Liquisolid Technique: a Novel Tool to Develop Aceclofenac-Loaded Eudragit L-100 and RS-100-Based Sustained Release Tablets

Hussain, Yaseen; Shah, Muhammad Noor

doi:10.1007/s12247-020-09474-w

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…To control the release rate of the osmotic pump, two strategies were employed in this study using a retardant agent in the core of the osmotic pump and the control of porosity on the semipermeable membrane by optimizing the concentration of pore-former in coat solution. To sustain the release rate of sodium carbonate and glucose from the osmotic pump during the first hours of bacterial growth, Eudragit L100, as a retardant agent ( 41 ), was used successfully in the core of the tablet. In addition, the content of the pore-forming agent (PEG 400) in the coating membrane was optimized due to its great effect on the release rate, as this technique was employed in some previous studies to regulate the release rate of metformin hydrochloride ( 42 ) and enalapril ( 43 ) from the osmotic pump.…”

Section: Discussionmentioning

confidence: 99%

Design and Characterization of an Osmotic Pump System for Optimal Feeding and pH Control in E. coli Culture to Increase Biomass

Abedin,

Ranjbari,

Haeri

et al. 2024

Iran J Pharm Res

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Background: Batch cultures used for various purposes, such as expression screening and recombinant protein production in laboratories, usually have some drawbacks due to the bolus addition of carbon sources, such as glucose and buffers, that lead to overflow metabolism, decreased pH, high osmolality, low biomass yield, and low protein production. Objectives: This study aimed to overcome the problems of batch culture using the controlled release concept by a controlled porosity osmotic pump (CPOP) system. Methods: The CPOP was formulated with glucose as a carbon source feeding and sodium carbonate as a pH modifier in the core of the tablet that was coated with a semipermeable membrane containing cellulose acetate and polyethylene glycol (PEG) 400. The release rate was regulated with Eudragit L100 as a retardant agent in the core and PEG 400 as a pore-former agent in the coating membrane. Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to elucidate compatibility between components and release mechanism, respectively. The in-vitro release of glucose and Na2CO3 studies were performed for 24 hours in a mineral culture medium (M9). Then, the effectiveness of CPOP in the growth of Escherichia coli (E. coli) (BL21) (biomass) as a microorganism model was evaluated. Glucose consumption, changes in medium pH, and acetate concentration as a by-product were also monitored during the bacterial growth. Results: Fourier-transform infrared spectroscopy confirmed the compatibility between the components in the osmotic pump, and SEM elucidated the release mechanism due to in-situ delivery pores created by dissolving soluble components (PEG 400) on the coated membrane upon contact with the dissolution medium. The in-vitro release studies indicated that the osmotic pump was able to deliver glucose and sodium carbonate in a zero-order manner. The use of CPOP in E. coli (BL21) cultivation resulted in a statistically significant improvement in biomass (over 80%), maintaining the pH of the medium (above 6.8) during the exponential phase, and reducing metabolic by-product formation (acetate), compared to bolus feeding (P < 0.05). Conclusions: The use of CPOP, which is capable of controlled release of glucose as a carbon source and sodium carbonate as a pH modifier, can overcome the drawbacks of bolus feeding, such as decreased pH, increased acetate concentration, and low productivity. It has a good potential for commercialization.

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Section: Discussionmentioning

confidence: 99%

Design and Characterization of an Osmotic Pump System for Optimal Feeding and pH Control in E. coli Culture to Increase Biomass

Abedin,

Ranjbari,

Haeri

et al. 2024

Iran J Pharm Res

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Design and development of Fujicalin-based axitinib liquisolid compacts for improved dissolution and bioavailability to treat renal cell carcinoma

Yadav,

Hajare,

Patil

2024

European Journal of Pharmaceutics and Biopharmaceutics

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Development of Liquisolid Technology to Overcome Dissolution/Absorption Limitations of Oral Drugs

Wang,

Zhang

2024

Pharmaceutical Fronts

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Increasing influx of poorly water-soluble drugs poses a significant challenge to oral drug delivery. Conventional solubilization techniques such as solid dispersion and cyclodextrin inclusion, while capable of improving drug dissolution, suffer from a great predicament in subsequent formulation processing. A novel “powder solution technology,” the liquisolid technique, has come to the forefront in dealing with drug solubilization and formulation of oral “problem” drugs. The liquisolid technique involves the adsorption of liquid medications onto suitable carrier and coating materials, followed by conversion into free-flowing, dry-looking, and compressible powders. In the liquisolid system, the drug is dispersed in an almost molecular state, which greatly contributes to drug dissolution and absorption. This review aims to present the fundamentals of liquisolid technology and update the concept of liquisolid processing to expand its applications. The trend of modern drug discovery, drug solubilization approaches, application of liquisolid technology in formulation innovation, formulation composition, and design of liquisolid systems were discussed in detail. Special emphasis was placed on the application of liquisolid technology to improve the dissolution and bioavailability of poorly water-soluble drugs. Accumulating evidence shows that the liquisolid technology has immense potential to improve oral delivery and facilitate the secondary development of insoluble drugs.

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Liquisolid Technique: a Novel Tool to Develop Aceclofenac-Loaded Eudragit L-100 and RS-100-Based Sustained Release Tablets

Cited by 4 publications

References 23 publications

Design and Characterization of an Osmotic Pump System for Optimal Feeding and pH Control in E. coli Culture to Increase Biomass

Design and Characterization of an Osmotic Pump System for Optimal Feeding and pH Control in E. coli Culture to Increase Biomass

Design and development of Fujicalin-based axitinib liquisolid compacts for improved dissolution and bioavailability to treat renal cell carcinoma

Development of Liquisolid Technology to Overcome Dissolution/Absorption Limitations of Oral Drugs

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