Liquid membrane phenomena and drug action

Transport across liquid membranes containing vitamin A (retinol acetate)

“…Beyond which they become more or less constant. This trend in L p values is consistent with the liquid membrane hypothesis [6][7][8][9]. Analysis of the values of L p in light of the mosaic model [16][17][18] furnishes further evidence in favor of formation of liquid membrane in series with the supporting membrane.…”

“…Because of the liquid membrane formed by vitamin A on the cytoplasmic membrane of the cell, transport of essential amino acids and cations required for various physiological functions may be altered. In the present model studies, experiments on vitamin A are reported and the data are viewed in the light of the liquid membrane hypothesis of drug action [6]. Data on the hydraulic permeability have been obtained to demonstrate the formation of liquid membranes by vitamin A in series with the supporting membrane.…”

“…The role of surface activity in drug action has been investigated in depth and a liquid membrane hypothesis for the action of such drugs, which act by altering the permeability of the cell membrane, has been proposed [6,7]. The central idea of the hypothesis lies in the assertion that films (which are called liquid membranes) formed by the surface-active drugs at the site of their actions, modifying the transport of relevant permeants to their respective sites, which indeed is passive in nature, also make definite contribution to the drug action [6,7].…”

“…The central idea of the hypothesis lies in the assertion that films (which are called liquid membranes) formed by the surface-active drugs at the site of their actions, modifying the transport of relevant permeants to their respective sites, which indeed is passive in nature, also make definite contribution to the drug action [6,7].…”

Study on Mg2+ removal from ammonium dihydrogen phosphate solution by an emulsion liquid membrane

“…Since Li first applied an ELM to the separation of hydrocarbons [3], ELMs came to be an effective tool for the purification or separation of various materials, involving the transport of precious metal ions [4][5][6], rare earth elements [7], drugs [8][9][10][11][12], phenols [13][14][15], fructose [16][17], and the treatment of seawater [18] and waste water [19][20][21][22].…”