Transport across liquid membranes containing vitamin A (retinol acetate)

Nagappa, Anantha Naik; Kole, Prashant; Pandi, P. V.; Zeeyauddin, K.; Patil, R. T.; Shanmukha, I

doi:10.1016/j.jcis.2003.12.014

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Retinol-acetat je česta forma vitamina A, zastupljena u suplementima u ishrani, multivitaminskih ins-tant napitaka, kao i kod kozmetičkih sredstava za zaštitu kože. Molekuli vitamina A su u stanju da se ugrade u fosfolipidni dvosloj ćelijske membrane, što dovodi do povećanja permeabilnosti ćelijske membrane [19], a da primena koncentracija većih od fizioloških (>70 μM) može izazvati lizu ćelije, naticanje mitohondija kao i hemolizu eritrocita [20].…”

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Inhibitory effect of retinol acetate on horseradish peroxidase

Djuric

Deletic

Stаnkov-Jovаnović

et al. 2013

Hem Ind

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Primary role of peroxidase enzyme is to decompose endogenous hydrogen peroxide, when oxygen radical is being replaced by a less potent radical, which is its cosubstrates oxidized form. During this study, catalytic activity of horseradish peroxidase has been observed in the presence of antioxidants from vitamin group, such as C, E and A, i.e. their water-soluble forms. It was found that vitamin E showed no effect on the enzyme activity and fate of cosubstrate radicals from the group of benzidine derivatives. Vitamin C proceeds enzymatic reaction showing its antioxidative character, and absorbs electrons from radicals, bringing cosubstrate back to its relaxed state. On the other hand, vitamin A plays a role of uncompetitive peroxidase inhibitor, which is visible through decreasing initial rate of catalytic reaction, and is reflected as virtual decrease of enzyme concentration. Furthermore, it prolongs life of endogenous hydrogen peroxide, which could potentially lead to oxidative stress of cells. This inhibitory effect can be used in analytical purpose, for determination of retinol acetate content in a sample

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