Liquid chromatography–mass spectrometry analysis of macranthoidin B, macranthoidin A, dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation

Simultaneous determination of active xanthone glycosides, timosaponins and alkaloids in rat plasma after oral administration of Zi-Shen Pill extract for the pharmacokinetic study by liquid chromatography–tandem mass spectrometry

“…Notably, distinct double-peaks were observed in both individual and mean plasma concentration-time curves of all these timosaponins. Previous pharmacokinetic studies [23,24] also revealed the double-peak phenomenon in several other saponins. It is well known that drug absorption is a very complex process that manifests itself through potential interaction with a host of physicochemical and physiological variables.…”

Turbulent-flow chromatography coupled on-line to fast high-performance liquid chromatography and mass spectrometry for simultaneous determination of verticine, verticinone and isoverticine in rat plasma

“…There are, at present, many analytical methods used for pharmacokinetic study of bioactive compounds in TCMs, such as LC/UV [3], immunoassay [4], LC/ELSD [5], LC/MS [6,7] and LC/MS/MS [8]. Among these methods, LC/UV, immunoassay and LC/ELSD methods show lack of sensitivity, low selectivity and tend to suffer from cross-interference.…”

Simultaneous determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and icariin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry

“…Some studies indicated that H. epimedii, in combination with other herbal drugs, has been used clinically as oriental traditional medicines against stroke, Alzheimer's disease or vascular dementia [3,4]. Owing to limitations of single chemistry, combinatorial multi-component therapies (CMCT) of medicines are accepted for their more specific and fewer side effects [5]. Chinese herbal medicines (CHMs) consisting of multi-components are abound naturally occurring resources for CMCT.…”