Liquid Crystalline Polymers: Opportunities to Shape Neural Interfaces

Rihani, Rashed; Tasnim, Nishat; Javed, Mahjabeen; Usoro, Joshua O.; D'Souza, Tania; Ware, Taylor H.; Pancrazio, Joseph J.

doi:10.1111/ner.13364

Cited by 12 publications

(19 citation statements)

References 86 publications

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“…Neural interfaces have been playing a significant role in the field of neural implants [101] such as researchers have implemented robotic limbs [102] speech synthesizer [103] human neuroprosthetic control of human cursor [104][105][106] auditory prosthesis, retinal prosthesis etc. Neural interfaces allow for the recording and activation of neural tissue, allowing the peripheral and central nervous systems to be successfully connected to the outside world [107]. All of these strategies, however, have a number of flaws.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, scientists are considering inventing new materials to preserve electronics over lengthy periods of time. According to a recent study, liquid crystal polymers exhibit a molecular arrangement close to that of a solid while maintaining the fluidity of liquid, which helped them improve several unique qualities such as low water permeability, chemical inertness, and mechanical durability [107]. A recent on liquid crystal elastomers, a subclass of LCPs, has shown that it is possible to construct devices with features that deploy away from a central insertion point to link with tissue volume while minimizing tissue injury [107].…”

Section: Discussionmentioning

confidence: 99%

“…According to a recent study, liquid crystal polymers exhibit a molecular arrangement close to that of a solid while maintaining the fluidity of liquid, which helped them improve several unique qualities such as low water permeability, chemical inertness, and mechanical durability [107]. A recent on liquid crystal elastomers, a subclass of LCPs, has shown that it is possible to construct devices with features that deploy away from a central insertion point to link with tissue volume while minimizing tissue injury [107]. There are limitations in electrical stimulation too, researchers are reconsidering using optogenetic tools as a stimulation method to bypass these all limitations [112].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Neural Implants: A Review Of Current Trends And Future Perspectives

Mim¹,

Haque²,

Promon³

2022

Preprint

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Recent progress in microfabrication technique allowed the rapid development of neural implants. They are getting categorized as effective tools for clinical practice, especially to treat traumatic and neurodegenerative disorders. Microelectrode arrays already have been used in numerous neural interface devices. Basically, almost all neural implants have been developed based on BCI (Brain Computer Interface) system. When BCI system falls under invasive technique, it is referred as BMI or Brain Machine Interface. BMIs hold promises for neurorehabilitation of motor and sensory function, cognitive state evaluation and treatment of neurological chaos. A directed overview of the field of neural implants is discussed in this article. The aim of this review is to give a brief introduction of neural prosthetics as well as their exciting applications in treating neurological disorders and a deep discussion on their functionality are mentioned. BCI system and their different types, their functionality, their pros and cons, how other neural implants developed, and their present status have been covered. Different possibilities and possible future of deep brain stimulation (DBS), Neuralink, motor and sensory neural prosthetics are further discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neural Implants: A Review Of Current Trends And Future Perspectives

Mim¹,

Haque²,

Promon³

2022

Preprint

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“…In an effort to address the mechanical mismatch between implantable bioelectronic devices and neural tissues, the development of soft and flexible materials is becoming an important niche of neural interface research. [17] In particular, elastomeric or shape memory polymers, capable of dampening relative micromotion, offer a viable strategy in reducing the mechanical stresses generated in peri-implant tissues. [17][18][19] For example, recent studies into neuroelectrode fabrication have shown that soft electrode formulations reduce gliosis "in vivo" [4,6,17] and enhance tissue integration, improving change transfer capability and promoting chronic electrode functionality.…”

Section: Current Approaches and Challenges To Neural Interface Designmentioning

confidence: 99%

Understanding the Mechanobiology of Gliosis May Be the Key to Unlocking Sustained Chronic Performance of Bioelectronic Neural Interfaces

Vallejo-Giraldo

Krukiewicz

Biggs

2021

Advanced NanoBiomed Research

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In an effort to develop the next generation of neural implants, current research has focused on solving the challenges associated with the foreign body reaction and promoting long‐term device performance in vivo. Although the cutting edge of research in this field appears to be moving away from traditional metallic and semiconductor materials, the complex tissue dynamics which occur at the electrode–neural interface following device implantation are yet to be resolved. In particular, understanding the molecular processes of gliosis and the onset and persistence of scar formation is key in developing stable and specific neural recording/stimulation devices. Critically, it is recognized that neural device implantation leads to a significant disruption of tissue integrity at the peri‐electrode site. Accordingly, an in‐depth understanding of mechanotransduction in neuronal cell populations at the peri‐implant region is required to better inform neural interface design. This perspective highlights the need for a comprehensive mechanobiological understanding of gliosis to enhance the development of neural implants with improved chronic functionality.

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“…For notable examples, Kevlar—lyotropic LC aromatic polyamide—and Vectra—thermotropic aromatic LC polyester—are the basis of lightweight, high-strength materials for a number of civilian and military applications, including their important contributions in body armor. Side-chain LC polymers are known as functional polymers for non-linear optical properties and data storage capabilities [ 2 , 3 ]. Additionally, ionic liquid crystals (ILCs) that form columnar, smectic and bi-continuous cubic phases can provide well-organized 1D, 2D and 3D channels capable of transporting ions and electrons [ 4 , 5 ].…”

mentioning

confidence: 99%