analytical methods for determination of this antihistaminic in biological fluids (urine, plasma, serum) have been reported and include HPLC, [6][7][8][9] HPLC-MS, [10][11][12] CG, 13 HPTLC, 14 and TLC. 15 In pharmaceutical dosage forms (tablets, compounded capsules, solutions) this drug was analyzed isolated by HPLC, [16][17][18][19] HPLC-MS, 20 and spectrophotometry, 4,16,21,22 or combined with multicomponent dosage forms by spectrophotometry, 22 HPTLC, 23 and HPLC.…”

Section: Introductionmentioning

confidence: 99%

Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

Bajerski¹,

Sangoi²,

Barth³

et al. 2010

Quím. Nova

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Recebido em 13/2/09; aceito em 21/7/09; publicado na web em 25/11/09 A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L -1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques.

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Liquid chromatographic determination of ceterizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations

Cited by 46 publications

References 9 publications

Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Chemometrically optimized micellar liquid chromatographic method for the simultaneous determination of cetirizine dihydrochloride in its combined dosage forms. Application to biological fluids and pharmacokinetic studies

Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

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