Liquid chromatography coupled with multi-channel electrochemical detection for the determination of daidzin in rat blood sampled by an automated blood sampling system

Tian, Feifei; Zhang, Yongxin; Long, Hong; Cregor, Meloney; Xie, Fang; Kissinger, Candice B.; Kissinger, Peter T.

doi:10.1016/s1570-0232(02)00087-9

Cited by 14 publications

(8 citation statements)

References 27 publications

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“…There are few reports on the separation of drugs in plasma extracts using columns of 1 mm i.d. [16][17][18]. None of them describe better results regarding sample volumes, detection limits or on-column sensitivities than the reports on 2 and 3 mm i.d.…”

Section: Introductionmentioning

confidence: 90%

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Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma

Oudhoff

Sangster

Thomas

et al. 2006

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 90%

“…Water was deionised with a water purification system (Elgastat Maxima, Elga, High Wycombe, UK). 18 (2) packing material. The isocratic mobile phase was a mixture of methanol-water (7:3, v/v) with 0.2% (v/v) formic acid.…”

Section: Chemicalsmentioning

confidence: 99%

Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma

Oudhoff

Sangster

Thomas

et al. 2006

Journal of Chromatography B

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“…The Culex automated blood sampler provides a way for blood withdrawal at preprogrammed intervals, which is more accurate and less labor intensive. 27 Six rats in the PK group were implanted with a jugular vein catheter under an isoflurane anesthesia. After the surgery, rats were allowed to recover for 96 hours with free access to food and water.…”

Section: Chemicalsmentioning

confidence: 99%

The Evaluation of Radiolabeled Artesunate on Tissue Distribution in Rats and Protein Binding in Humans

Li¹,

Xie²,

Haeberle³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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The present study reports the tissue distribution, pharmacokinetics, mass balance, and elimination of [(14)C] artesunate (AS) following single intravenous administration in rats. Protein binding was performed with rat and human plasma. Radioactivity and drug levels in blood, plasma, tissues, urine, and feces up to 192 hours were collected and measured. The mean terminal half-life of plasma (76 h) and blood (105 h) radioactivity was prolonged compared with that of unchanged AS (0.43 h) and dihydroartemisinin (0.75 h), an active metabolite of AS. Drug was widely distributed after 1 hour in select tissues. After 24 hours, the radioactivity rapidly declined in all tissues except spleen until 96 hours. Only 1% of total radioactivity was detected in brain tissue. AS revealed a higher binding capacity with human and rat plasma proteins (73-81%). The radioactivity in whole blood was higher (two to fourfold) than that in plasma throughout the period of the treatment, suggesting that AS binding to RBCs may relate to its powerful antimalarial activity.

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“…S.-C. Wang et al ORIGINAL RESEARCH the use of automated blood sampling systems has been successfully demonstrated by Kissinger's group Tian et al, 2001;Zhu et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

An automated blood sampling system to measure lovastatin level in plasma and faeces

Wang

Ho²,

Yen³

et al. 2006

Biomedical Chromatography

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The aim of this study was to develop an automated sampling method to measure lovastatin in a conscious and freely moving rat. The blood samples were collected by means of the automated blood sampling system DR-II and the faecal samples were collected using a metabolic cage. The concentration of lovastatin was determined by a reversed-phase liquid chromatographic system with a UV absorbance detector. The mobile phase contained acetonitrile and 10 mm NaH2PO4 in the proportions 60:40 (v/v) with a flow-rate of 1 mL/min. The calibration curve was linear in concentration ranges of 0.05-100 and 0.1-100 microg/mL for lovastatin in blood and faecal samples, respectively. Following pharmacokinetic analysis, we identified that the maximum plasma concentration was around 1.18 +/- 0.08 microg/mL at concentration peak time 120 min and almost 78% of loading dose was accumulated in the faeces within 48 h after lovastatin administration (500 mg/kg, p.o.).

show abstract

Liquid chromatography coupled with multi-channel electrochemical detection for the determination of daidzin in rat blood sampled by an automated blood sampling system

Cited by 14 publications

References 27 publications

Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma

Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma

The Evaluation of Radiolabeled Artesunate on Tissue Distribution in Rats and Protein Binding in Humans

An automated blood sampling system to measure lovastatin level in plasma and faeces

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