Liquid chromatographic–tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma

Yan, Tingting; Li, Hao; Deng, Lili; Guo, Yanglong; Yu, Weisong; Fawcett, J. Paul; Zhang, Dan; Chen, Yimin; Gu, Jingkai

doi:10.1016/j.jpba.2008.08.021

Cited by 44 publications

(23 citation statements)

References 8 publications

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“…Individually, TELM is estimated by LC-MS (3), LC-tendem MS (4,5). The majority of methods reported are liquid chromatography in which TELM was estimated simultaneously with hydrochlorthiazide (6,7,8), with ramipril (9, 10), with AmLodipine (11). Some three components are also reported along with TELM such as, Column Switching LC with fluorescence detection (12).…”

Section: Preparation Of Laboratory Mixturementioning

confidence: 99%

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Charde¹,

Gupta²,

Chakole³

2012

Int J Pharmceut Chem

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A simple, rapid, precise, sensitive and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for determination of Telmisartan (TELM) in tablet dosage form was developed and validated. Chromatographic separation was achieved on a 250 × 4.6 mm, 5µ, Waters symmetry column in gradient mode, with mobile phase consisting of a mixture of solution (10 mM potassium dihydrogen phosphate, pH 3.5 ± 0.01): acetonitrile (64:40) was used. The quantitation performed at flow rate of 1.0 mL/min at 230 nm and run time was 12 min. The analytical method was validated as per ICH guideline for linearity, accuracy, precision, specificity, limit of detection, limit of quantification, robustness and stability and method can be extended to the analysis of TELM in tablet formulations. The relative standard deviation values for precision was less than 2%, and % recovery was greater than 98% for TELM. The drug undergoes oxidative degradation, thermal degradation and in alkali medium.

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Section: Preparation Of Laboratory Mixturementioning

confidence: 99%

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Charde¹,

Gupta²,

Chakole³

2012

Int J Pharmceut Chem

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show abstract

“…Several HPLC-UV [4][5][6][7], LC-MS/MS [8][9][10][11][12][13][14][15][16][17] and HPLC-Fluorescence [18][19][20][21][22][23][24][25][26][27][28][29][30][31] methods have been reported for quantification of telmisartan in biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a High Performance Liquid Chromatography Method for Determination of Telmisartan in Rabbit Plasma and its Application to a Pharmacokinetic Study

Virkar¹,

Pingale²

2012

J Anal Bioanal Techniques

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A simple and sensitive High-Performance Liquid Chromatography (HPLC) method with fluorescence detection for quantitation of telmisartan in rabbit plasma was developed and validated. Separation of telmisartan from plasma components was achieved on a Chromolith RP18e column (100 x 4.6 mm 5 µ). Losartan was used as an internal standard. A mobile phase consisting of 50 mM sodium phosphate buffer and acetonitrile in the volume ratio of 65:35 v/v was delivered at a flow rate of 3.5 mL/min.A simple and rapid sample preparation involved solid phase extraction using Varian Bond Elute C-18 cartridge. The linearity range of the proposed method was 4 to 375 ng/mL. The intra-day and inter-day coefficients of variation obtained for telmisartan were less than 4.90% and relative error was less than 9.08%. The overall recoveries for telmisartan and losartan were 101.7% and 100.0%, respectively. This validated method was used successfully for analysis of plasma samples from a pharmacokinetic study.

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“…Individually, Telmisartan is estimated by LC-MS ( 3 ), LC-tendem MS ( 4,5 ). The majority of methods reported are liquid chromatography in which Telmisartan was estimated simultaneously with hydrochlorothiazide ( 6,7,8 ), with ramipril ( 9, 10 ), with Amlodipine ( 11 ). Some triple combinations are also reported along with telmisartan such as, Column Switching LC with fluorescence detection ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Gupta¹,

Charde²,

Charde³

2012

Int J of Adv in Phar Ana

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A simple, rapid, precise, rapid, sensitive and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for determination of Telmisartan in tablet dosage form was developed and validated. Chromatographic separation was achieved on a 250 × 4.6 mm, 5µ, Waters symmetry column in gradient mode, with mobile phase consisting of a mixture of solution (10 mM potassium dihydrogen phosphate, pH 3.5 ± 0.01): acetonitrile (64:40) was used. The quantitation performed at flow rate of 1.0 ml/min at 230 nm and run time was 12 min. The analytical method was validated as per ICH guideline for linearity, accuracy, precision, specificity, limit of detection, limit of quantification, robustness and stability and method can be extended to the analysis of Telmisartan in tablet formulations. The relative standard deviation values for precision was less than 2%, and % recovery was greater than 98% for Telmisartan. The drug undergoes oxidative degradation, thermal degradation and in alkali medium.

show abstract

Liquid chromatographic–tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma

Cited by 44 publications

References 8 publications

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Development and Validation of a High Performance Liquid Chromatography Method for Determination of Telmisartan in Rabbit Plasma and its Application to a Pharmacokinetic Study

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

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