Liquid chromatographic methods validation for pharmaceutical products

Wilson, Terry D.

doi:10.1016/0731-7085(90)80066-x

Cited by 27 publications

(2 citation statements)

References 88 publications

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“…The analysis of plasma concentration of curcumin and quercetin was validated using the standard procedure (Wilson, 1990). The calibration curves of curcumin and quercetin showed good linearity over the tested concentrations.…”

Section: Resultsmentioning

confidence: 99%

The Increased Cellular Uptake and Biliary Excretion of Curcumin by Quercetin: A Possible Role of Albumin Binding Interaction

Kim¹,

Lee²,

Lee³

et al. 2012

Drug Metabolism and Disposition

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ABSTRACT:Curcumin and quercetin are natural compounds with a wide spectrum of activities, including antioxidant and anticancer activities. In this study, the combined effect of the two compounds was investigated, with special emphasis on the pharmacokinetics of curcumin by the quercetin-induced changes in the albumin binding of curcumin. We evaluated the effect of quercetin on the binding of curcumin to albumin and on the uptake of curcumin into the cells of the human colon carcinoma cell line WiDr. In addition, we also investigated changes in the in vivo pharmacokinetics of curcumin and curcumin sulfate (the major metabolite of curcumin) coadministered with quercetin. We found that quercetin inhibited the binding of curcumin to albumin and increased the uptake of curcumin into WiDr cells, the human colon carcinoma cell. The quercetininduced increased uptake (1.6-fold) of curcumin into WiDr cells was also confirmed by an ex vivo study. The in vivo pharmacokinetics of curcumin showed obvious changes when it was coadministered with quercetin, with the significantly lower plasma concentration and greater biliary excretion of curcumin and curcumin sulfate. The present study suggests that quercetin could enhance the cellular uptake of curcumin and modulate in vivo pharmacokinetics of curcumin, and it could be related to albumin-binding interaction.

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Section: Resultsmentioning

confidence: 99%

The Increased Cellular Uptake and Biliary Excretion of Curcumin by Quercetin: A Possible Role of Albumin Binding Interaction

Kim¹,

Lee²,

Lee³

et al. 2012

Drug Metabolism and Disposition

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show abstract

“…The literature contains diverse approaches to performing method validation (Crowther, 2001;Wilson, 1990;Clarke, 1994;Bressolle et al, 1996;Carr & Wahlich 1990;Green, 1996;Trullols et al, 2004;Ermer, 2001;Daraghmeh, 2001;Badea et al, 2004;Mendez et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Application of Best Practice in Analytical Method Validation

Shabir

Lough

Arain

et al. 2007

Journal of Liquid Chromatography & Related Technologies

121

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Characterization of pharmaceutical drugs by a modified nonaqueous capillary electrophoresis – mass spectrometry method

et al. 2003

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A simple method for the separation and characterization of a group of nine basic compounds, comprising seven tricyclic antidepressant and two bronchodilator drugs, by nonaqueous capillary electrophoresis (NACE) employing ultraviolet and mass spectrometry detection is described. After optimization of the electrophoresis separation conditions, including the compositions of the electrolyte and the organic solvent, a reliable separation of all nine basic analytes was achieved in 80 mM ammonium formate dissolved in a methanol-acetonitrite (80:20 v/v) mixture, having an apparent pH of 8.7. The volatile nonaqueous electrolyte system used with a normal electroosmotic flow polarity also provided an optimal separation condition for the characterization of the analytes by mass spectrometry. When results were compared with reversed-phase gradient and isocratic high-performance liquid chromatography (HPLC) methods, the NACE method provided greater efficiency, achieving baseline resolution for all nine basic compounds in less than 30 min. The NACE method is suitable for use as a routine procedure for the rapid separation and characterization of basic compounds and is a viable alternative to HPLC for the separation of a wide range of pharmaceutical drugs.

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Liquid chromatographic methods validation for pharmaceutical products

Cited by 27 publications

References 88 publications

The Increased Cellular Uptake and Biliary Excretion of Curcumin by Quercetin: A Possible Role of Albumin Binding Interaction

The Increased Cellular Uptake and Biliary Excretion of Curcumin by Quercetin: A Possible Role of Albumin Binding Interaction

Evaluation and Application of Best Practice in Analytical Method Validation

Characterization of pharmaceutical drugs by a modified nonaqueous capillary electrophoresis – mass spectrometry method

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