Liquid chromatography on-chip: progression towards a μ-total analysis system

McEnery, Mairead; Tan, Aimin; Alderman, J.; Patterson, J. C.; O’Mathuna, S.C.; Glennon, Jeremy D.

doi:10.1039/a907856h

Cited by 56 publications

(31 citation statements)

References 10 publications

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“…In principle, the flow analytical manifold (the layout of the flow analytical technique) is simplified if a highly selective electrochemical detection mode is applied. Flow analytical techniques involving in-flow separation (e.g., LC [6][7][8], capillary electrophoresis [9,10], microdialysis [11], etc. ), chemical transformation, and/or preconcentration [12] remain, however, important because of the limitations of electrochemical detection and because there is only a limited number of selective detectors of sufficient sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical detection in liquid flow analytical techniques: Characterization and classification (IUPAC Technical Report)

Tóth¹,

Štulı́k²,

Kutner³

et al. 2004

Pure and Applied Chemistry

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Liquid flow analytical techniques are classified, and definitions are provided of flow-injection analysis, segmented flow analysis, flow titration, continuous monitoring, liquid chromatography, and capillary electrophoresis. Electrochemical detection and flow through detection cells are characterized with respect to the surface and bulk detection. The detector performance is discussed in terms of its principal analytical parameters, such as detection limit and dynamic concentration range, as well as its dynamic characteristics, such as the response time, sampling frequency, transport lag, and long-term stability. Moreover, different detection modes are critically evaluated, including both potentiostatic and galvano-static techniques. Factors influencing sensitivity and detection limit, which include electronic and hydrodynamic approach, are also discussed. Different detector designs are critically reviewed, and the special features of electrochemical detectors for flow analytical techniques are emphasized.

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Section: Introductionmentioning

confidence: 99%

Electrochemical detection in liquid flow analytical techniques: Characterization and classification (IUPAC Technical Report)

Tóth¹,

Štulı́k²,

Kutner³

et al. 2004

Pure and Applied Chemistry

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“…Many research groups are developing on-chip chromatographic 15 and spectroscopic methods 16 that will be integrated with this approach in future work to enable microscale synthesis and characterization of well-defined polymeric materials in gradient libraries. We envision this technique will enable more comprehensive studies than are currently possible, spanning vast areas of molecular variable space.…”

mentioning

confidence: 99%

A New Synthetic Method for Controlled Polymerization Using a Microfluidic System

et al. 2004

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Polymer materials applications increasingly show sensitivity to single-chain variables such as molecular mass and copolymer composition. [1][2][3] While many parallel synthesis methods developed by the pharmaceutical and life science communities are being applied to polymer synthesis, 4,5 there remains a need to construct polymeric material "libraries" that explore a wide range of polymer structures with accuracy, flexibility, and rapid, often precise, changes.Recent development of various analytical methods, such as micrototal analytical systems (µTAS), 6,7 have also increased the

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“…(3) showed typical values of around 3. For the sake of comparison, Manz et al [6] reported a retention factor of 3.3 for their open tubular LC column on chip, while McEnery [12] showed performances below presented values.…”

Section: Chromatographic Separationsmentioning

confidence: 99%

“…In addition, electrophoretic techniques find abundant application in biomolecular analysis, a tremendous market driver at the present time. On the other hand, chip-based pressure-driven liquid chromatographic (LC) systems have been slow to find extensive interest, and have been pioneered by a handful of workers [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. This is mainly due to lack of ease of flow control as is the case with electrokinetically driven devices where mechanical pumps and * Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

“…In this design, an injection plug of fixed volume is contained in the main channel segment between the two side branches. The design requires use of syringe pumps or a standard HPLC injection valve [6,12,15]. However, it is difficult to assure repeatability using this technique, as the confining segment is easily overflowed, and the extremely low flow rates for sample loading are difficult to obtain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Continuous sampling and analysis by on-chip liquid/solid chromatography

Schlund

Gilbert²,

Schnydrig

et al. 2007

Sensors and Actuators B: Chemical

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This paper describes a lab-on-a-chip device for continuous liquid/solid chromatography measurements. Chromatographic separations of phenolic test solutions as well as of vitamins are illustrating the ability and versatility of the system. The dependence of the peak height and width with respect to the injected plug and the saturation limits of the microchip column have been investigated and good correlation to the theoretical predictions have been observed.The focus of the system design is on simplification of both fabrication complexity and application. To this end, large bore flow-through fluid introduction channels have been integrated onto the chip to allow aliquoting from meso-scale flows of sample (up to tens of milliliters per minute). Repeatable plug injections and reproducible chromatographic separations were achieved in an open-tubular on-chip microcolumn with C 8 stationary phase coating. The entire system allows for a rapid cycle time for multiple analyses, exchange of analyte and mobile phase in less than a minute, and complete cleaning cycles within a few seconds only. This makes it a suitable candidate for on-line process analysis applications.

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Liquid chromatography on-chip: progression towards a μ-total analysis system

Cited by 56 publications

References 10 publications

Electrochemical detection in liquid flow analytical techniques: Characterization and classification (IUPAC Technical Report)

Electrochemical detection in liquid flow analytical techniques: Characterization and classification (IUPAC Technical Report)

A New Synthetic Method for Controlled Polymerization Using a Microfluidic System

Continuous sampling and analysis by on-chip liquid/solid chromatography

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