Liquid Marbles: A Promising and Versatile Platform for Miniaturized Chemical Reactions

Xin, Zhuo; Skrydstrup, Troels

doi:10.1002/anie.201905204

Cited by 26 publications

(19 citation statements)

References 18 publications

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“…In a previous study, the influence of particle diameter on F cap was estimated as: F cap = 288 −1 π ρ w 2 g 2.5 D p 6 γ w b −1 . [23] For a particle size below 10 µm, F cap was estimated as: [32] F cap = 1.5πξ 2 γ w b −5 (D p sinθ p ) 4 , where ξ is the undulation amplitude of the menisci between particles. From this model, F cap ∝ b −5 (D p sinθ p ) 4 , and we obtain the maximum F inter-p when θ p = 90°.…”

Section: Increasing the Robustness Of Liquid Marblesmentioning

confidence: 99%

“…Liquid marbles behave like a soft solid and can carry an inner liquid without undesired adhesion loss. [1,2] By replacing the inner liquid with bio(medical) species, [3] chemicals, [4] or adhesives, [5] liquid marbles can be used in numerous applications including microreactors, [4,6] biomedical platforms, [7,8] sensors, [9,10] cargo transportation, [11,12] and fluidic devices. [13,14] However, liquid marbles are generally fragile and break under pressure or impact, which limits their practical use.…”

Section: Introductionmentioning

confidence: 99%

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How Liquid Marbles Break Down: Direct Evidence for Two Breakage Scenarios

Tenjimbayashi

Fujii

2021

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Liquid marbles are nonsticking droplets wrapped with hydrophobic nano‐ to micrometer particles and are expected to be useful for various applications, especially in industrial and biomedical fields. However, the practical use of liquid marbles is limited by their fragility. In this study, the dynamics of particle monolayer–stabilized liquid marble breakage upon impacting a solid surface are monitored in situ by high‐speed interfacial microscopy. The experiments show that the breakage of liquid marbles can be induced by either i) cracking or ii) water penetration depending on the impact energy. The applicable scenario is determined by whether a jamming transition of the wrapping particles occurs during impact. The breakage mechanisms provide insights on how to improve the robustness of liquid marbles in accordance with these scenarios.

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Section: Increasing the Robustness Of Liquid Marblesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

How Liquid Marbles Break Down: Direct Evidence for Two Breakage Scenarios

Tenjimbayashi

Fujii

2021

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“…To date, most studies on the applications of liquid marbles as microreactors were carried out by premixing and encapsulating all the reagents in a single liquid marble, owing to the convenience of this method [29]. Nevertheless, performing reactions in a system with multiple liquid marbles has gained more interest.…”

Section: Manipulation For Coalescencementioning

confidence: 99%

Liquid Marbles as Miniature Reactors for Chemical and Biological Applications

et al. 2020

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The need for miniaturised reaction systems has led to the development of various microreactor platforms, such as droplet-based microreactors. However, these microreactors possess inherent drawbacks, such as rapid evaporation and difficult handling, that limit their use in practical applications. Liquid marbles are droplets covered with hydrophobic particles and are a potential platform that can overcome the weaknesses of bare droplets. The coating particles completely isolate the interior liquids from the surrounding environment, thus conveniently encapsulating the reactions. Great efforts have been made over the past decade to demonstrate the feasibility of liquid marble-based microreactors for chemical and biological applications. This review systemically summarises state-of-the-art implementations of liquid marbles as microreactors. This paper also discusses the various aspects of liquid marble-based microreactors, such as the formation, manipulation, and future perspectives.

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“…Conventional LMs are fabricated by rolling the aqueous drop on the surface of hydrophobic particles, allowing the particles to fully cover the droplets surface, [ 46–48 ] followed by transferring them into organic solvent, known as a “LM‐in‐liquid” concept (Figure 1e). The immersed LMs can be easily extracted from the solution without any changes in morphology or shell destruction, which is importantly useful for further treatment and testing (Figure S1a, Supporting Information).…”

Section: Figurementioning

confidence: 99%

Liquid Marbles in Liquid

Zhao

Chen

Wang

et al. 2020

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Traditional liquid marbles (LMs), liquid droplets encapsulated by hydrophobic particles at the liquid–gas interface, are restricted by their short lifetime and low heat transfer efficiency. Herein, a new paradigm for LMs immersed in various liquid mediums with massive enhanced heat transfer and spatial recognition is designed; without compromising the structural integrity, the lifetime of the liquid marbles in liquid (LMIL) is extended by ≈1000 times compared to classical LMs in air or naked droplets in organic reagents. The LMIL shows promising reverse structural re‐configurability while under external stimuli and maintaining their functionality for a very long period of time (≈weeks). These superior behaviors are further exploited as a miniature reactor with prolonged lifetimes and excellent temperature control, combined with its feasible operation, new opportunities will open up in the advanced chemical and biomedical engineering fields. It is also shown that LMIL can be applied in methylene blue degradation and 3D in‐vitro yeast cell cultures. These findings have important implications for real‐world use of LMs, with a number of applications in cell culture technology, lab‐in‐a‐drop, polymerization, encapsulation, formulation, and drug delivery.

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Liquid Marbles: A Promising and Versatile Platform for Miniaturized Chemical Reactions

Cited by 26 publications

References 18 publications

How Liquid Marbles Break Down: Direct Evidence for Two Breakage Scenarios

How Liquid Marbles Break Down: Direct Evidence for Two Breakage Scenarios

Liquid Marbles as Miniature Reactors for Chemical and Biological Applications

Liquid Marbles in Liquid

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