Liquid membrane phenomena in chlorpromazine action

Interactions of a phenothiazine tranquilizer with phosphatidylcholine and phosphatidylcholine/cholesterol membranes

“…In the absence of cholesterol, MCP is largely intercalated into the upper region ( hlorpromazine is a major tranquilizer as well as, in a broader sense, a general anesthetic (Seeman, 1972). It has been suggested that the pharmacological mode of action of the phenothiazine type drugs is related to their presence in or at biological membranes (Guth & Spirtes, 1964;Bhise et al, 1983). In particular, the reduction in membrane permeability to dopamine has been cited as the origin of their antipsychotic function (Bhise et al, 1983; Creese et al, 1976).…”

“…It has been suggested that the pharmacological mode of action of the phenothiazine type drugs is related to their presence in or at biological membranes (Guth & Spirtes, 1964;Bhise et al, 1983). In particular, the reduction in membrane permeability to dopamine has been cited as the origin of their antipsychotic function (Bhise et al, 1983; Creese et al, 1976). The specific interactions responsible may be quite complex and involve disordering of the lipid (Pang et al, 1980), disruption of ion channels (Lee, 1976), interaction with membrane protein (LaBella, 1981), or modification of the membrane surface (Bhise et al, 1983;Zografi & Munshi, 1970;Seeman & Bialy, 1963).…”

Liquid Membrane Phenomenon in Diuretics

“…This gradation (Table I) (Table I) lending support to liquid membrane formation. The method of calculation is described in earlier publications (2)(3)(4)(5)(6)(7). Role of Liquid Membrane Formation in Diuretic Action-The primary action of furosemide is to reduce activc absorption of chloride ions (8).…”

Transport across liquid membranes containing vitamin A (retinol acetate)

“…The condition J v = 0 was imposed on the system and the amount of permeant transported to the compartment filled with water in a known period of time was estimated. Details of the method of measurement of solute permeability are the same as described in earlier publications [9][10][11][12]. All measurements were made at constant temperature, using a thermostat setting of 37 ± 0.1 • C.…”

“…The concentration ranges of vitamin A were so chosen that ranges both above and below its CMC value are covered. The procedure adopted for obtaining the hydraulic permeability data has been described in earlier publications [9][10][11][12].…”